Effects of α-synuclein overexpression in transgenic Caenorhabditis elegans strains
(2012)
Journal Article
Bodhicharla, R., Nagarajan, A., Winter, J., Adenle, A., Nazir, A., Brady, D., Vere, K., Richens, J., O'Shea, P., Bell, D. R., & de Pomerai, D. I. (2012). Effects of α-synuclein overexpression in transgenic Caenorhabditis elegans strains. CNS and Neurological Disorders - Drug Targets, 11(8), https://doi.org/10.2174/1871527311211080005
The neural protein α-synuclein aggregates both in vivo and in vitro to form insoluble fibrils that are involved in
Parkinson’s disease pathogenesis. We have generated α-synuclein/fluorescent-protein fusion constructs overexpressed in muscle cells of...
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