All Outputs (241)

Guillain–Barré Syndrome Variant Occurring after SARS-CoV-2 Vaccination (2021)
Journal Article
Allen, C. M., Ramsamy, S., Tarr, A. W., Tighe, P. J., Irving, W. L., Tanasescu, R., & Evans, J. R. (2021). Guillain–Barré Syndrome Variant Occurring after SARS-CoV-2 Vaccination. Annals of Neurology, 90(2), 315-318. https://doi.org/10.1002/ana.26144

Although SARS-CoV-2 vaccines are very safe, we report 4 cases of the bifacial weakness with paresthesias variant of Guillain–Barré syndrome (GBS) occurring within 3 weeks of vaccination with the Oxford–AstraZeneca SARS-CoV-2 vaccine. This rare neurol... Read More about Guillain–Barré Syndrome Variant Occurring after SARS-CoV-2 Vaccination.

Effect of intake of food hydrocolloids of bacterial origin on the glycemic response in humans: Systematic review and narrative synthesis (2021)
Journal Article
Alshammari, N. A., Taylor, M. A., Stevenson, R., Gouseti, O., Alyami, J., Muttakin, S., Bakalis, S., Lovegrove, A., Aithal, G. P., & Marciani, L. (2021). Effect of intake of food hydrocolloids of bacterial origin on the glycemic response in humans: Systematic review and narrative synthesis. Nutrients, 13(7), Article 2407. https://doi.org/10.3390/nu13072407

Diabetes mellitus is a chronic condition characterized by increased blood glucose levels from dysfunctional carbohydrate metabolism. Dietary intervention can help to prevent and manage the disease. Food hydrocolloids have been shown to have favorable... Read More about Effect of intake of food hydrocolloids of bacterial origin on the glycemic response in humans: Systematic review and narrative synthesis.

Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males (2021)
Journal Article
Quinlan, J. I., Franchi, M. V., Gharahdaghi, N., Badiali, F., Francis, S., Hale, A., Phillips, B. E., Szewczyk, N., Greenhaff, P. L., Smith, K., Maganaris, C., Atherton, P. J., & Narici, M. V. (2021). Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males. GeroScience, 43(4), 1567-1584. https://doi.org/10.1007/s11357-021-00396-0

Resistance exercise training (RET) is well-known to counteract negative age-related changes in both muscle and tendon tissue. Traditional RET consists of both concentric (CON) and eccentric (ECC) contractions; nevertheless, isolated ECC contractions... Read More about Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males.

Development of a Suite of Tools for Genome Editing in Parageobacillus thermoglucosidasius and Their Use to Identify the Potential of a Native Plasmid in the Generation of Stable Engineered Strains (2021)
Journal Article
Lau, M. S. H., Sheng, L., Zhang, Y., & Minton, N. P. (2021). Development of a Suite of Tools for Genome Editing in Parageobacillus thermoglucosidasius and Their Use to Identify the Potential of a Native Plasmid in the Generation of Stable Engineered Strains. ACS Synthetic Biology, 10(7), 1739-1749. https://doi.org/10.1021/acssynbio.1c00138

The relentless rise in the levels of atmospheric greenhouse gases caused by the exploitation of fossil fuel necessitates the development of more environmentally friendly routes to the manufacture of chemicals and fuels. The exploitation of a fermenta... Read More about Development of a Suite of Tools for Genome Editing in Parageobacillus thermoglucosidasius and Their Use to Identify the Potential of a Native Plasmid in the Generation of Stable Engineered Strains.

Gold–Oligonucleotide Nanoconstructs Engineered to Detect Conserved Enteroviral Nucleic Acid Sequences (2021)
Journal Article
Chauhan, V. M., Elsutohy, M. M., McClure, C. P., Irving, W. L., Roddis, N., & Aylott, J. W. (2021). Gold–Oligonucleotide Nanoconstructs Engineered to Detect Conserved Enteroviral Nucleic Acid Sequences. Biosensors, 11(7), Article 238. https://doi.org/10.3390/bios11070238

Enteroviruses are ubiquitous mammalian pathogens that can produce mild to life-threatening disease. We developed a multimodal, rapid, accurate and economical point-of-care biosensor that can detect nucleic acid sequences conserved amongst 96% of all... Read More about Gold–Oligonucleotide Nanoconstructs Engineered to Detect Conserved Enteroviral Nucleic Acid Sequences.

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition (2021)
Journal Article
Steketee, P. C., Dickie, E. A., Iremonger, J., Crouch, K., Paxton, E., Jayaraman, S., Alfituri, O. A., Awuah-Mensah, G., Ritchie, R., Schnaufer, A., Rowan, T., de Koning, H. P., Gadelha, C., Wickstead, B., Barrett, M. P., & Morrison, L. J. (2021). Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition. PLoS Pathogens, 17(7), Article e1009734. https://doi.org/10.1371/journal.ppat.1009734

Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucit... Read More about Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition.

In vivo Evaluation of a Newly Synthesized Acetylcholinesterase Inhibitor in a Transgenic Drosophila Model of Alzheimer’s Disease (2021)
Journal Article
Uras, G., Manca, A., Zhang, P., Markus, Z., Mack, N., Allen, S., Bo, M., Xu, S., Xu, J., Georgiou, M., & Zhu, Z. (2021). In vivo Evaluation of a Newly Synthesized Acetylcholinesterase Inhibitor in a Transgenic Drosophila Model of Alzheimer’s Disease. Frontiers in Neuroscience, 15, Article 691222. https://doi.org/10.3389/fnins.2021.691222

Alzheimer’s disease is a neurodegenerative disease characterized by disrupted memory, learning functions, reduced life expectancy, and locomotor dysfunction, as a result of the accumulation and aggregation of amyloid peptides that cause neuronal dama... Read More about In vivo Evaluation of a Newly Synthesized Acetylcholinesterase Inhibitor in a Transgenic Drosophila Model of Alzheimer’s Disease.

Varadia, a new helicarionoidean semi-slug genus from India's Western Ghats (Stylommatophora: Helicarionoidea) (2021)
Preprint / Working Paper
Varadia, a new helicarionoidean semi-slug genus from India's Western Ghats (Stylommatophora: Helicarionoidea)

We here describe a new Indian helicarionoidean genus, Varadia Bhosale & Raheem gen. nov., containing the single species Varadia amboliensis Bhosale, Thackeray, Muley & Raheem gen. et sp. nov. This new semi-slug is endemic to the northern and central... Read More about Varadia, a new helicarionoidean semi-slug genus from India's Western Ghats (Stylommatophora: Helicarionoidea).

Varadia, a new helicarionoidean semi-slug genus from India's Western Ghats (Stylommatophora: Helicarionoidea) (2021)
Preprint / Working Paper
Bhosale, A. R., Saadi, A. J., Wade, C. M., Thackeray, T., Tamboli, A. S., Kadam, S. K., Muley, D. V., & Raheem, D. C. (2021). Varadia, a new helicarionoidean semi-slug genus from India's Western Ghats (Stylommatophora: Helicarionoidea)

We here describe a new Indian helicarionoidean genus, Varadia Bhosale & Raheem gen. nov., containing the single species Varadia amboliensis Bhosale, Thackeray, Muley & Raheem gen. et sp. nov. This new semi-slug is endemic to the northern and central... Read More about Varadia, a new helicarionoidean semi-slug genus from India's Western Ghats (Stylommatophora: Helicarionoidea).

Governing plant-centred eating at the urban scale in the UK: The Sustainable Food Cities network and the reframing of dietary biopower (2021)
Journal Article
Morris, C., Kaljonen, M., & Hadley Kershaw, E. (2021). Governing plant-centred eating at the urban scale in the UK: The Sustainable Food Cities network and the reframing of dietary biopower. Geographical Journal, 188(3), Article 358-369. https://doi.org/10.1111/geoj.12388

Recent years have seen an increase in actions to address a key feature of food in the Anthropocene: the over-production and consumption of animal-based foods or “animalisation” of diets. However, it is unclear whether such efforts can be understood a... Read More about Governing plant-centred eating at the urban scale in the UK: The Sustainable Food Cities network and the reframing of dietary biopower.

Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages (2021)
Journal Article
Zeeshan, M., Pandey, R., Subudhi, A. K., Ferguson, D. J., Kaur, G., Rashpa, R., Nugmanova, R., Brady, D., Bottrill, A. R., Vaughan, S., Brochet, M., Bollen, M., Pain, A., Holder, A. A., Guttery, D. S., & Tewari, R. (2021). Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages. Communications Biology, 4(1), Article 760. https://doi.org/10.1038/s42003-021-02273-0

PP1 is a conserved eukaryotic serine/threonine phosphatase that regulates many aspects of mitosis and meiosis, often working in concert with other phosphatases, such as CDC14 and CDC25. The proliferative stages of the malaria parasite life cycle incl... Read More about Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages.

Fluorescent nanosensors reveal dynamic pH gradients during biofilm formation (2021)
Journal Article
Hollmann, B., Perkins, M., Chauhan, V. M., Aylott, J. W., & Hardie, K. R. (2021). Fluorescent nanosensors reveal dynamic pH gradients during biofilm formation. npj Biofilms and Microbiomes, 7(1), Article 50. https://doi.org/10.1038/s41522-021-00221-8

Understanding the dynamic environmental microniches of biofilms will permit us to detect, manage and exploit these communities. The components and architecture of biofilms have been interrogated in depth; however, little is known about the environmen... Read More about Fluorescent nanosensors reveal dynamic pH gradients during biofilm formation.

Large-scale genomic analysis reveals the genetic cost of chicken domestication (2021)
Journal Article
Wang, M. S., Zhang, J. J., Guo, X., Li, M., Meyer, R., Ashari, H., Zheng, Z. Q., Wang, S., Peng, M. S., Jiang, Y., Thakur, M., Suwannapoom, C., Esmailizadeh, A., Hirimuthugoda, N. Y., Zein, M. S. A., Kusza, S., Kharrati-Koopaee, H., Zeng, L., Wang, Y. M., Yin, T. T., …Zhang, Y. P. (2021). Large-scale genomic analysis reveals the genetic cost of chicken domestication. BMC Biology, 19(1), Article 118. https://doi.org/10.1186/s12915-021-01052-x

Background: Species domestication is generally characterized by the exploitation of high-impact mutations through processes that involve complex shifting demographics of domesticated species. These include not only inbreeding and artificial selection... Read More about Large-scale genomic analysis reveals the genetic cost of chicken domestication.

A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults (2021)
Journal Article
Templeman, I., Smith, H. A., Chowdhury, E., Chen, Y. C., Carroll, H., Johnson-Bonson, D., Hengist, A., Smith, R., Creighton, J., Clayton, D., Varley, I., Karagounis, L. G., Wilhelmsen, A., Tsintzas, K., Reeves, S., Walhin, J. P., Gonzalez, J. T., Thompson, D., & Betts, J. A. (2021). A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults. Science Translational Medicine, 13(598), Article 00. https://doi.org/10.1126/scitranslmed.abd8034

Intermittent fasting may impart metabolic benefits independent of energy balance by initiating fasting-mediated mechanisms. This randomized controlled trial examined 24-hour fasting with 150% energy intake on alternate days for 3 weeks in lean, healt... Read More about A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults.

Meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex (2021)
Journal Article
Shireby, G., Smith, R. G., Pishva, E., Smith, A. R., Roubroeks, J. A. Y., Hannon, E., Wheildon, G., Mastroeni, D., Gasparoni, G., Giese, A., Riemenschneider, M., Sharp, A. J., Schalkwyk, L., Haroutunian, V., Viechtbauer, W., Van Den Hove, D. L. A., Weedon, M., Brokaw, D., Francis, P. T., Thomas, A. J., …Lunnon, K. (2021). Meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex. Nature Communications, 12, Article 3517. https://doi.org/10.1038/s41467-021-23243-4

Epigenome-wide association studies of Alzheimer’s disease have highlighted neuropathology-associated DNA methylation differences, although existing studies have been limited in sample size and utilized different brain regions. Here, we combine data f... Read More about Meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex.

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores (2021)
Journal Article
de Rojas, I., Moreno-Grau, S., Tesi, N., Grenier-Boley, B., Andrade, V., Jansen, I. E., Pedersen, N. L., Stringa, N., Zettergren, A., Hernández, I., Montrreal, L., Antúnez, C., Antonell, A., Tankard, R. M., Bis, J. C., Sims, R., Bellenguez, C., Quintela, I., González-Perez, A., Calero, M., …PGC-ALZ consortia. (2021). Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores. Nature Communications, 12(1), Article 3417. https://doi.org/10.1038/s41467-021-22491-8

Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a l... Read More about Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores.

LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames (2021)
Journal Article
Blythe, M. J., Kocer, A., Rubio-Roldan, A., Giles, T., Abakir, A., Ialy-Radio, C., Wheldon, L. M., Bereshchenko, O., Bruscoli, S., Kondrashov, A., Drevet, J. R., Emes, R. D., Johnson, A. D., McCarrey, J. R., Gackowski, D., Olinski, R., Cocquet, J., Garcia-Perez, J. L., & Ruzov, A. (2021). LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames. Communications Biology, 4, Article 691. https://doi.org/10.1038/s42003-021-02217-8

Chromatin of male and female gametes undergoes a number of reprogramming events during the transition from germ cell to embryonic developmental programs. Although the rearrangement of DNA methylation patterns occurring in the zygote has been extensiv... Read More about LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames.

Biogeographic distribution of three phylotypes (T1, T2 and T6) of ammonia (foraminifera, Rhizaria) around Great Britain: new insights from combined molecular and morphological recognition (2021)
Journal Article
Richirt, J., Schweizer, M., Mouret, A., Quinchard, S., Saad, S. A., Bouchet, V. M. P., Wade, C. M., & Jorissen, F. J. (2021). Biogeographic distribution of three phylotypes (T1, T2 and T6) of ammonia (foraminifera, Rhizaria) around Great Britain: new insights from combined molecular and morphological recognition. Journal of Micropalaeontology, 40(1), 61-74. https://doi.org/10.5194/jm-40-61-2021

Ammonia is one of the most widespread foraminiferal genera worldwide. Three phylotypes (Ammonia sp. T1, T2 and T6), commonly encountered in the northeast Atlantic, are usually associated with the morphospecies Ammonia tepida. The biogeographic distri... Read More about Biogeographic distribution of three phylotypes (T1, T2 and T6) of ammonia (foraminifera, Rhizaria) around Great Britain: new insights from combined molecular and morphological recognition.

Modification of small ubiquitin-related modifier 2 (SUMO2) by phosphoubiquitin in HEK293T cells (2021)
Journal Article
Dongdem, J. T., Dawson, S. P., & Layfield, R. (2021). Modification of small ubiquitin-related modifier 2 (SUMO2) by phosphoubiquitin in HEK293T cells. Proteomics, 21(15), Article 2000234. https://doi.org/10.1002/pmic.202000234

Additional complexity in the post-translational modification of proteins by ubiquitin is achieved by ubiquitin phosphorylation, for example within PINK1-parkin mediated mitophagy. We performed a preliminary proteomic analysis to identify proteins dif... Read More about Modification of small ubiquitin-related modifier 2 (SUMO2) by phosphoubiquitin in HEK293T cells.

Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist D-serine (2021)
Journal Article
Dallérac, G., Li, X., Lecouflet, P., Morisot, N., Sacchi, S., Asselot, R., Pham, T. H., Potier, B., Watson, D. J. G., Schmidt, S., Levasseur, G., Fossat, P., Besedin, A., Rivet, J. M., Coyle, J. T., Collo, G., Pollegioni, L., Kehr, J., Galante, M., Fone, K. C., …Mothet, J. P. (2021). Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist D-serine. Proceedings of the National Academy of Sciences, 118(23), Article e2023750118. https://doi.org/10.1073/pnas.2023750118

Prefrontal control of cognitive functions critically depends upon glutamatergic transmission and N-methyl D-aspartate (NMDA) receptors, the activity of which is regulated by dopamine. Yet whether the NMDA receptor coagonist D-serine is implicated in... Read More about Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist D-serine.