All Outputs (4)

End-stapled homo and hetero collagen triple helices: A click chemistry approach (2010)
Journal Article
Byrne, C., McEwan, P. A., Emsley, J., Fischer, P. M., & Chan, W. C. (2011). End-stapled homo and hetero collagen triple helices: A click chemistry approach. Chemical Communications, 47(9), 2589-2591. https://doi.org/10.1039/c0cc04795c

A CuAAC reaction was established for modular synthesis of end-stapled homo- and hetero-triple helical peptides, generating "clicked" macro-assemblies with enhanced thermal stability. © 2011 The Royal Society of Chemistry.

Protease sensing with nanoparticle based platforms (2010)
Journal Article
Welser, K., Adsley, R., Moore, B. M., Chan, W. C., & Aylott, J. W. (2011). Protease sensing with nanoparticle based platforms. Analyst, 136(1), 29-41. https://doi.org/10.1039/c0an00429d

Nanoparticulate systems in various unique configurations are highly effective at detecting protease activity both in vivo and in vitro. In this article, we have summarised the conventional modern methods for monitoring protease activity, and critical... Read More about Protease sensing with nanoparticle based platforms.

Regulation of neurotoxin production and sporulation by a putative agrBD signaling system in proteolytic Clostridium botulinum (2010)
Journal Article
Cooksley, C. M., Davis, I. J., Winzer, K., Chan, W. C., Peck, M. W., & Minton, N. P. (2010). Regulation of neurotoxin production and sporulation by a putative agrBD signaling system in proteolytic Clostridium botulinum. Applied and Environmental Microbiology, 76(13), 4448-4460. https://doi.org/10.1128/AEM.03038-09

A significant number of genome sequences of Clostridium botulinum and related species have now been determined. In silico analysis of these data revealed the presence of two distinct agr loci (agr-1 and agr-2) in all group I strains, each encoding pu... Read More about Regulation of neurotoxin production and sporulation by a putative agrBD signaling system in proteolytic Clostridium botulinum.

5-Carboxyfluorescein tagged N-phenylanthranilamide as a tracer reagent for fluorescence polarization: A robust method to screen MAPK pathway allosteric inhibitors (2010)
Journal Article
Rezvani, Z. N., Mayer, R. J., & Chan, W. C. (2010). 5-Carboxyfluorescein tagged N-phenylanthranilamide as a tracer reagent for fluorescence polarization: A robust method to screen MAPK pathway allosteric inhibitors. Chemical Communications, 46(12), 2043-2045. https://doi.org/10.1039/b925042e

Fluorescence polarization using Nα-(fluorescein-5- carbonyl)-Nε-(N-[2-fluoro-4-iodophenyl]-3,4- difluoroanthraniloyl)lysyl amide is capable of rapidly identifying inhibitor ligands that bind to an allosteric site in MEK1. © The Royal Society of Chemi... Read More about 5-Carboxyfluorescein tagged N-phenylanthranilamide as a tracer reagent for fluorescence polarization: A robust method to screen MAPK pathway allosteric inhibitors.