The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex

Koo, Chek Ziu; Harrison, Neale; Noy, Peter J.; Szyroka, Justyna; Matthews, Alexandra L.; Hsia, Hung En; M�ller, Stephan A.; T�shaus, Johanna; Goulding, Joelle; Willis, Katie; Apicella, Clara; Cragoe, Bethany; Davis, Edward; Keles, Murat; Malinova, Antonia; McFarlane, Thomas A.; Morrison, Philip R.; Nguyen, Hanh T.H.; Sykes, Michael C.; Ahmed, Haroon; Di Maio, Alessandro; Seipold, Lisa; Saftig, Paul; Cull, Eleanor; Pliotas, Christos; Rubinstein, Eric; Poulter, Natalie S.; Briddon, Stephen J.; Holliday, Nicholas D.; Lichtenthaler, Stefan F.; Tomlinson, Michael G.

doi:10.1074/jbc.RA120.012601

All Outputs (2)

CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of ?2AR in isogenic hPSC-derived cardiomyocytes (2020)
Journal Article
Kondrashov, A., Mohd Yusof, N. A., Hasan, A., Goulding, J., Kodagoda, T., Hoang, D. M., …Denning, C. (2021). CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β2AR in isogenic hPSC-derived cardiomyocytes. Molecular Therapy - Methods and Clinical Development, 20, 39-53. https://doi.org/10.1016/j.omtm.2020.10.019

© 2020 During normal- and patho-physiological situations, the behavior of the beta2-adrenoreceptor (β2AR) is influenced by polymorphic variants. The functional impact of such polymorphisms has been suggested from data derived from genetic association... Read More about CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of ?2AR in isogenic hPSC-derived cardiomyocytes.

The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex (2020)
Journal Article
Koo, C. Z., Harrison, N., Noy, P. J., Szyroka, J., Matthews, A. L., Hsia, H. E., …Tomlinson, M. G. (2020). The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex. Journal of Biological Chemistry, 295(36), 12822-12839. https://doi.org/10.1074/jbc.RA120.012601

© 2020 Koo et al. A disintegrin and metalloprotease 10 (ADAM10) is a transmembrane protein essential for embryonic development, and its dysregulation underlies disorders such as cancer, Alzheimer's disease, and inflammation. ADAM10 is a "molecular sc... Read More about The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.