All Outputs (3)

Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors (2020)
Journal Article
Zhu, H., Sun, H., Liu, Y., Duan, Y., Liu, J., Yang, X., …Xu, J. (2020). Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors. European Journal of Medicinal Chemistry, 207, Article 112716. https://doi.org/10.1016/j.ejmech.2020.112716

A series of novel vinyl selenone derivatives were designed, synthesized and evaluated as the tubulin polymerization inhibitors using a bioisosteric strategy. Among them, the representative compound 11k exhibited satisfactory anti-proliferative activi... Read More about Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors.

Corrigendum to “Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors” [Eur. J. Med. Chem. 197 (2020) 112308] (European Journal of Medicinal Chemistry (2020) 197, (S0223523420302774), (10.1016/j.ejmech.2020.112308)) (2020)
Journal Article
Shuai, W., Li, X., Li, W., Xu, F., Lu, L., Yao, H., …Xu, J. (2020). Corrigendum to “Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors” [Eur. J. Med. Chem. 197 (2020) 112308] (European Journal of Medicinal Chemistry (2020) 197, (S0223523420302774), (10.1016/j.ejmech.2020.112308)). European Journal of Medicinal Chemistry, 200, Article 112464. https://doi.org/10.1016/j.ejmech.2020.112464

Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors (2020)
Journal Article
Shuai, W., Li, X., Li, W., Xu, F., Lu, L., Yao, H., …Xu, J. (2020). Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. European Journal of Medicinal Chemistry, 197, Article 112308. https://doi.org/10.1016/j.ejmech.2020.112308

A series of novel isocombretapyridines were designed and synthesized based on a lead compound isocombretastatin A-4 (isoCA-4) by replacing 3,4,5-trimethoxylphenyl with substituent pyridine nucleus. The MTT assay results showed that compound 20a posse... Read More about Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors.