All Outputs (3)

Effect of Excipients on Salt Disproportionation during Dissolution: A Novel Application of In Situ Raman Imaging (2021)
Journal Article
Abouselo, A., Rance, G. A., Tres, F., Taylor, L. S., Kwokal, A., Renou, L., …Aylott, J. W. (2021). Effect of Excipients on Salt Disproportionation during Dissolution: A Novel Application of In Situ Raman Imaging. Molecular Pharmaceutics, 18(9), 3247-3259. https://doi.org/10.1021/acs.molpharmaceut.1c00119

We have employed a bespoke setup combining confocal Raman microscopy and an ultraviolet–visible (UV–Vis) spectroscopy flow cell to investigate the effect of excipients on the disproportionation kinetics of Pioglitazone HCl (PioHCl) in tablets during... Read More about Effect of Excipients on Salt Disproportionation during Dissolution: A Novel Application of In Situ Raman Imaging.

Fluorescent nanosensors reveal dynamic pH gradients during biofilm formation (2021)
Journal Article
Hollmann, B., Perkins, M., Chauhan, V. M., Aylott, J. W., & Hardie, K. R. (2021). Fluorescent nanosensors reveal dynamic pH gradients during biofilm formation. npj Biofilms and Microbiomes, 7(1), Article 50. https://doi.org/10.1038/s41522-021-00221-8

Understanding the dynamic environmental microniches of biofilms will permit us to detect, manage and exploit these communities. The components and architecture of biofilms have been interrogated in depth; however, little is known about the environmen... Read More about Fluorescent nanosensors reveal dynamic pH gradients during biofilm formation.

Immunity in space: prokaryote adaptations and immune response in microgravity (2021)
Journal Article
Green, M. J., Aylott, J. W., Williams, P., Ghaemmaghami, A. M., & Williams, P. M. (2021). Immunity in space: prokaryote adaptations and immune response in microgravity. Life, 11(2), Article 112. https://doi.org/10.3390/life11020112

Immune dysfunction has long been reported by medical professionals regarding astronauts suffering from opportunistic infections both during their time in space and a short period afterwards once back on Earth. Various species of prokaryotes onboard t... Read More about Immunity in space: prokaryote adaptations and immune response in microgravity.