All Outputs (2)

Calbindin Deficits May Underlie Dissociable Effects of 5-HT6 and mGlu7 Antagonists on Glutamate and Cognition in a Dual-Hit Neurodevelopmental Model for Schizophrenia (2020)
Journal Article
Shortall, S. E., Brown, A. M., Newton-Mann, E., Dawe-Lane, E., Evans, C., Fowler, M., & King, M. V. (2020). Calbindin Deficits May Underlie Dissociable Effects of 5-HT6 and mGlu7 Antagonists on Glutamate and Cognition in a Dual-Hit Neurodevelopmental Model for Schizophrenia. Molecular Neurobiology, 57(9), 3439–3457. https://doi.org/10.1007/s12035-020-01938-x

© 2020, The Author(s). Despite several compounds entering clinical trials for the negative and cognitive symptoms of schizophrenia, few have progressed beyond phase III. This is partly attributed to a need for improved preclinical models, to understa... Read More about Calbindin Deficits May Underlie Dissociable Effects of 5-HT6 and mGlu7 Antagonists on Glutamate and Cognition in a Dual-Hit Neurodevelopmental Model for Schizophrenia.

A method for reducing animal use whilst maintaining statistical power in electrophysiological recordings from rodent nerves (2020)
Journal Article
Rich, L. R., Patrick, J. A., Hamner, M. A., Ransom, B. R., & Brown, A. M. (2020). A method for reducing animal use whilst maintaining statistical power in electrophysiological recordings from rodent nerves. Heliyon, 6(6), https://doi.org/10.1016/j.heliyon.2020.e04143

The stimulus evoked compound action potential, recorded from ex vivo nerve trunks such as the rodent optic and sciatic nerve, is a popular model system used to study aspects of nervous system metabolism. This includes (1) the role of glycogen in supp... Read More about A method for reducing animal use whilst maintaining statistical power in electrophysiological recordings from rodent nerves.