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Can GPs working in secure environments in England re-license using the Royal College of General Practitioners revalidation proposals? (2012)
Journal Article
Coomber, J., Charlton, R., Thistlethwaite, J. E., & England, L. (2012). Can GPs working in secure environments in England re-license using the Royal College of General Practitioners revalidation proposals?. BMC Family Practice, 13(123), https://doi.org/10.1186/1471-2296-13-123

Background
Revalidation for UK doctors is expected to be introduced from late 2012. For general practitioners (GPs), this entails collecting supporting information to be submitted and assessed in a revalidation portfolio every five years. The aim of... Read More about Can GPs working in secure environments in England re-license using the Royal College of General Practitioners revalidation proposals?.

Medieval business networks: St Mary's guild and the borough court in later medieval Nottingham (2012)
Journal Article
Goddard, R. (2013). Medieval business networks: St Mary's guild and the borough court in later medieval Nottingham. Urban History, 40(1), 3-27. https://doi.org/10.1017/s0963926812000600

Historians have suggested that medieval urban guilds played a role in political and commercial networking. Guilds' commercial protectionism was designed to benefit their membership and close ties have been discovered between merchant guilds and urban... Read More about Medieval business networks: St Mary's guild and the borough court in later medieval Nottingham.

Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition (2012)
Journal Article
Smith, S. J., Wilson, M., Ward, J. H., Rahman, C. V., Peet, A. C., Macarthur, D. C., Rose, F. R., Grundy, R. G., & Rahman, R. (2012). Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition. PLoS ONE, 7(12), Article e52335. https://doi.org/10.1371/journal.pone.0052335

INTRODUCTION

Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated... Read More about Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.

Profiling strugglers in a graduate-entry medicine course at Nottingham: a retrospective case study (2012)
Journal Article
Garrud, P., & Yates, J. (2012). Profiling strugglers in a graduate-entry medicine course at Nottingham: a retrospective case study. BMC Medical Education, 12(Decemb), Article 8. https://doi.org/10.1186/1472-6920-12-124

Background

10-15% of students struggle at some point in their medicine course. Risk factors include weaker academic qualifications, male gender, mental illness, UK ethnic minority status, and poor study skills. Recent research on an undergraduate... Read More about Profiling strugglers in a graduate-entry medicine course at Nottingham: a retrospective case study.

The cosmology of the Fab-Four (2012)
Journal Article
Copeland, E. J., Padilla, A., & Saffin, P. M. (2012). The cosmology of the Fab-Four. Journal of Cosmology and Astroparticle Physics, 2012(12), Article 026. https://doi.org/10.1088/1475-7516/2012/12/026

We have recently proposed a novel self tuning mechanism to alleviate the famous cosmological constant problem, based on the general scalar tensor theory proposed by Horndeski. The self-tuning model ends up consisting of four geometric terms in the ac... Read More about The cosmology of the Fab-Four.

Click chemistry in carbon nanoreactors (2012)
Journal Article
Rance, G. A., Solomonsz, W. A., & Khobystov, A. N. (2013). Click chemistry in carbon nanoreactors. Chemical Communications, 49(11), https://doi.org/10.1039/C2CC38035H

Copper-nanoparticle catalytic centres anchored at the 5 graphitic step-edges within hollow carbon nanoreactors exhibit superior activity and stability in cycloaddition reactions as compared to catalytic centres outside the nanoreactors. Nanoscale con... Read More about Click chemistry in carbon nanoreactors.

Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator (2012)
Journal Article
Mobasheri, A. (2012). Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator. Frontiers in Endocrinology, 3(153), Article 153. https://doi.org/10.3389/fendo.2012.00153

In the skeletal system glucose serves as an essential source of energy for the development, growth, and maintenance of bone and articular cartilage. It is particularly needed for skeletal morphogenesis during embryonic growth and fetal development. G... Read More about Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator.

An innovative psychometric solar-powered water desalination system (2012)
Journal Article
Shatat, M., Riffat, S., & Gan, G. (2016). An innovative psychometric solar-powered water desalination system. International Journal of Low-Carbon Technologies, 11(2), https://doi.org/10.1093/ijlct/cts075

Important advances have been made in solar water desalination technology but their wide application is restricted by relatively high capital and running costs. Until recently, solar concentrator collectors had usually been employed to distill water i... Read More about An innovative psychometric solar-powered water desalination system.

A comparative study of adhesion of melanoma and breast cancer cells to blood and lymphatic endothelium (2012)
Journal Article
Safuan, S., Storr, S. J., Patel, P. M., & Martin, S. G. (2012). A comparative study of adhesion of melanoma and breast cancer cells to blood and lymphatic endothelium. Lymphatic Research and Biology, 10(4), https://doi.org/10.1089/lrb.2012.0007

Background: Lymphovascular invasion (LVI) is an important step in the metastatic cascade; tumor cell migration
and adhesion to blood and lymphatic vessels is followed by invasion through the vessel wall and subsequent
systemic spread. Although prim... Read More about A comparative study of adhesion of melanoma and breast cancer cells to blood and lymphatic endothelium.

Identification of a nonselective cation channel in isolated lens fiber cells that is activated by cell shrinkage (2012)
Journal Article
Gunning, S. J., Chung, K. K., Donaldson, P. J., & Webb, K. F. (2012). Identification of a nonselective cation channel in isolated lens fiber cells that is activated by cell shrinkage. American Journal of Physiology - Cell Physiology, 303(12), C1252-C1259. https://doi.org/10.1152/ajpcell.00237.2012

The initiation of lens cataract has long been associated with the development of a membrane "leak" in lens fiber cells that depolarizes the lens intracellular potential and elevates intracellular Na+ and Ca2+ concentrations. It has been proposed that... Read More about Identification of a nonselective cation channel in isolated lens fiber cells that is activated by cell shrinkage.

The “Sharp” blade against HIF-mediated metastasis (2012)
Journal Article
Amelio, I., & Melino, G. (2012). The “Sharp” blade against HIF-mediated metastasis. Cell Cycle, 11(24), 4530-4535. https://doi.org/10.4161/cc.22820

Hypoxia-inducible factors (HIFs) control cellular adaptation to oxygen deprivation. Cancer cells engage HIFs to sustain their growth in adverse conditions, thus promoting a cellular reprograming that includes metabolism, proliferation, survival and m... Read More about The “Sharp” blade against HIF-mediated metastasis.

The placental renin-angiotensin system and oxidative stress in pre-eclampsia (2012)
Journal Article
Mistry, H., Kurlak, L., & Broughton Pipkin, F. (2013). The placental renin-angiotensin system and oxidative stress in pre-eclampsia. Placenta, 34(2), https://doi.org/10.1016/j.placenta.2012.11.027

There is an inverse correlation between human birthweight and umbilical venous angiotensin II (AngII) concentrations. Oxidative stress and increased pro-renin receptor (PRR) both enhance the cleavage of angiotensin I from angiotensinogen (AGT). Pre-e... Read More about The placental renin-angiotensin system and oxidative stress in pre-eclampsia.

Enhancing thermal properties of asphalt materials for heat storage and transfer applications (2012)
Journal Article
Dawson, A. R., Dehdezi, P. K., Hall, M. R., Wang, J., & Isola, R. (in press). Enhancing thermal properties of asphalt materials for heat storage and transfer applications. Road Materials and Pavement Design, 13(4), https://doi.org/10.1080/14680629.2012.735791

The paper considers extending the role of asphalt concrete pavements to become solar heat collectors and storage systems. The majority of the construction cost is already procured for such pavements and only marginal additional costs are likely to be... Read More about Enhancing thermal properties of asphalt materials for heat storage and transfer applications.

The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimurium (2012)
Journal Article
Huett, A., Heath, R. J., Begun, J., Sassi, S. O., Baxt, L. A., Vyas, J. M., Goldberg, M. B., & Xavier, R. J. (2012). The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimurium. Cell Host and Microbe, 12(6), 778-790. https://doi.org/10.1016/j.chom.2012.10.019

Several species of pathogenic bacteria replicate within an intracellular vacuolar niche. Bacteria that escape into the cytosol are captured by the autophagic pathway and targeted for lysosomal degradation, representing a defense against bacterial exp... Read More about The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimurium.

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons (2012)
Journal Article
St Gelais, C., de Silva, S., Amie, S. M., Coleman, C. M., Hoy, H., Hollenbaugh, J. A., Kim, B., & Wu, L. (2012). SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons. Retrovirology, 9(1), Article 105. https://doi.org/10.1186/1742-4690-9-105

Induction of labour versus expectant management for nulliparous women over 35 years of age: a multi-centre prospective, randomised controlled trial (2012)
Journal Article
Walker, K. F., Bugg, G., Macpherson, M., McCormick, C., Wildsmith, C., Smith, G., & Thornton, J. (2012). Induction of labour versus expectant management for nulliparous women over 35 years of age: a multi-centre prospective, randomised controlled trial. BMC Pregnancy and Childbirth, 12(Decemb), Article 8. https://doi.org/10.1186/1471-2393-12-145

Background: British women are increasingly delaying childbirth. The proportion giving birth over the age of 35 rose from 12% in 1996 to 20% in 2006. Women over this age are at a higher risk of perinatal death, and antepartum stillbirth accounts for 6... Read More about Induction of labour versus expectant management for nulliparous women over 35 years of age: a multi-centre prospective, randomised controlled trial.

Examining the role of oral contraceptive users as an experimental and/or control group in athletic performance studies (2012)
Journal Article
Elliott-Sale, K. J., Smith, S., Bacon, J., Clayton, D., McPhilimey, M., Goutianos, G., Hampson, J., & Sale, C. (2013). Examining the role of oral contraceptive users as an experimental and/or control group in athletic performance studies. Contraception, 88(3), 408-412. https://doi.org/10.1016/j.contraception.2012.11.023

Background

This study was conducted to examine the effect of oral contraceptives on endogenous reproductive hormone levels in order to assess the suitability of oral contraceptive users as experimental and/or control groups in human performance st... Read More about Examining the role of oral contraceptive users as an experimental and/or control group in athletic performance studies.

Second hand smoke exposure and the risk of invasive meningococcal disease in children: systematic review and meta-analysis (2012)
Journal Article
Murray, R. L., Britton, J., & Leonardi-Bee, J. (2012). Second hand smoke exposure and the risk of invasive meningococcal disease in children: systematic review and meta-analysis. BMC Public Health, 12(Decemb), Article 11. https://doi.org/10.1186/1471-2458-12-1062

Background

Invasive meningococcal disease remains an important cause of serious morbidity and mortality in children and young people. There is a growing body of literature to suggest that exposure to passive smoke may play a role in the developmen... Read More about Second hand smoke exposure and the risk of invasive meningococcal disease in children: systematic review and meta-analysis.