All Outputs (38)

Associations Between Clinical Evidence of Inflammation and Synovitis in Symptomatic Knee Osteoarthritis: A Cross-Sectional Substudy (2016)
Journal Article
Wallace, G., Cro, S., Doré, C., King, L., Kluzek, S., Price, A., Roemer, F., Guermazi, A., Keen, R., & Arden, N. (2017). Associations Between Clinical Evidence of Inflammation and Synovitis in Symptomatic Knee Osteoarthritis: A Cross-Sectional Substudy. Arthritis Care and Research, 69(9), 1340-1348. https://doi.org/10.1002/acr.23162

Objective

Painful knee osteoarthritis (KOA) has been associated with joint inflammation. There is, however, little literature correlating signs of localized inflammation with contrast‐enhanced (CE) magnetic resonance imaging (MRI) of synovium. Thi... Read More about Associations Between Clinical Evidence of Inflammation and Synovitis in Symptomatic Knee Osteoarthritis: A Cross-Sectional Substudy.

Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial (2016)
Journal Article
Papou, A., Hussain, S., McWilliams, D. F., Zhang, W., & Doherty, M. (in press). Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial. Quality of Life Research, https://doi.org/10.1007/s11136-016-1484-2

Purpose. (1) to assess the responsiveness of the Short Form 36 Health Survey (SF-36) and Patient Generated Index (PGI) in people with knee pain who were given oral analgesics; and (2) to perform content analysis of the SF-36 and PGI aiming to identif... Read More about Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial.

Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study (2016)
Journal Article
Abhishek, A., Jenkins, W., La-Crette, J., Fernandes, G. S., & Doherty, M. (2016). Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study. Rheumatology, 56(4), https://doi.org/10.1093/rheumatology/kew395

Objectives: To evaluate the persistence and adherence on urate-lowering treatment (ULT) in primary care 5 years after an initial nurse-led treatment of gout.

Methods: One hundred gout patients initiated on up-titrated ULT between March and July 20... Read More about Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study.

Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families (2016)
Journal Article
Chou, I.-J., Kuo, C.-F., Huang, Y.-S., Grainge, M. J., Valdes, A. M., See, L.-C., Yu, K.-H., Luo, S.-F., Huang, L.-S., Tseng, W.-Y., Zhang, W., & Doherty, M. (in press). Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families. Schizophrenia Bulletin, https://doi.org/10.1093/schbul/sbw159

Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of... Read More about Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families.

Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain (2016)
Journal Article
Huang, J., Burston, J. J., Li, L., Ashraf, S., Mapp, P. I., Bennett, A. J., Ravipati, S., Pousinis, P., Barrett, D. A., Scammell, B. E., & Chapman, V. (2017). Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain. Arthritis and Rheumatology, 69(5), 996-1008. https://doi.org/10.1002/art.40001

Objective: Pain is a major symptom of osteoarthritis (OA); current analgesics either do not offer adequate pain relief or are associated with serious side effects. Herein we have investigated the therapeutic potential of targeting the resolvin recept... Read More about Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain.

Do smokers have greater risk of delayed and non-union after fracture, osteotomy and arthrodesis?: a systematic review with meta-analysis (2016)
Journal Article
Pearson, R. G., Clement, R., Edwards, K., & Scammell, B. E. (2016). Do smokers have greater risk of delayed and non-union after fracture, osteotomy and arthrodesis?: a systematic review with meta-analysis. BMJ Open, 6(11), Article e010303. https://doi.org/10.1136/bmjopen-2015-010303

Objectives: Systematic review and meta-analysis of published observational cohort studies. To quantify the increased risk smokers have of experiencing a delayed and/or non-union in fractures, spinal fusion, osteotomy, arthrodesis or established non-u... Read More about Do smokers have greater risk of delayed and non-union after fracture, osteotomy and arthrodesis?: a systematic review with meta-analysis.

Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis (2016)
Journal Article
Fu, Y., Persson, M. S., Bhattacharya, A., Goh, S.-L., Stocks, J., van Middelkoop, M., Bierma-Zeinstra, S. M., Walsh, D., Doherty, M., & Zhang, W. (2016). Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis. Systematic Reviews, 5(1), Article 183. https://doi.org/10.1186/s13643-016-0362-x

Background: The management of osteoarthritis (OA) is unsatisfactory, as most treatments are not clinically effective over placebo and most drugs have considerable side effects. On average, 75 % of the analgesic effect from OA treatments in clinical t... Read More about Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis.

Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature (2016)
Journal Article
Dell’Isola, A., Smith, S. L., Allan, R., Steultjens, M., & Marreiros, S. S. P. (2016). Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature. BMC Musculoskeletal Disorders, 17(1), Article 425. https://doi.org/10.1186/s12891-016-1286-2

Background

Knee Osteoarthritis (KOA) is a heterogeneous pathology characterized by a complex and multifactorial nature. It has been hypothesised that these differences are due to the existence of underlying phenotypes representing different mechan... Read More about Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature.

Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum? (2016)
Journal Article
Wilkes, S. R., Williams, H. C., Ormerod, A. D., Craig, F. E., Greenlaw, N., Norrie, J., Mitchell, E., Mason, J. M., & Thomas, K. S. (2016). Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum?. Journal of The American Academy of Dermatology, 75(6), 1216-1220.e2. https://doi.org/10.1016/j.jaad.2016.07.049

Background: Pyoderma gangrenosum is a rare inflammatory skin condition. The STOPGAP studies compared treatments for pyoderma gangrenosum using a primary outcome of healing speed at 6 weeks.
Objective: Using data from both studies we assessed the pre... Read More about Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum?.

Histopathological subgroups in knee osteoarthritis (2016)
Journal Article
Wyatt, L., Morerton, B., Mapp, P. I., Wilson, D., Hill, R., Ferguson, E., Scammell, B. E., & Walsh, D. A. (in press). Histopathological subgroups in knee osteoarthritis. Osteoarthritis and Cartilage, 25(1), https://doi.org/10.1016/j.joca.2016.09.021

Objective: Osteoarthritis (OA) is a heterogeneous, multi-tissue disease. We hypothesised that different histopathological features characterise different stages during knee OA progression, and that discrete subgroups can be defined based on validated... Read More about Histopathological subgroups in knee osteoarthritis.

Markers of synovial inflammation in cohorts at risk of knee osteoarthritis (2016)
Thesis
Kluzek, S. Markers of synovial inflammation in cohorts at risk of knee osteoarthritis. (Thesis). University of Oxford. https://nottingham-repository.worktribe.com/output/4471293

Background and objectives. Knee osteoarthritis (KOA) is a leading cause of disability in the developed world. Additionally, it is possibly linked with premature mortality. Low-grade inflammation is associated with a high risk of non-traumatic KOA inc... Read More about Markers of synovial inflammation in cohorts at risk of knee osteoarthritis.

Early clinical features in Systemic Lupus Erythematosus: can they be used to achieve earlier diagnosis?: a risk prediction model (2016)
Journal Article
Rees, F., Doherty, M., Lanyon, P., Davenport, G., Riley, R. D., Zhang, W., & Grainge, M. J. (2017). Early clinical features in Systemic Lupus Erythematosus: can they be used to achieve earlier diagnosis?: a risk prediction model. Arthritis Care and Research, 69(6), 833-841. https://doi.org/10.1002/acr.23021

OBJECTIVES: 1) To compare the primary care consulting behaviour prior to diagnosis of people with Systemic Lupus Erythematosus (SLE) with controls, 2) to develop and validate a risk prediction model to aid earlier SLE diagnosis.

METHODS: 1,739 in... Read More about Early clinical features in Systemic Lupus Erythematosus: can they be used to achieve earlier diagnosis?: a risk prediction model.

Ten minutes ergometer rowing exercise increases pressure pain thresholds in high performance rowers (2016)
Journal Article
Simpson, A., Pearson, R. G., & Scammell, B. (2016). Ten minutes ergometer rowing exercise increases pressure pain thresholds in high performance rowers. Annals of Sports Medicine and Research, 3(7), Article 1087

Background: Mechanical hypoalgesia has been demonstrated following bouts of acute exercise. The pain relieving properties of exercise thus have the potential to be utilised to help manage painful musculoskeletal conditions, such as osteoarthritis. Th... Read More about Ten minutes ergometer rowing exercise increases pressure pain thresholds in high performance rowers.

Resection and Resolution of Bone Marrow Lesions Associated with an Improvement of Pain after Total Knee Replacement: A Novel Case Study Using a 3-Tesla Metal Artefact Reduction MRI Sequence (2016)
Journal Article
Kurien, T., Kerslake, R., Haywood, B., Pearson, R. G., & Scammell, B. E. (2016). Resection and Resolution of Bone Marrow Lesions Associated with an Improvement of Pain after Total Knee Replacement: A Novel Case Study Using a 3-Tesla Metal Artefact Reduction MRI Sequence. Case Reports in Orthopedics, 2016, 1-5. https://doi.org/10.1155/2016/6043497

We present our case report using a novel metal artefact reduction magnetic resonance imaging (MRI) sequence to observe resolution of subchondral bone marrow lesions (BMLs), which are strongly associated with pain, in a patient after total knee replac... Read More about Resection and Resolution of Bone Marrow Lesions Associated with an Improvement of Pain after Total Knee Replacement: A Novel Case Study Using a 3-Tesla Metal Artefact Reduction MRI Sequence.

Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register (2016)
Journal Article
McWilliams, D. F., & Walsh, D. A. (2016). Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register. BMC Musculoskeletal Disorders, 17(1), Article 337. https://doi.org/10.1186/s12891-016-1192-7

Background: We examined pain levels in 2 cohorts assembled from the British Society for Rheumatology Biologics Register (BSRBR), and investigated which factors predicted Bodily Pain scores and discontinuation of TNFα-inhibitors.
Method: Data were re... Read More about Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register.

Strategies used for measuring long-term control in atopic dermatitis trials: A systematic review (2016)
Journal Article
Barbarot, S., Rogers, N. K., Abuabara, K., Aubert, H., Chalmers, J., Flohr, C., Hanfin, J., Naldi, L., Margolis, D. J., Paul, C., Ridd, M. J., Schuttelaar, M.-L. A., Simpson, E., Tauber, M., Volke, A., Weidinger, S., Wilkes, S. R., Wollenberg, A., & Thomas, K. S. (2016). Strategies used for measuring long-term control in atopic dermatitis trials: A systematic review. Journal of The American Academy of Dermatology, 75(5), https://doi.org/10.1016/j.jaad.2016.05.043

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease. There are no standardised methods for capturing long-term control of AD.

Objective: To identify how long-term control has been captured in published randomised controlled t... Read More about Strategies used for measuring long-term control in atopic dermatitis trials: A systematic review.

Functional outcome and complications following surgery for Dupuytren’s disease: a multi-centre cross-sectional study (2016)
Journal Article
Rodrigues, J., Zhang, W., Scammell, B. E., Chakrabarti, I., Russell, P., Fulllilove, S., Davidson, D., & Davis, T. (in press). Functional outcome and complications following surgery for Dupuytren’s disease: a multi-centre cross-sectional study. Journal of Hand Surgery (European Volume), https://doi.org/10.1177/1753193416660045

Variables associated with recurrent Dupuytren’s disease, or a ‘diathesis’, have been investigated, but those associated with functional outcome and complications are less well studied. Outcomes 1 or 5 years after an aponeurotomy, fasciectomy or derm... Read More about Functional outcome and complications following surgery for Dupuytren’s disease: a multi-centre cross-sectional study.

How Clinically Relevant Are Treatment Comparisons of Topical Calcineurin Inhibitor Trials for Atopic Eczema? (2016)
Journal Article
Wilkes, S. R., Nankervis, H., Tavernier, E., Maruani, A., & Williams, H. C. (2016). How Clinically Relevant Are Treatment Comparisons of Topical Calcineurin Inhibitor Trials for Atopic Eczema?. Journal of Investigative Dermatology, 136(10), 1944-1949. https://doi.org/10.1016/j.jid.2016.05.104

We sought to explore the architecture of trials of calcineurin inhibitors for atopic eczema to document the extent to which comparisons with active treatments such as topical corticosteroids (TCS) might have been included or avoided. We identified al... Read More about How Clinically Relevant Are Treatment Comparisons of Topical Calcineurin Inhibitor Trials for Atopic Eczema?.

Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative) (2016)
Journal Article
Chalmers, J., Simpson, E., Apfelbacher, C., Thomas, K., von Kobyletzki, L., Schmitt, J., Singh, J., Svensson, Å., Williams, H., Abuabara, K., Aoki, V., Ardeleanu, M., Awici-Rasmussen, M., Barbarot, S., Berents, T., Block, J., Bragg, A., Burton, T., Bjerring Clemmensen, K., Creswell-Melville, A., …Spuls, P. (2016). Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative). British Journal of Dermatology, 175(1), 69-79. https://doi.org/10.1111/bjd.14773

This article is a report of the fourth meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in Malmö, Sweden on 23–24 April 2015 (HOME IV). The aim of the meeting was to achieve consensus over the preferred outcome instrument... Read More about Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative).

Adequacy of Online Patient Information Resources on Gout and Potentially Curative Urate-Lowering Treatment (2016)
Journal Article
Jimenez-Liñan, L. M., Edwards, L., Abhishek, A., & Doherty, M. (2017). Adequacy of Online Patient Information Resources on Gout and Potentially Curative Urate-Lowering Treatment. Arthritis Care and Research, 69(5), 748-752. https://doi.org/10.1002/acr.22981

© 2016, American College of Rheumatology Objective: To assess the content and readability of online patient information resources against the current understanding of gout. Methods: An online survey was undertaken using Google UK, USA, Australia, and... Read More about Adequacy of Online Patient Information Resources on Gout and Potentially Curative Urate-Lowering Treatment.