All Outputs (4)

Paternal low protein diet and the supplementation of methyl-donors impact fetal growth and placental development in mice (2020)
Journal Article
Morgan, H. L., Aljumah, A., Rouillon, C., & Watkins, A. J. (2021). Paternal low protein diet and the supplementation of methyl-donors impact fetal growth and placental development in mice. Placenta, 103, 124-133. https://doi.org/10.1016/j.placenta.2020.10.020

Introduction Paternal low-protein diet can alter sperm methylation status, fetal growth and program offspring ill-health, however its impact on the placenta remains poorly defined. Here we examine the influence paternal low-protein diet has on fetal... Read More about Paternal low protein diet and the supplementation of methyl-donors impact fetal growth and placental development in mice.

The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring (2020)
Journal Article
Aljahdali, A., Airina, R. K. R. I., Velazquez, M. A., Sheth, B., Wallen, K., Osmond, C., …Fleming, T. P. (2020). The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring. Human Reproduction, 35(11), 2497–2514. https://doi.org/10.1093/humrep/deaa205

Study question: Do the long-term health outcomes following IVF differ depending upon the duration of embryo culture before transfer? Summary answer: Using a mouse model, we demonstrate that in male but not female offspring, adverse cardiovascular... Read More about The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring.

Extraction of Lipids from Liquid Biological Samples for High-Throughput Lipidomics (2020)
Journal Article
Furse, S., Watkins, A. J., & Koulman, A. (2020). Extraction of Lipids from Liquid Biological Samples for High-Throughput Lipidomics. Molecules, 25(14), https://doi.org/10.3390/molecules25143192

Extraction of the lipid fraction is a key part of acquiring lipidomics data. High-throughput lipidomics, the extraction of samples in 96w plates that are then run on 96 or 384w plates, has particular requirements that mean special development work is... Read More about Extraction of Lipids from Liquid Biological Samples for High-Throughput Lipidomics.

Low protein diet and methyl-donor supplements modify testicular physiology in mice (2020)
Journal Article
Morgan, H. L., Ampong, I., Eid, N., Rouillon, C., Griffiths, H. R., & Watkins, A. J. (2020). Low protein diet and methyl-donor supplements modify testicular physiology in mice. Reproduction, 159(5), 627-641. https://doi.org/10.1530/rep-19-0435

The link between male diet and sperm quality has received significant investigation. However, the impact diet and dietary supplements have on the testicular environment has been examined to a lesser extent. Here, we establish the impact of a sub-opti... Read More about Low protein diet and methyl-donor supplements modify testicular physiology in mice.