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Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study (2020)
Journal Article
Hörner, D. V., Willingham, F. C., Selby, N. M., & Taal, M. W. (2020). Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study. Journal of Renal Nutrition, 30(6), 540-547. https://doi.org/10.1053/j.jrn.2019.12.006

Objective: Advanced glycation end-products (AGEs) are uremic toxins that result from oxidative stress and food consumption. We have previously reported that markers of malnutrition are more important determinants of increased skin autofluorescence (S... Read More about Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study.

A multi-centre study using comprehensive geriatric assessment to determine differences between older women with operable breast cancer undergoing surgery or non-operative treatment (2020)
Presentation / Conference Contribution
Parks, R., Howard, P., Zahit, R., Kayani, A., Lakshmanan, R., Tang, S., Hall, L., Blake, H., Morgan, D., Winterbottom, L., Jahan, M., & Cheung, K. A multi-centre study using comprehensive geriatric assessment to determine differences between older women with operable breast cancer undergoing surgery or non-operative treatment. Presented at 2nd UK Interdisciplinary Breast Cancer Symposium, Birmingham, UK

Aims/Objectives: Shared decision making on the choice of treatment for older women with breast cancer involves many factors. Comprehensive geriatric assessment (CGA) is recognised to have a role in older patients with cancer, but how this should be u... Read More about A multi-centre study using comprehensive geriatric assessment to determine differences between older women with operable breast cancer undergoing surgery or non-operative treatment.

Biological Variation of Cardiac Troponins in Chronic Kidney Disease (2020)
Journal Article
Jones, R., Barrett, J., Brettell, E., Cockwell, P., Dalton, R. N., Deeks, J., Eaglestone, G., Pellatt-Higgins, T., Kalra, P. A., Khunti, K., Morris, F., Ottridge, R., Sitch, A., Stevens, P. E., Sharpe, C., Sutton, A., Taal, M., & Lamb, E. J. (2020). Biological Variation of Cardiac Troponins in Chronic Kidney Disease. Annals of Clinical Biochemistry, 57(2), 162-169. https://doi.org/10.1177/0004563220906431

Background
Patients with chronic kidney disease often have increased plasma cardiac troponin concentration in the absence of myocardial infarction. Incidence of myocardial infarction is high in this population, and diagnosis, particularly of non ST-... Read More about Biological Variation of Cardiac Troponins in Chronic Kidney Disease.

Setting Priorities to Inform Assessment of Care Homes’ Readiness to Participate in Healthcare Innovation: A Systematic Mapping Review and Consensus Process (2020)
Journal Article
Bunn, F., Goodman, C., Corazzini, K., Sharpe, R., Handley, M., Lynch, J., Meyer, J., Dening, T., & Gordon, A. L. (2020). Setting Priorities to Inform Assessment of Care Homes’ Readiness to Participate in Healthcare Innovation: A Systematic Mapping Review and Consensus Process. International Journal of Environmental Research and Public Health, 17(3), Article 987. https://doi.org/10.3390/ijerph17030987

Organisational context is known to impact on the successful implementation of healthcare initiatives in care homes. We undertook a systematic mapping review to examine whether researchers have considered organisational context when planning, conducti... Read More about Setting Priorities to Inform Assessment of Care Homes’ Readiness to Participate in Healthcare Innovation: A Systematic Mapping Review and Consensus Process.

Association between non-malignant monoclonal gammopathy and adverse outcomes in chronic kidney disease: Acohort study (2020)
Journal Article
Fenton, A., Chinnadurai, R., Gullapudi, L., Kampanis, P., Dasgupta, I., Ritchie, J., Harding, S., Ferro, C. J., Kalra, P. A., Taal, M. W., & Cockwell, P. (2020). Association between non-malignant monoclonal gammopathy and adverse outcomes in chronic kidney disease: Acohort study. PLoS Medicine, 17(2), Article e1003050. https://doi.org/10.1371/journal.pmed.1003050

BACKGROUND: In studies including the general population, the presence of non-malignant monoclonal gammopathy (MG) can be causally associated with kidney damage and shorter survival. We assessed whether the presence of an MG is associated with a highe... Read More about Association between non-malignant monoclonal gammopathy and adverse outcomes in chronic kidney disease: Acohort study.

A Paradigm to Discover Biomarkers Associated With Chronic Kidney Disease Progression (2020)
Journal Article
Ali, I., Ibrahim, S. T., Chinnadurai, R., Green, D., Taal, M., Whetton, T. D., & Kalra, P. A. (2020). A Paradigm to Discover Biomarkers Associated With Chronic Kidney Disease Progression. Biomarker Insights, 15, 117727192097614. https://doi.org/10.1177/1177271920976146

Biomarker discovery in the field of risk prediction in chronic kidney disease (CKD) embraces the prospect of improving our ability to risk stratify future adverse outcomes and thereby guide patient care in a new era of personalised medicine. However,... Read More about A Paradigm to Discover Biomarkers Associated With Chronic Kidney Disease Progression.

The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles (2020)
Journal Article
Messa, G. A. M., Piasecki, M., Hurst, J., Hill, C., Tallis, J., & Degens, H. (2020). The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles. Journal of Experimental Biology, 223(6), Article jeb.217117. https://doi.org/10.1242/jeb.217117

© 2020. Published by The Company of Biologists Ltd. Prolonged high-fat diets (HFDs) can cause intramyocellular lipid (IMCL) accumulation that may negatively affect muscle function. We investigated the duration of a HFD required to instigate these cha... Read More about The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles.

Incidence and predictors of early seizures in intracerebral haemorrhage and the effect of tranexamic acid (2020)
Journal Article
Law, Z. K., England, T. J., Mistri, A. K., Woodhouse, L. J., Cala, L., Dineen, R., Ozturk, S., Beridze, M., Collins, R., Bath, P. M., Sprigg, N., & TICH-2 investigators. (2020). Incidence and predictors of early seizures in intracerebral haemorrhage and the effect of tranexamic acid. European Stroke Journal, 5(2), 123-129. https://doi.org/10.1177/2396987320901391

Introduction: Seizures are common after intracerebral haemorrhage. Tranexamic acid increases the risk of seizures in non-intracerebral haemorrhage population but its effect on post-intracerebral haemorrhage seizures is unknown. We explored the risk f... Read More about Incidence and predictors of early seizures in intracerebral haemorrhage and the effect of tranexamic acid.

Accuracy and clinical utility of comprehensive dysphagia screening assessments in acute stroke: A systematic review and meta‐analysis (2020)
Journal Article
Benfield, J. K., Everton, L. F., Bath, P. M., & England, T. J. (2020). Accuracy and clinical utility of comprehensive dysphagia screening assessments in acute stroke: A systematic review and meta‐analysis. Journal of Clinical Nursing, 29(9-10), 1527-1538. https://doi.org/10.1111/jocn.15192

Introduction

Nurses and other nonspecialists in dysphagia are often trained to screen swallowing poststroke. There are many basic tools that test water only, they are usually conservative, and patients that fail the test remain nil by mouth until... Read More about Accuracy and clinical utility of comprehensive dysphagia screening assessments in acute stroke: A systematic review and meta‐analysis.

Ethnic disparity in access to the memory assessment service between South Asian and white British older adults in the United Kingdom: A cohort study (2020)
Journal Article
Ogliari, G., Turner, Z., Khalique, J., Gordon, A. L., Gladman, J. R. F., & Chadborn, N. H. (2020). Ethnic disparity in access to the memory assessment service between South Asian and white British older adults in the United Kingdom: A cohort study. International Journal of Geriatric Psychiatry, 35(5), 507-515. https://doi.org/10.1002/gps.5263

Background: Equality of access to memory assessment services by older adults from ethnic minorities is both an ethical imperative and a public health priority.
Objective: To investigate whether timeliness of access to memory assessment service diffe... Read More about Ethnic disparity in access to the memory assessment service between South Asian and white British older adults in the United Kingdom: A cohort study.

Network analysis of human muscle adaptation to aging and contraction (2020)
Journal Article
Etheridge, T., Willis, C., Atherton, P., Ames, R., Szewczyk, N., Deane, C., Kadi, F., Phillips, B., Smith, K., Boereboom, C., Wilkinson, D., Abdulla, H., Williams, J., Bukhari, S., & Lund, J. (2020). Network analysis of human muscle adaptation to aging and contraction. Aging, 12(1), 740-755. https://doi.org/10.18632/aging.102653

Resistance exercise (RE) remains a primary approach for minimising aging muscle decline. Understanding muscle adaptation to individual contractile components of RE (eccentric, concentric) might optimise RE-based intervention strategies. Herein, we em... Read More about Network analysis of human muscle adaptation to aging and contraction.

Methodology and the professional doctorate – the muddy waters of knowledge creation, transfer and workplace capital (2020)
Journal Article
Smith, S. (2022). Methodology and the professional doctorate – the muddy waters of knowledge creation, transfer and workplace capital. Professional Development in Education, 48(2), 353-360. https://doi.org/10.1080/19415257.2020.1711800

The professional doctorate creates opportunities for shared research and novel findings to inform and shape the workplace and cultivate professional capital. In this paper I discuss my own journey in undertaking an Educational doctorate. I critique h... Read More about Methodology and the professional doctorate – the muddy waters of knowledge creation, transfer and workplace capital.

Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy (2019)
Journal Article
Luveta, J., Parks, R. M., Heery, D. M., Cheung, K.-L., & Johnston, S. J. (2020). Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy. Oncology and Therapy, 8, 1-11. https://doi.org/10.1007/s40487-019-00105-0

Invasive lobular carcinoma comprises 10–15% of all breast cancers and is increasingly recognised as a distinct and understudied disease compared with the predominant histological subtype, invasive ductal carcinoma. Hallmarks of invasive lobular carci... Read More about Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy.

Clinical characteristics and patient treatment satisfaction with Humalog U-200 in patients with type 2 diabetes mellitus: an observational study (2019)
Journal Article
Mamza, J., Anyanwagu, U., Alkharaiji, M., & Idris, I. (2020). Clinical characteristics and patient treatment satisfaction with Humalog U-200 in patients with type 2 diabetes mellitus: an observational study. Journal of Drug Assessment, 9(1), 8-12. https://doi.org/10.1080/21556660.2019.1704415

Background There is limited data on the real world evidence of Humalog 200 units/ml KwikPen (U-200) insulin. We assessed the use of U-200 insulin in UK routine clinical practice to provide information on clinical characteristics, treatment satisfacti... Read More about Clinical characteristics and patient treatment satisfaction with Humalog U-200 in patients with type 2 diabetes mellitus: an observational study.

Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT) (2019)
Journal Article
Robertson, J. F., Coleman, R. E., Cheung, K.-L., Evans, A., Holcombe, C., Skene, A., Rea, D., Ahmed, S., Jahan, A., Horgan, K., Rauchhaus, P., Littleford, R., Cheung, S. A., Cullberg, M., de Bruin, E. C., Koulai, L., Lindemann, J. P. O., Pass, M., Rugman, P., Schiavon, G., …Gee, J. M. (2020). Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT). Clinical Cancer Research, 26(7), 1574-1585. https://doi.org/10.1158/1078-0432.CCR-19-3053

© 2020 American Association for Cancer Research Inc.. All rights reserved. Purpose: The STAKT study examined short-term exposure (4.5 days) to the oral selective pan-AKT inhibitor capivasertib (AZD5363) to determine if this drug can reach its therape... Read More about Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT).

Coffee Consumption and Kidney Function: A Mendelian Randomization Study (2019)
Journal Article
Kennedy, O. J., Pirastu, N., Poole, R., Fallowfield, J. A., Hayes, P. C., Grzeszkowiak, E. J., Taal, M. W., Wilson, J. F., Parkes, J., & Roderick, P. J. (2020). Coffee Consumption and Kidney Function: A Mendelian Randomization Study. American Journal of Kidney Diseases, 75(5), 753-761. https://doi.org/10.1053/j.ajkd.2019.08.025

Rationale & Objective

Chronic kidney disease (CKD) is a leading cause of morbidity and mortality worldwide, with limited strategies for prevention and treatment. Coffee is a complex mixture of chemicals, and consumption has been associated with mo... Read More about Coffee Consumption and Kidney Function: A Mendelian Randomization Study.

Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome (2019)
Journal Article
Sander, K. N., Kim, D.-H., Ortori, C. A., Warren, A. Y., Anyanwagu, U. C., Hay, D. P., Pipkin, F. B., Khan, R. N., & Barrett, D. A. (2019). Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome. Metabolomics, 15, 1-10. https://doi.org/10.1007/s11306-019-1600-8

Introduction
Pre-eclampsia is a hypertensive gestational disorder that affects approximately 5% of all pregnancies.

Objectives
As the pathophysiological processes of pre-eclampsia are still uncertain, the present case–control study explored unde... Read More about Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome.

Personalising Care in the Older Woman with Primary Breast Cancer (2019)
Journal Article
Parks, R. M., & Cheung, K. L. (2019). Personalising Care in the Older Woman with Primary Breast Cancer. Annals of the Academy of Medicine, Singapore, 48(11), 370-375

The incidence of breast cancer increases with age. Despite this, most research in the field is targeted at younger patients. Age-specific guidelines are not widely referred to and guidelines which allude to the older woman as an individual are based... Read More about Personalising Care in the Older Woman with Primary Breast Cancer.