All Outputs (2)

A dynamical model of TGF-β activation in asthmatic airways (2023)
Journal Article
Pybus, H. J., O’dea, R. D., & Brook, B. S. (2023). A dynamical model of TGF-β activation in asthmatic airways. Mathematical Medicine and Biology, 40(3), 238-265. https://doi.org/10.1093/imammb/dqad004

Excessive activation of the regulatory cytokine transforming growth factor β (TGF-β) via contraction of airway smooth muscle (ASM) is associated with the development of asthma. In this study, we develop an ordinary differential equation model that de... Read More about A dynamical model of TGF-β activation in asthmatic airways.

Differential remodelling in small and large murine airways revealed by novel whole lung airway analysis (2023)
Journal Article
Tatler, A. L., Philp, C. J., Hill, M. R., Cox, S., Bullock, A. M., John, A., …Brook, B. S. (2023). Differential remodelling in small and large murine airways revealed by novel whole lung airway analysis. American Journal of Physiology-Lung Cellular and Molecular Physiology, 324(3), L271-L284. https://doi.org/10.1152/ajplung.00034.2022

Airway remodelling occurs in chronic asthma leading to increased airway smooth muscle (ASM) mass and extra-cellular matrix (ECM) deposition. Whilst extensively studied in murine airways, studies report only selected larger airways at one time point m... Read More about Differential remodelling in small and large murine airways revealed by novel whole lung airway analysis.