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All Outputs (125)

Ant colony optimisation for community pharmacy dispensing process based on infield observations (2019)
Presentation / Conference Contribution
Naybour, M., Remenyte-Prescott, R., & Boyd, M. (2019, September). Ant colony optimisation for community pharmacy dispensing process based on infield observations. Presented at ESREL 2019, Hannover, Germany

he community pharmacy dispensing process is an integral part of delivering effective primary care to patients around the world. However, dispensing error rates and related patient safety issues are always a concern in the sector, where studies have f... Read More about Ant colony optimisation for community pharmacy dispensing process based on infield observations.

Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor (2019)
Journal Article
Comeo, E., Kindon, N. D., Soave, M., Stoddart, L. A., Kilpatrick, L. E., Scammells, P. J., Hill, S. J., & Kellam, B. (2020). Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor. Journal of Medicinal Chemistry, 63(5), 2656-2672. https://doi.org/10.1021/acs.jmedchem.9b01856

© 2019 American Chemical Society. Among class A G protein-coupled receptors (GPCR), the human adenosine A2A receptor (hA2AAR) remains an attractive drug target. However, translation of A2AAR ligands into the clinic has proved challenging and an impro... Read More about Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor.

Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide (2019)
Journal Article
Sodano, F., Cavanagh, R., Pearce, A. K., Lazzarato, L., Rolando, B., Fraix, A., Fedatto Abelha, T., Vasey, C., Alexander, C., Taresco, V., & Sortino, S. (2020). Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide. Biomaterials Science, 8(5), 1329-1344. https://doi.org/10.1039/c9bm01644a

© 2020 The Royal Society of Chemistry. Combinations of conventional chemotherapeutics with unconventional anticancer agents such as reactive oxygen and nitrogen species may offer treatment benefits for cancer therapies. Here we report a novel polymer... Read More about Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide.

Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy (2019)
Journal Article
Luveta, J., Parks, R. M., Heery, D. M., Cheung, K.-L., & Johnston, S. J. (2020). Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy. Oncology and Therapy, 8, 1-11. https://doi.org/10.1007/s40487-019-00105-0

Invasive lobular carcinoma comprises 10–15% of all breast cancers and is increasingly recognised as a distinct and understudied disease compared with the predominant histological subtype, invasive ductal carcinoma. Hallmarks of invasive lobular carci... Read More about Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy.

Updating and validating quality prescribing indicators for use in Australian general practice (2019)
Journal Article
Phuong Linh Dang, C., Shean Toh, L., Cooling, N., Jackson, S., Curtain, C., Thompson, A., & Peterson, G. (2020). Updating and validating quality prescribing indicators for use in Australian general practice. Australian Journal of Primary Health, 26(1), 31-42. https://doi.org/10.1071/PY19060

© 2019 La Trobe University. This study aims to update and validate quality prescribing indicators (QPIs) for Australian general practice. The study comprised two phases: (1) developing preliminary potential QPIs based on the 2006 National Prescribing... Read More about Updating and validating quality prescribing indicators for use in Australian general practice.

Multi-material 3D bioprinting of porous constructs for cartilage regeneration (2019)
Journal Article
Ruiz-Cantu, L., Gleadall, A., Faris, C., Segal, J., Shakesheff, K., & Yang, J. (2020). Multi-material 3D bioprinting of porous constructs for cartilage regeneration. Materials Science and Engineering: C, 109, Article 110578. https://doi.org/10.1016/j.msec.2019.110578

© 2020 Elsevier B.V. The current gold standard for nasal reconstruction after rhinectomy or severe trauma includes transposition of autologous cartilage grafts in conjunction with coverage using an autologous skin flap. Harvesting autologous cartilag... Read More about Multi-material 3D bioprinting of porous constructs for cartilage regeneration.

Ligand-induced conformational selection predicts the selectivity of cysteine protease inhibitors (2019)
Journal Article
Sartori, G. R., Leitão, A., Montanari, C. A., & Laughton, C. A. (2019). Ligand-induced conformational selection predicts the selectivity of cysteine protease inhibitors. PLoS ONE, 14(12), Article e0222055. https://doi.org/10.1371/journal.pone.0222055

Cruzain, a cysteine protease of Trypanosoma cruzi, is a validated target for the treatment of Chagas disease. Due to its high similarity in three-dimensional structure with human cathepsins and their sequence identity above 70% in the active site reg... Read More about Ligand-induced conformational selection predicts the selectivity of cysteine protease inhibitors.

A simple and efficient method for polymer coating of iron oxide nanoparticles (2019)
Journal Article
Abushrida, A., Elhuni, I., Taresco, V., Marciani, L., Stolnik, S., & Garnett, M. C. (2020). A simple and efficient method for polymer coating of iron oxide nanoparticles. Journal of Drug Delivery Science and Technology, 55, Article 101460. https://doi.org/10.1016/j.jddst.2019.101460

Iron oxide nanoparticles (IONP) have many possible uses including as MRI contrast agents, for drug delivery and cell labelling, but need to be stabilised and to be rendered biocompatible through appropriate coatings. Many current coatings are subopti... Read More about A simple and efficient method for polymer coating of iron oxide nanoparticles.

Implementing FIP's global pharmaceutical education transformation vision in Sub-Saharan African countries (2019)
Journal Article
Uzman, N., Williams, A. E., Altiere, R. J., Anderson, C., & Bates, I. (2020). Implementing FIP's global pharmaceutical education transformation vision in Sub-Saharan African countries. Research in Social and Administrative Pharmacy, 16(8), 1131-1135. https://doi.org/10.1016/j.sapharm.2019.12.011

The realization of a competent, versatile and adaptable Pharmaceutical workforce which is a key component in achieving the World Health Organization Universal Health Coverage agenda in 2030 depends on the supply of adequately trained pharmacy workfor... Read More about Implementing FIP's global pharmaceutical education transformation vision in Sub-Saharan African countries.

Development of bioactive electrospun scaffolds suitable to support skin fibroblasts and release Lucilia sericata maggot excretion/secretion (2019)
Preprint / Working Paper
Giacaman, A. G., Styliari, I. D., Taresco, V., Pritchard, D., Alexander, C., & Rose, F. R. Development of bioactive electrospun scaffolds suitable to support skin fibroblasts and release Lucilia sericata maggot excretion/secretion

Larval therapy has been reported to exert beneficial actions upon chronic wound healing by promoting granulation tissue formation, antimicrobial activity and degrading necrotic tissue. However, the use of live maggots is problematic for patient accep... Read More about Development of bioactive electrospun scaffolds suitable to support skin fibroblasts and release Lucilia sericata maggot excretion/secretion.

Meeting report: 27th Annual GP2A Medicinal Chemistry Conference (2019)
Journal Article
Mistry, S. N., Marchand, P., & Kellam, B. (2019). Meeting report: 27th Annual GP2A Medicinal Chemistry Conference. Pharmaceuticals, 12(4), Article 179. https://doi.org/10.3390/ph12040179

The 27th annual GP2A (Groupement des Pharmacochimistes de l′Arc Atlantique/Group of Medicinal Chemists in the Atlantic Arc) conference took place from 21 to 23 August 2019, at the East Midlands Conference Centre (University Park, Nottingham, United K... Read More about Meeting report: 27th Annual GP2A Medicinal Chemistry Conference.

Protein Encapsulation of Experimental Anticancer Agents 5F 203 and Phortress: Towards Precision Drug Delivery (2019)
Journal Article
Breen, A. F., Scurr, D., Cassioli, M. L., Wells, G., Thomas, N. R., Zhang, J., Turyanska, L., & Bradshaw, T. D. (2019). Protein Encapsulation of Experimental Anticancer Agents 5F 203 and Phortress: Towards Precision Drug Delivery. International Journal of Nanomedicine, 14, 9525-9534. https://doi.org/10.2147/IJN.S226293

Introduction: Advancment of novel anticancer drugs into clinic is frequently halted by their lack of solubility, reduced stability under physiological conditions, and non-specific uptake by normal tissues, causing systemic toxicity. Their progress to... Read More about Protein Encapsulation of Experimental Anticancer Agents 5F 203 and Phortress: Towards Precision Drug Delivery.

An Overview of Pharmaceutical Production in Thai Hospitals (2019)
Journal Article
Pitchayajittipong, C., Sriboon, S., Kulmee, S., Prachuabaree, L., Srisawai, K., Wattanawong, W., Sripa, S., Anderson, C., & Supapaan, T. (2021). An Overview of Pharmaceutical Production in Thai Hospitals. Hospital Pharmacy, 56(4), 205-399. https://doi.org/10.1177/0018578719890090

Purpose:

The purpose of this research was to provide an overview of pharmaceutical production in Thai hospitals.

Methods:

A cross-sectional survey was developed to study pharmaceutical production in the 1347 Thai hospitals. A representati... Read More about An Overview of Pharmaceutical Production in Thai Hospitals.

Principal nested shape space analysis of molecular dynamics data (2019)
Journal Article
Dryden, I. L., Kim, K.-R., Laughton, C. A., & Le, H. (2019). Principal nested shape space analysis of molecular dynamics data. Annals of Applied Statistics, 13(4), 2213-2234. https://doi.org/10.1214/19-AOAS1277

Molecular dynamics simulations produce huge datasets of temporal sequences of molecules. It is of interest to summarize the shape evolution of the molecules in a succinct, low-dimensional representation. However, Euclidean techniques such as principa... Read More about Principal nested shape space analysis of molecular dynamics data.

In vivo delivery of VEGF RNA and protein to increase osteogenesis and intraosseous angiogenesis (2019)
Journal Article
Rumney, R. M. H., Lanham, S. A., Kanczler, J. M., Kao, A. P., Thiagarajan, L., Dixon, J. E., Tozzi, G., & Oreffo, R. O. C. (2019). In vivo delivery of VEGF RNA and protein to increase osteogenesis and intraosseous angiogenesis. Scientific Reports, 9(1), Article 17745. https://doi.org/10.1038/s41598-019-53249-4

Deficient bone vasculature is a key component in pathological conditions ranging from developmental skeletal abnormalities to impaired bone repair. Vascularisation is dependent upon vascular endothelial growth factor (VEGF), which drives both angioge... Read More about In vivo delivery of VEGF RNA and protein to increase osteogenesis and intraosseous angiogenesis.

Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome (2019)
Journal Article
Sander, K. N., Kim, D.-H., Ortori, C. A., Warren, A. Y., Anyanwagu, U. C., Hay, D. P., Pipkin, F. B., Khan, R. N., & Barrett, D. A. (2019). Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome. Metabolomics, 15, 1-10. https://doi.org/10.1007/s11306-019-1600-8

Introduction
Pre-eclampsia is a hypertensive gestational disorder that affects approximately 5% of all pregnancies.

Objectives
As the pathophysiological processes of pre-eclampsia are still uncertain, the present case–control study explored unde... Read More about Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome.

Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties (2019)
Journal Article
Okesola, B. O., Lau, H. K., Derkus, B., Boccorh, D. K., Wu, Y., Wark, A. W., Kiick, K. L., & Mata, A. (2020). Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties. Biomaterials Science, 8(3), 846-857. https://doi.org/10.1039/c9bm01796h

Covalent co-assembly holds great promise for the fabrication of hydrogels with controllable nanostructure, versatile chemical composition, and enhanced mechanical properties given its relative simplicity, high efficiency, and bond stability. This rep... Read More about Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties.

‘New Medicine Service’: supporting adherence in people starting a new medication for a long-term condition: 26-week follow-up of a pragmatic randomised controlled trial (2019)
Journal Article
Elliott, R. A., Boyd, M., Tanajewski, L., Barber, N., Gkountouras, G., Avery, A. J., Mehta, R., Davies, J. E., Salema, N.-E., Craig, C., Latif, A., Waring, J., & Chuter, A. (2019). ‘New Medicine Service’: supporting adherence in people starting a new medication for a long-term condition: 26-week follow-up of a pragmatic randomised controlled trial. BMJ Quality and Safety, 29(4), 286-295. https://doi.org/10.1136/bmjqs-2018-009177

Taking ELF off the shelf: Developing HE students’ speaking skills through a focus on English as a lingua franca (2019)
Journal Article
Dippold, D., Bridges, S., Eccles, S., & Mullen, E. (2019). Taking ELF off the shelf: Developing HE students’ speaking skills through a focus on English as a lingua franca. Linguistics and Education, 54, Article 100761. https://doi.org/10.1016/j.linged.2019.100761

This paper explores how principles derived from English as a lingua franca (ELF) research (e.g. accommodation, strategic competence) can provide insights into the speaking demands of group work in Anglophone EMI settings which includes native speaker... Read More about Taking ELF off the shelf: Developing HE students’ speaking skills through a focus on English as a lingua franca.