All Outputs (2)

Theory and simulations for RNA folding in mixtures of monovalent and divalent cations (2019)
Journal Article
Nguyen, H. T., Hori, N., & Thirumalai, D. (2019). Theory and simulations for RNA folding in mixtures of monovalent and divalent cations. Proceedings of the National Academy of Sciences, 116(42), 21022-21030. https://doi.org/10.1073/pnas.1911632116

RNA molecules require ions to fold. The problem of how ions of differing sizes and valences drive the folding of RNA molecules is unsolved. Here, we take a major step in its solution by creating a method, based on the theory of polyatomic liquids, to... Read More about Theory and simulations for RNA folding in mixtures of monovalent and divalent cations.

Ion Condensation onto Ribozyme Is Site Specific and Fold Dependent (2019)
Journal Article
Hori, N., Denesyuk, N. A., & Thirumalai, D. (2019). Ion Condensation onto Ribozyme Is Site Specific and Fold Dependent. Biophysical Journal, 116(12), 2400-2410. https://doi.org/10.1016/j.bpj.2019.04.037

The highly charged RNA molecules, with each phosphate carrying a single negative charge, cannot fold into well-defined architectures with tertiary interactions in the absence of ions. For ribozymes, divalent cations are known to be more efficient tha... Read More about Ion Condensation onto Ribozyme Is Site Specific and Fold Dependent.