Unravelling intrinsic efficacy and ligand bias at G protein coupled receptors: A practical guide to assessing functional data
(2015)
Journal Article
Stott, L. A., Hall, D. A., & Holliday, N. D. (2016). Unravelling intrinsic efficacy and ligand bias at G protein coupled receptors: A practical guide to assessing functional data. Biochemical Pharmacology, 101, 1-12. https://doi.org/10.1016/j.bcp.2015.10.011
© 2015 Elsevier Inc. All rights reserved. Stephenson's empirical definition of an agonist, as a ligand with binding affinity and intrinsic efficacy (the ability to activate the receptor once bound), underpins classical receptor pharmacology. Quantify... Read More about Unravelling intrinsic efficacy and ligand bias at G protein coupled receptors: A practical guide to assessing functional data.