All Outputs (4)

LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes (2015)
Journal Article
Kim, D., Achcar, F., Breitling, R., Burgess, K., & Barrett, M. (2015). LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes. Metabolomics, 11(6), 1721-1732. https://doi.org/10.1007/s11306-015-0827-2

Human African trypanosomiasis is a neglected tropical disease caused by the protozoan parasite, Trypanosoma brucei. In the mammalian bloodstream, the trypanosome’s metabolism differs significantly from that of its host. For example, the parasite reli... Read More about LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes.

Potent trypanocidal curcumin analogs bearing a mono-enone linker Motif act on Trypanosoma brucei by forming an adduct with trypanothione (2015)
Journal Article
Alkhaldi, A. A. M., Creek, D. J., Ibrahim, H., Kim, D., Quashie, N. B., Burgess, K. E., …de Koning, H. P. (2015). Potent trypanocidal curcumin analogs bearing a mono-enone linker Motif act on Trypanosoma brucei by forming an adduct with trypanothione. Molecular Pharmacology, 87(3), 451-464. https://doi.org/10.1124/mol.114.096016

We have previously reported that curcumin analogs with a C7 linker bearing a C4-C5 olefinic linker with a single keto group at C3 (enone linker) display midnanomolar activity against the bloodstream form of Trypanosoma brucei. However, no clear indic... Read More about Potent trypanocidal curcumin analogs bearing a mono-enone linker Motif act on Trypanosoma brucei by forming an adduct with trypanothione.

Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose (2015)
Journal Article
Creek, D. J., KIM, D., Mazet, M., Achcar, F., Anderson, J., Kamour, R., …Barrett, M. P. (2015). Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose. PLoS Pathogens, 11(3), https://doi.org/10.1371/journal.ppat.1004689

Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe the metabolic pathways active in cultured bloodstream form trypomastigotes of Trypanosoma brucei, a parasite responsible for human African trypanosomiasis. Glucose e... Read More about Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose.

Investigating gender differences in the factor structure of the Gudjonsson Compliance Scale (2015)
Journal Article
Drake, K. E., & Egan, V. (2017). Investigating gender differences in the factor structure of the Gudjonsson Compliance Scale. Legal and Criminological Psychology, 22(1), https://doi.org/10.1111/lcrp.12081

Purpose: The Gudjonsson Compliance Scale (GCS) remains, in terms of its psychometrics, an under-researched instrument, in which gender differences in particular have been insufficiently examined. The aim of this research was to therefore investigate... Read More about Investigating gender differences in the factor structure of the Gudjonsson Compliance Scale.