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All Outputs (12)

Non-inferiority trials in stroke research: what are they, and how should we interpret them? (2025)
Journal Article
Li, L., Lioutas, V.-A., Akyea, R. K., Gerner, S., Lau, K. K., Ramage, E., Katsanos, A. H., Howard, G., & Bath, P. M. (2025). Non-inferiority trials in stroke research: what are they, and how should we interpret them?. Journal of Stroke, 27(1), 41-51. https://doi.org/10.5853/jos.2024.03923

Randomized clinical trials are important in both clinical and academic stroke communities with increasing numbers of new design concepts emerging. One of the “less traditional” designs that have gained increasing interest in the last decade is non-in... Read More about Non-inferiority trials in stroke research: what are they, and how should we interpret them?.

Impact of SARS-CoV-2 Spike Antibody Positivity on Infection and Hospitalisation Rates in Immunosuppressed Populations during the Omicron Period: the MELODY study (2025)
Journal Article
Mumford, L., Hogg, R., Taylor, A., Lanyon, P., Bythell, M., McPhail, S., Chilcot, J., Powter, G., Cooke, G., Ward, H., Thomas, H., McAdoo, S. P., Lightstone, L., Lim, S. H., Pettigrew, G. J., Pearce, F. A., & Willicombe, M. (2025). Impact of SARS-CoV-2 Spike Antibody Positivity on Infection and Hospitalisation Rates in Immunosuppressed Populations during the Omicron Period: the MELODY study. Lancet, 405(10475), 314-328

Background
In the UK, booster COVID-19 vaccinations have been recommended biannually to people considered immune vulnerable. We investigated, at a population level, whether the absence of detectable anti-SARS-CoV-2 spike protein IgG antibody (anti-S... Read More about Impact of SARS-CoV-2 Spike Antibody Positivity on Infection and Hospitalisation Rates in Immunosuppressed Populations during the Omicron Period: the MELODY study.

Association of gestational day with antenatal management and the mortality and respiratory outcomes of extremely preterm infants (2025)
Journal Article
Kwok, T. C., Fiolna, M., Jones, N., Walker, K., & Sharkey, D. (2025). Association of gestational day with antenatal management and the mortality and respiratory outcomes of extremely preterm infants. Archives of Disease in Childhood. Fetal and Neonatal Edition, https://doi.org/10.1136/archdischild-2024-328066

Objective Perinatal epidemiological studies and outcomes are often reported on gestational week thresholds. This study aims to quantify and investigate the association of each gestational day at birth on antenatal management, mortality and respirator... Read More about Association of gestational day with antenatal management and the mortality and respiratory outcomes of extremely preterm infants.

Sexual and reproductive health needs of women with severe mental illness in low- and middle-income countries: A scoping review (2025)
Journal Article
Sisodia, S., Hammond, Z., Leonardi-Bee, J., Hanlon, C., & Asher, L. (2025). Sexual and reproductive health needs of women with severe mental illness in low- and middle-income countries: A scoping review. PLoS ONE, 20(1), Article e0311554. https://doi.org/10.1371/journal.pone.0311554

Background

This scoping review aimed to understand the extent and type of evidence in relation to sexual and reproductive health needs of women with severe mental illness (SMI) in low- and middle-income countries (LMIC) and to summarise those nee... Read More about Sexual and reproductive health needs of women with severe mental illness in low- and middle-income countries: A scoping review.

Sexual and reproductive health needs of women with severe mental illness in low- and middle-income countries: A scoping review (2025)
Journal Article
Sisodia, S., Hammond, Z., Leonardi-Bee, J., Hanlon, C., & Asher, L. (2025). Sexual and reproductive health needs of women with severe mental illness in low- and middle-income countries: A scoping review. PLoS ONE, 20(1), Article e0311554. https://doi.org/10.1371/journal.pone.0311554

Background

This scoping review aimed to understand the extent and type of evidence in relation to sexual and reproductive health needs of women with severe mental illness (SMI) in low- and middle-income countries (LMIC) and to summarise those nee... Read More about Sexual and reproductive health needs of women with severe mental illness in low- and middle-income countries: A scoping review.

Uptake and safety of Sotrovimab for prevention of severe COVID-19 in a cohort and self-controlled case series study (2025)
Journal Article
Patone, M., Snelling, A. J., Tibble, H., Coupland, C., Sheikh, A., & Hippisley-Cox, J. (2025). Uptake and safety of Sotrovimab for prevention of severe COVID-19 in a cohort and self-controlled case series study. Communications Medicine, 5(1), Article 20. https://doi.org/10.1038/s43856-024-00720-7

Background
Sotrovimab is a neutralising monoclonal antibody (nMAB) currently available to treat extremely clinically vulnerable COVID-19 patients in England. Trials have shown it to have mild to moderate side effects, however, evidence regarding its... Read More about Uptake and safety of Sotrovimab for prevention of severe COVID-19 in a cohort and self-controlled case series study.

Quantifying the portrayal of alcohol-related A&E attendances and prevention in the British medical documentary series ‘24 hours in A&E’ (2025)
Journal Article
Webster, K., Knight, H., & Morling, J. R. (2025). Quantifying the portrayal of alcohol-related A&E attendances and prevention in the British medical documentary series ‘24 hours in A&E’. Journal of Public Health, Article fdae314. https://doi.org/10.1093/pubmed/fdae314

Background
Alcohol misuse is linked to numerous health and socioeconomic harms. Edutainment and docutainment television programmes can act as health promotion tools, influencing health perceptions and behaviours. Inaccurate portrayals can engender m... Read More about Quantifying the portrayal of alcohol-related A&E attendances and prevention in the British medical documentary series ‘24 hours in A&E’.

Increasing lung screening uptake: Exploring people who smoke and their family members’ concerns and recommendations regarding screening invitations (2025)
Journal Article
Bell-Williams, R., Bains, M., Thorley, R., O' Dowd, E., Baldwin, D., & Murray, R. (2025). Increasing lung screening uptake: Exploring people who smoke and their family members’ concerns and recommendations regarding screening invitations. Tobacco Prevention & Cessation, 11(January), Article 1. https://doi.org/10.18332/tpc/194630

Introduction:
Challenges with designing invitation materials and accessing high risk communities are all factors in encouraging attendance at lung screening. This study focused on ways to improve participation in those potentially eligible for lung... Read More about Increasing lung screening uptake: Exploring people who smoke and their family members’ concerns and recommendations regarding screening invitations.

On Medical Tourism Overseas: Ethical Analysis of the Duties of NHS Doctors in Managing the Negative Health Consequences of Accessing Medical Treatments Abroad (2025)
Journal Article
Armitage, R. C. (2025). On Medical Tourism Overseas: Ethical Analysis of the Duties of NHS Doctors in Managing the Negative Health Consequences of Accessing Medical Treatments Abroad. Journal of Evaluation in Clinical Practice, 31(1), Article e14300. https://doi.org/10.1111/jep.14300

Introduction: An increasing number of UK residents are travelling overseas to access medical treatments, the negative health consequences of which are largely managed by NHS doctors. Methods: This paper performs an ethical analysis, using the ethical... Read More about On Medical Tourism Overseas: Ethical Analysis of the Duties of NHS Doctors in Managing the Negative Health Consequences of Accessing Medical Treatments Abroad.

Five year mortality in an RCT of a lung cancer biomarker to select people for low dose CT screening (2025)
Journal Article
Sullivan, F. M., Mair, F. S., Anderson, W., Chew, C., Dorward, A., Haughney, J., Hogarth, F., Kendrick, D., Littleford, R., McConnachie, A., McCowan, C., McMeekin, N., Patel, M., Rauchhaus, P., Daly, F., Ritchie, L., Robertson, J., Sarvesvaran, J., Sewell, H., Taylor, T., …Schembri, S. (2025). Five year mortality in an RCT of a lung cancer biomarker to select people for low dose CT screening. PLoS ONE, 20(1), Article e0306163. https://doi.org/10.1371/journal.pone.0306163

The role of biomarkers in risk-based early detection of lung cancer may enable screening to become cost effective and widely accessible. EarlyCDT-Lung is an example of such a blood-based autoantibody biomarker which may improve accessibility to Low d... Read More about Five year mortality in an RCT of a lung cancer biomarker to select people for low dose CT screening.

COLOFIT: Development and Internal-External Validation of Models Using Age, Sex, Faecal Immunochemical and Blood Tests to Optimise Diagnosis of Colorectal Cancer in Symptomatic Patients (2025)
Journal Article
Crooks, C. J., West, J., Jones, J., Hamilton, W., Bailey, S. E., Abel, G., Banerjea, A., Rees, C. J., Tamm, A., Nicholson, B. D., Benton, S. C., Hunt, N., COLOFIT, R. G., & Humes, D. J. (2025). COLOFIT: Development and Internal-External Validation of Models Using Age, Sex, Faecal Immunochemical and Blood Tests to Optimise Diagnosis of Colorectal Cancer in Symptomatic Patients. Alimentary Pharmacology and Therapeutics, https://doi.org/10.1111/apt.18459

Background: Colorectal cancer (CRC) is the third most common cancer in the United Kingdom and the second largest cause of cancer death. Aim: To develop and validate a model using available information at the time of faecal immunochemical testing (FIT... Read More about COLOFIT: Development and Internal-External Validation of Models Using Age, Sex, Faecal Immunochemical and Blood Tests to Optimise Diagnosis of Colorectal Cancer in Symptomatic Patients.

Using a novel smartphone app to track noise and vibration exposure during neonatal ambulance transport (2025)
Journal Article
Partridge, T., Leslie, A., Mistry, A., Simpson, R. B., Morris, D. E., McNally, D., Crowe, J., & Sharkey, D. (2025). Using a novel smartphone app to track noise and vibration exposure during neonatal ambulance transport. Archives of Disease in Childhood. Fetal and Neonatal Edition, https://doi.org/10.1136/archdischild-2024-327758

Objective To assess the utility of a bespoke smartphone app to map noise and vibration exposure across neonatal road ambulance journeys.

Design and setting Prospective observational study of ambulance journeys across a large UK neonatal transport... Read More about Using a novel smartphone app to track noise and vibration exposure during neonatal ambulance transport.