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Biology of oestrogen-receptor positive primary of core needle biopsy samples and correlation with clinical outcome (2020)
Journal Article
Parks, R. M., Albanghali, M., Syed, B. M., Green, A. R., Ellis, I. O., & Cheung, K. L. (2020). Biology of oestrogen-receptor positive primary of core needle biopsy samples and correlation with clinical outcome. Cancers, 12(8), Article 2067. https://doi.org/10.3390/cancers12082067

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The majority of biological profiling studies use surgical excision (SE) samples, excluding patients receiving nonsurgical and neoadjuvant therapy. We propose using core needle biopsy (CNB) for... Read More about Biology of oestrogen-receptor positive primary of core needle biopsy samples and correlation with clinical outcome.

Education of family members to support weaning to solids and nutrition in later infancy in term-born infants (2020)
Journal Article
Ojha, S., Elfzzani, Z., Kwok, T. C., & Dorling, J. (2020). Education of family members to support weaning to solids and nutrition in later infancy in term-born infants. Cochrane Database of Systematic Reviews, 2020(7), Article CD012241. https://doi.org/10.1002/14651858.cd012241.pub2

Review question

We reviewed the evidence for effects of nutrition education about appropriate feeding practices during weaning on growth and development in children born at term gestation.

Background

Around the world, over 150 million childr... Read More about Education of family members to support weaning to solids and nutrition in later infancy in term-born infants.

Absence of an ageing‐related increase in fibre type grouping in athletes and non‐athletes (2020)
Journal Article
Messa, G. A., Piasecki, M., Rittweger, J., McPhee, J. S., Koltai, E., Radak, Z., Simunic, B., Heinonen, A., Suominen, H., Korhonen, M. T., & Degens, H. (2020). Absence of an ageing‐related increase in fibre type grouping in athletes and non‐athletes. Scandinavian Journal of Medicine and Science in Sports, 30(11), 2057-2069. https://doi.org/10.1111/sms.13778

The ageing‐related loss of muscle mass is thought to be partly attributable to motor neuron loss and motor unit remodelling that result in fibre type grouping. We examined fibre type grouping in 19‐ to 85‐year‐old athletes and non‐athletes and evalua... Read More about Absence of an ageing‐related increase in fibre type grouping in athletes and non‐athletes.

Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the International Society of Geriatric Oncology (SIOG) COVID-19 Working Group (2020)
Journal Article
Battisti, N. M. L., Mislang, A. R., Cooper, L., O'Donovan, A., Audisio, R. A., Cheung, K. L., Sarrió, R. G., Stauder, R., Soto-Perez-de-Celis, E., Jaklitsch, M., Williams, G. R., O'Hanlon, S., Alam, M., Cairo, C., Colloca, G., Gil, L. A., Sattar, S., Kantilal, K., Russo, C., Lichtman, S. M., …Wildiers, H. (2020). Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the International Society of Geriatric Oncology (SIOG) COVID-19 Working Group. Journal of Geriatric Oncology, 11(8), 1190-1198. https://doi.org/10.1016/j.jgo.2020.07.008

© 2020 Elsevier Inc. The COVID-19 pandemic poses a barrier to equal and evidence-based management of cancer in older adults. The International Society of Geriatric Oncology (SIOG) formed a panel of experts to develop consensus recommendations on the... Read More about Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the International Society of Geriatric Oncology (SIOG) COVID-19 Working Group.

The management of adult appendicitis during the COVID-19 pandemic: an interim analysis of a UK cohort study (2020)
Journal Article
Javanmard-Emamghissi, H., Boyd-Carson, H., Hollyman, M., Doleman, B., Adiamah, A., Lund, J. N., Clifford, R., Dickerson, L., Richards, S., Pearce, L., Cornish, J., Hare, S., Lockwood, S., Moug, S. J., Tierney, G. M., & The COVID: HAREM (Had Appendicitis, Resolved/Recurred Emergency Morbidity/Mortality) Collaborators Group. (2021). The management of adult appendicitis during the COVID-19 pandemic: an interim analysis of a UK cohort study. Techniques in Coloproctology, 25(4), 401–411. https://doi.org/10.1007/s10151-020-02297-4

Background
Acute appendicitis (AA) is the most common general surgical emergency. Early laparoscopic appendicectomy is the gold-standard management. SARS-CoV-2 (COVID-19) brought concerns of increased perioperative mortality and spread of infection... Read More about The management of adult appendicitis during the COVID-19 pandemic: an interim analysis of a UK cohort study.

The association of skin autofluorescence with cardiovascular events and all-cause mortality in persons with chronic kidney disease stage 3: A prospective cohort study (2020)
Journal Article
Shardlow, A., McIntyre, N. J., Kolhe, N. V., Nellums, L. B., Fluck, R. J., McIntyre, C. W., & Taal, M. W. (2020). The association of skin autofluorescence with cardiovascular events and all-cause mortality in persons with chronic kidney disease stage 3: A prospective cohort study. PLoS Medicine, 17(7), e1003163. https://doi.org/10.1371/journal.pmed.1003163

A systematic review of minor phytocannabinoids with promising neuroprotective potential (2020)
Journal Article
Stone, N. L., Murphy, A. J., England, T. J., & O’Sullivan, S. E. (2020). A systematic review of minor phytocannabinoids with promising neuroprotective potential. British Journal of Pharmacology, 177(19), 4330-4352. https://doi.org/10.1111/bph.15185

Embase and PubMed were systematically searched for articles addressing the neuroprotective properties of phytocannabinoids, apart from cannabidiol and Δ9-tetrahydrocannabinol, including Δ9-tetrahydrocannabinolic acid, Δ9-tetrahydrocannabivarin, canna... Read More about A systematic review of minor phytocannabinoids with promising neuroprotective potential.

Flipping biomedical science (2020)
Book Chapter
Smith, S., & Khechara, M. (2020). Flipping biomedical science. In Z. Walker, D. Tan, & N. K. Koh (Eds.), Flipped classrooms with diverse learners (239-254). Springer. https://doi.org/10.1007/978-981-15-4171-1_14

Healthcare provision has undergone many changes over the past few decades driven by patient needs, advances in science and developing technologies. Within this framework, the role of individuals and the expectations placed upon the professions allied... Read More about Flipping biomedical science.

Research with older people in a world with COVID-19: identification of current and future priorities, challenges and opportunities (2020)
Journal Article
Richardson, S. J., Carroll, C. B., Close, J., Gordon, A. L., O’Brien, J., Quinn, T. J., Rochester, L., Sayer, A. A., Shenkin, S. D., van der Velde, N., Woo, J., & Witham, M. D. (2020). Research with older people in a world with COVID-19: identification of current and future priorities, challenges and opportunities. Age and Ageing, 49(6), 901–906. https://doi.org/10.1093/ageing/afaa149

Older people are disproportionately affected by the COVID-19 pandemic, which has had a profound impact on research as well as clinical service delivery. This commentary identifies key challenges and opportunities in continuing to conduct research wit... Read More about Research with older people in a world with COVID-19: identification of current and future priorities, challenges and opportunities.

Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single nucleotide polymorphisms in elite masters athletes (2020)
Journal Article
Crossland, H., Piasecki, J., McCormick, D., Phillips, B. E., Wilkinson, D. J., Smith, K., McPhee, J. S., Piasecki, M., & Atherton, P. J. (2020). Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single nucleotide polymorphisms in elite masters athletes. AJP - Regulatory, Integrative and Comparative Physiology, 319(2), R184-R194. https://doi.org/10.1152/ajpregu.00110.2020

Recent large genome-wide association studies (GWAS) have independently identified a set of genetic loci associated with lean body mass (LBM) and handgrip strength (HGS). Evaluation of these candidate single nucleotide polymorphisms (SNPs) may be usef... Read More about Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single nucleotide polymorphisms in elite masters athletes.

COVID-19 highlights the need for universal adoption of standards of medical care for physicians in nursing homes in Europe (2020)
Journal Article
O’Neill, D., Briggs, R., Holmerová, I., Samuelsson, O., Gordon, A. L., Martin, F. C., & The Special Interest Group in Long Term Care of the European Geriatric Medicine Society. (2020). COVID-19 highlights the need for universal adoption of standards of medical care for physicians in nursing homes in Europe. European Geriatric Medicine, 11(4), 645–650. https://doi.org/10.1007/s41999-020-00347-6

The nursing home sector has seen a disproportionately high number of deaths as part of the COVID-19 pandemic. This reflects, in part, the frailty and vulnerability of older people living in care homes but has also, in part, been a consequence of the... Read More about COVID-19 highlights the need for universal adoption of standards of medical care for physicians in nursing homes in Europe.

Protocol for a realist review of General Practitioners’ Role in Advancing Practice in Care Homes (GRAPE study) (2020)
Journal Article
Gordon, A. L., Devi, R., Williams, C., Goodman, C., Sartain, K., & Chadborn, N. H. (2020). Protocol for a realist review of General Practitioners’ Role in Advancing Practice in Care Homes (GRAPE study). BMJ Open, 10(6), Article e036221. https://doi.org/10.1136/bmjopen-2019-036221

Introduction
Older people who live in care homes have a high level of need with complex health conditions. In addition to providing medical care to residents, general practitioners (GPs) play a role as gatekeeper for access to services, as well as l... Read More about Protocol for a realist review of General Practitioners’ Role in Advancing Practice in Care Homes (GRAPE study).

A meta-analysis of remote ischaemic conditioning in experimental stroke (2020)
Journal Article
Weir, P., Maguire, R., O’Sullivan, S. E., & England, T. J. (2021). A meta-analysis of remote ischaemic conditioning in experimental stroke. Journal of Cerebral Blood Flow and Metabolism, 41(1), 3-13. https://doi.org/10.1177/0271678x20924077

Remote ischaemic conditioning (RIC) is achieved by repeated transient ischaemia of a distant organ/limb and is neuroprotective in experimental ischaemic stroke. However, the optimal time and methods of administration are unclear. Systematic review id... Read More about A meta-analysis of remote ischaemic conditioning in experimental stroke.

Uncovering the Devaluation of Nursing Home Staff During COVID-19: Are We Fuelling the Next Health Care Crisis? (2020)
Journal Article
Zúñiga, F., McGilton, K., Escrig-Pinol, A., Meyer, J., Gordon, A., Chu, C. H., Sanchez, M. G., Boscart, V., Corazzini, K. N., Jacinto, A. F., Spilsbury, K., Backman, A., Scales, K., Fagertun, A., Wu, B., Edvardsson, D., Lepore, M. J., Leung, A. Y., Siegel, E. O., Noguchi-Watanabe, M., …Bowers, B. (2020). Uncovering the Devaluation of Nursing Home Staff During COVID-19: Are We Fuelling the Next Health Care Crisis?. Journal of the American Medical Directors Association, 21(7), 962-965. https://doi.org/10.1016/j.jamda.2020.06.010

Special issues for older women with primary breast cancer (2020)
Journal Article
Parks, R. M., Jauhari, Y., Morgan, J., Wyld, L., & Cheung, K.-L. (2020). Special issues for older women with primary breast cancer. Breast Cancer Management, 9(3), Article BMT43. https://doi.org/10.2217/bmt-2020-0022

It is estimated that the number of older women living with breast cancer will quadruple by 2040. Despite this, there is a lack of strong evidence and guidelines to support management decisions for this population.

This article has evolved from a c... Read More about Special issues for older women with primary breast cancer.

Breast cancer surgery in older women: outcomes of the Bridging Age Gap in Breast Cancer study (2020)
Journal Article
Morgan, J. L., George, J., Holmes, G., Martin, C., Reed, M. W. R., Ward, S., Walters, S. J., Cheung, K. L., Audisio, R. A., Wyld, L., & Bridging the Age Gap Trial Management Team. (2020). Breast cancer surgery in older women: outcomes of the Bridging Age Gap in Breast Cancer study. British Journal of Surgery, https://doi.org/10.1002/bjs.11617

© 2020 The Authors. British Journal of Surgery published by John Wiley & Sons Ltd on behalf of BJS Society Ltd Background: Breast cancer surgery in older women is variable and sometimes non-standard owing to concerns about morbidity. Bridging the A... Read More about Breast cancer surgery in older women: outcomes of the Bridging Age Gap in Breast Cancer study.

Helping people to live well with chronic kidney disease (2020)
Journal Article
Fraser, S., & Taal, M. (2020). Helping people to live well with chronic kidney disease. British Journal of Hospital Medicine, 81(6), https://doi.org/10.12968/hmed.2020.0069

Reduced glomerular filtration rate and presence of albuminuria are both associated with increased risk of several poor outcomes. People with chronic kidney disease also commonly suffer from lower quality of life than their age-matched peers. The expe... Read More about Helping people to live well with chronic kidney disease.

The Landscape of Videofluoroscopy in the UK: A Web-Based Survey (2020)
Journal Article
Benfield, J. K., Michou, E., Everton, L. F., Mills, C., Hamdy, S., Bath, P. M., & England, T. J. (2021). The Landscape of Videofluoroscopy in the UK: A Web-Based Survey. Dysphagia, 36(2), 250-258. https://doi.org/10.1007/s00455-020-10130-1

Videofluoroscopy (VFS) is considered one of the gold-standard assessments of swallowing. Whilst guidelines for the application and conduct of VFS exist, their translation into clinical practice remain challenging. To build a greater understanding on... Read More about The Landscape of Videofluoroscopy in the UK: A Web-Based Survey.