All Outputs (241)

Study Protocol: The Heart and Brain Study (2021)
Journal Article
Suri, S., Bulte, D., Chiesa, S. T., Ebmeier, K. P., Jezzard, P., Rieger, S. W., Pitt, J. E., Griffanti, L., Okell, T. W., Craig, M., Chappell, M. A., Blockley, N. P., Kivimäki, M., Singh-Manoux, A., Khir, A. W., Hughes, A. D., Deanfield, J. E., Jensen, D. E. A., Green, S. F., Sigutova, V., …Mackay, C. E. (2021). Study Protocol: The Heart and Brain Study. Frontiers in Physiology, 12, Article 643725. https://doi.org/10.3389/fphys.2021.643725

Background: It is well-established that what is good for the heart is good for the brain. Vascular factors such as hypertension, diabetes, and high cholesterol, and genetic factors such as the apolipoprotein E4 allele increase the risk of developing... Read More about Study Protocol: The Heart and Brain Study.

Zebrafish as a tractable model of human cardiovascular disease (2021)
Journal Article
Bowley, G., Kugler, E., Wilkinson, R., Lawrie, A., Eeden, F., Chico, T. J. A., Evans, P. C., Noël, E. S., & Serbanovic‐Canic, J. (2022). Zebrafish as a tractable model of human cardiovascular disease. British Journal of Pharmacology, 179(5), 900-917. https://doi.org/10.1111/bph.15473

Mammalian models including non-human primates, pigs and rodents have been used extensively to study the mechanisms of cardiovascular disease. However, there is an increasing desire for alternative model systems that provide excellent scientific value... Read More about Zebrafish as a tractable model of human cardiovascular disease.

Mitigating the foreign body response through ‘immune-instructive’ biomaterials (2021)
Journal Article
Kämmerling, L., Fisher, L. E., Antmen, E., Simsek, G. M., Rostam, H. M., Vrana, N. E., & Ghaemmaghami, A. M. (2021). Mitigating the foreign body response through ‘immune-instructive’ biomaterials. Journal of Immunology and Regenerative Medicine, 12, Article 100040. https://doi.org/10.1016/j.regen.2021.100040

Objectives
Biomaterials are routinely used in clinical applications. A key to the clinical success of implanted biomaterials is not eliciting detrimental immune responses. In this article, we provide an overview of immune responses to biomaterials,... Read More about Mitigating the foreign body response through ‘immune-instructive’ biomaterials.

Novelty and Convergence in Adaptation to Whole Genome Duplication (2021)
Journal Article
Bohutínská, M., Alston, M., Monnahan, P., Mandáková, T., Bray, S., Paajanen, P., Kolář, F., & Yant, L. (2021). Novelty and Convergence in Adaptation to Whole Genome Duplication. Molecular Biology and Evolution, 38(9), 3910-3924. https://doi.org/10.1093/molbev/msab096

Whole genome duplication (WGD) can promote adaptation but is disruptive to conserved processes, especially meiosis. Studies in Arabidopsis arenosa revealed a coordinated evolutionary response to WGD involving interacting proteins controlling meiotic... Read More about Novelty and Convergence in Adaptation to Whole Genome Duplication.

Seasonal patterns in habitat use by the harvest mouse (Micromys minutus) and other small mammals (2021)
Journal Article
Occhiuto, F., Mohallal, E., Gilfillan, G. D., Lowe, A., & Reader, T. (2021). Seasonal patterns in habitat use by the harvest mouse (Micromys minutus) and other small mammals. Mammalia, 85(4), 325-335. https://doi.org/10.1515/mammalia-2020-0095

The ecology of the harvest mouse (Micromys minutus) is poorly understood, partly because it is a difficult species to monitor. It is commonly associated with reedbeds, where evidence suggests that it experiences strong seasonal fluctuations in abunda... Read More about Seasonal patterns in habitat use by the harvest mouse (Micromys minutus) and other small mammals.

Exploration of the 2016 Yellowstone River fish kill and proliferative kidney disease in wild fish populations (2021)
Journal Article
Hutchins, P. R., Sepulveda, A. J., Hartikainen, H., Staigmiller, K. D., Opitz, S. T., Yamamoto, R. M., Huttinger, A., Cordes, R. J., Weiss, T., Hopper, L. R., Purcell, M. K., & Okamura, B. (2021). Exploration of the 2016 Yellowstone River fish kill and proliferative kidney disease in wild fish populations. Ecosphere, 12(3), Article e03436. https://doi.org/10.1002/ecs2.3436

Proliferative kidney disease (PKD) is an emerging disease that recently resulted in a large mortality event of salmonids in the Yellowstone River (Montana, USA). Total PKD fish mortalities in the Yellowstone River were estimated in the tens of thousa... Read More about Exploration of the 2016 Yellowstone River fish kill and proliferative kidney disease in wild fish populations.

Trypanosome KKIP1 Dynamically Links the Inner Kinetochore to a Kinetoplastid Outer Kinetochore Complex (2021)
Journal Article
Brusini, L., D’Archivio, S., McDonald, J., & Wickstead, B. (2021). Trypanosome KKIP1 Dynamically Links the Inner Kinetochore to a Kinetoplastid Outer Kinetochore Complex. Frontiers in Cellular and Infection Microbiology, 11, Article 641174. https://doi.org/10.3389/fcimb.2021.641174

Kinetochores perform an essential role in eukaryotes, coupling chromosomes to the mitotic spindle. In model organisms they are composed of a centromere-proximal inner kinetochore and an outer kinetochore network that binds to microtubules. In spite o... Read More about Trypanosome KKIP1 Dynamically Links the Inner Kinetochore to a Kinetoplastid Outer Kinetochore Complex.

Human lung-on-chips: Advanced systems for respiratory virus models and assessment of immune response (2021)
Journal Article
Saygili, E., Yildiz-Ozturk, E., Green, M. J., Ghaemmaghami, A. M., & Yesil-Celiktas, O. (2021). Human lung-on-chips: Advanced systems for respiratory virus models and assessment of immune response. Biomicrofluidics, 15(2), Article 021501. https://doi.org/10.1063/5.0038924

Respiratory viral infections are leading causes of death worldwide. A number of human respiratory viruses circulate in all age groups and adapt to person-to-person transmission. It is vital to understand how these viruses infect the host and how the... Read More about Human lung-on-chips: Advanced systems for respiratory virus models and assessment of immune response.

Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens (2021)
Journal Article
Cook, R., Hooton, S., Trivedi, U., King, L., Dodd, C. E., Hobman, J. L., Stekel, D. J., Jones, M. A., & Millard, A. D. (2021). Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens. Microbiome, 9, Article 65. https://doi.org/10.1186/s40168-021-01010-3

Viruses are the most abundant biological entities on Earth, known to be crucial components of microbial ecosystems. However, there is little information on the viral community within agricultural waste. There are currently ~ 2.7 million dairy cattle... Read More about Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens.

Potentiated inhibition of Trichoderma virens and other environmental fungi by new biocide combinations (2021)
Journal Article
Vallières, C., Alexander, C., & Avery, S. V. (2021). Potentiated inhibition of Trichoderma virens and other environmental fungi by new biocide combinations. Applied Microbiology and Biotechnology, 105, 2867-2875. https://doi.org/10.1007/s00253-021-11211-3

Fungi cause diverse, serious socio-economic problems, including biodeterioration of valuable products and materials that spawns a biocides industry worth ~$11 billion globally. To help combat environmental fungi that commonly colonise material produc... Read More about Potentiated inhibition of Trichoderma virens and other environmental fungi by new biocide combinations.

Extracellular Vesicles and Intercellular Communication in the Central Nervous System (2021)
Journal Article
Lizarraga‐Valderrama, L. R., & Sheridan, G. K. (2021). Extracellular Vesicles and Intercellular Communication in the Central Nervous System. FEBS Letters, 595(10), 1391-1410. https://doi.org/10.1002/1873-3468.14074

Neurons and glial cells of the central nervous system (CNS) release extracellular vesicles (EVs) to the interstitial fluid of the brain and spinal cord parenchyma. EVs contain proteins, nucleic acids and lipids that can be taken up by, and modulate t... Read More about Extracellular Vesicles and Intercellular Communication in the Central Nervous System.

Fructose 1,6-bisphosphatase deficiency as a cause of childhood interstitial lung disease (2021)
Journal Article
Devaney, R., Simpson, T., Bush, A., Jagani, S., Nicholson, A. G., Semple, T., & Bhatt, J. M. (2021). Fructose 1,6-bisphosphatase deficiency as a cause of childhood interstitial lung disease. Pediatric Pulmonology, 56(7), 2362-2365. https://doi.org/10.1002/ppul.25362

Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A1 Receptor in Living Cells (2021)
Journal Article
Comeo, E., Trinh, P., Nguyen, A. T., Nowell, C. J., Kindon, N. D., Soave, M., Stoddart, L. A., White, J. M., Hill, S. J., Kellam, B., Halls, M. L., May, L. T., & Scammells, P. J. (2021). Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A1 Receptor in Living Cells. Journal of Medicinal Chemistry, 64(10), 6670-6695. https://doi.org/10.1021/acs.jmedchem.0c02067

The adenosine A1 receptor (A1AR) is a G-protein-coupled receptor (GPCR) that provides important therapeutic opportunities for a number of conditions including congestive heart failure, tachycardia, and neuropathic pain. The development of A1AR-select... Read More about Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A1 Receptor in Living Cells.

Analysis of sequence divergence in mammalian abcgs predicts a structural network of residues that underlies functional divergence (2021)
Journal Article
Mitchell-White, J. I., Stockner, T., Holliday, N., Briddon, S. J., & Kerr, I. D. (2021). Analysis of sequence divergence in mammalian abcgs predicts a structural network of residues that underlies functional divergence. International Journal of Molecular Sciences, 22(6), 1-16. https://doi.org/10.3390/ijms22063012

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. The five members of the mammalian G subfamily of ATP-binding cassette transporters differ greatly in their substrate specificity. Four members of the subfamily are important in lipid transport... Read More about Analysis of sequence divergence in mammalian abcgs predicts a structural network of residues that underlies functional divergence.

Development of a multiparametric (bio)sensing platform for continuous monitoring of stress metabolites (2021)
Journal Article
Chmayssem, A., Verplanck, N., Tanase, C. E., Costa, G., Monsalve-Grijalba, K., Amigues, S., Alias, M., Gougis, M., Mourier, V., Vignoud, S., Ghaemmaghami, A. M., & Mailley, P. (2021). Development of a multiparametric (bio)sensing platform for continuous monitoring of stress metabolites. Talanta, 229, Article 122275. https://doi.org/10.1016/j.talanta.2021.122275

There is a growing need for real-time monitoring of metabolic products that could reflect cell damages over extended periods. In this paper, we report the design and development of an original multiparametric (bio)sensing platform that is tailored fo... Read More about Development of a multiparametric (bio)sensing platform for continuous monitoring of stress metabolites.

Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study (2021)
Presentation / Conference Contribution
Briggs, L., Blake, H., Hassard, J., Cirelli, C., Daly, J., Corner, J., Bennett, M., Chappell, J., Fairclough, L., McClure, C., Tarr, A., Tighe, P., Favier, A., Irving, W., & Ball, J. (2021, March). Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study. Poster presented at MedAll International Virtual Medical Conference, Online

Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study (2021)
Presentation / Conference Contribution
Briggs, L., Blake, H., Cirelli, C., Corner, J., Hassard, J., Daly, J., Chappell, J., Bennett, M., Fairclough, L., McClure, C., Tarr, A., Tighe, P., Favier, A., Irving, W., & Ball, J. (2021, March). Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study. Poster presented at RSM National Conference 2021, Online

The use of fluorescence correlation spectroscopy to monitor cell surface β2‐adrenoceptors at low expression levels in human embryonic stem cell‐derived cardiomyocytes and fibroblasts (2021)
Journal Article
Goulding, J., Kondrashov, A., Mistry, S. J., Melarangi, T., Vo, N. T. N., Hoang, D. M., White, C. W., Denning, C., Briddon, S. J., & Hill, S. J. (2021). The use of fluorescence correlation spectroscopy to monitor cell surface β2‐adrenoceptors at low expression levels in human embryonic stem cell‐derived cardiomyocytes and fibroblasts. FASEB Journal, 35(4), Article e21398. https://doi.org/10.1096/fj.202002268r

The importance of cell phenotype in determining the molecular mechanisms underlying β2- adrenoceptor (β2AR) function has been noted previously when comparing responses in primary cells and recombinant model cell lines. Here, we have generated haploty... Read More about The use of fluorescence correlation spectroscopy to monitor cell surface β2‐adrenoceptors at low expression levels in human embryonic stem cell‐derived cardiomyocytes and fibroblasts.

Population genomic and historical analysis suggests a global invasion by bridgehead processes in Mimulus guttatus (2021)
Journal Article
Vallejo-Marín, M., Friedman, J., Twyford, A. D., Lepais, O., Ickert-Bond, S. M., Streisfeld, M. A., Yant, L., van Kleunen, M., Rotter, M. C., & Puzey, J. R. (2021). Population genomic and historical analysis suggests a global invasion by bridgehead processes in Mimulus guttatus. Communications Biology, 4(1), https://doi.org/10.1038/s42003-021-01795-x

© 2021, The Author(s). Imperfect historical records and complex demographic histories present challenges for reconstructing the history of biological invasions. Here, we combine historical records, extensive worldwide and genome-wide sampling, and de... Read More about Population genomic and historical analysis suggests a global invasion by bridgehead processes in Mimulus guttatus.

A Tryptophan ‘Gate’ in the CRISPR-Cas3 Nuclease Controls ssDNA Entry into the Nuclease Site, That When Removed Results in Nuclease Hyperactivity (2021)
Journal Article
He, L., Matošević, Z. J., Mitić, D., Markulin, D., Killelea, T., Matković, M., Bertoša, B., Ivančić-Baće, I., & Bolt, E. L. (2021). A Tryptophan ‘Gate’ in the CRISPR-Cas3 Nuclease Controls ssDNA Entry into the Nuclease Site, That When Removed Results in Nuclease Hyperactivity. International Journal of Molecular Sciences, 22(6), Article 2848. https://doi.org/10.3390/ijms22062848

Cas3 is a ssDNA-targeting nuclease-helicase essential for class 1 prokaryotic CRISPR immunity systems, which has been utilized for genome editing in human cells. Cas3-DNA crystal structures show that ssDNA follows a pathway from helicase domains into... Read More about A Tryptophan ‘Gate’ in the CRISPR-Cas3 Nuclease Controls ssDNA Entry into the Nuclease Site, That When Removed Results in Nuclease Hyperactivity.