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Development and validation of a prognostic model for predicting the risk of allopurinol-induced severe cutaneous adverse reactions: a retrospective new-user cohort study using linked primary care, hospitalisation, and mortality data (2025)
Journal Article
Cipolletta, E., Nakafero, G., Rozza, D., Mahil, S. K., Smith, C. H., Riley, R. D., & Abhishek, A. (2025). Development and validation of a prognostic model for predicting the risk of allopurinol-induced severe cutaneous adverse reactions: a retrospective new-user cohort study using linked primary care, hospitalisation, and mortality data. The Lancet Rheumatology, https://doi.org/10.1016/s2665-9913%2825%2900165-1

Background
Allopurinol, the most prescribed urate-lowering drug, is a known cause of severe cutaneous adverse reactions. We aimed to develop and validate a model to assess the risk of allopurinol-induced severe cutaneous adverse reactions in adults... Read More about Development and validation of a prognostic model for predicting the risk of allopurinol-induced severe cutaneous adverse reactions: a retrospective new-user cohort study using linked primary care, hospitalisation, and mortality data.

Validity and contributions to pain from the central aspects of pain questionnaire in rheumatoid arthritis (2025)
Journal Article
Smith, S., Georgopoulos, V., Sylvia Ifesemen, O., James, R., Ferguson, E., Wakefield, R. J., Wilson, D., Buckley, P., Platts, D., Ledbury, S., Choy, E., Pickles, T., Rutter-Locher, Z., Kirkham, B., Walsh, D., & McWilliams, D. (2025). Validity and contributions to pain from the central aspects of pain questionnaire in rheumatoid arthritis. PAIN Reports, 10(4), Article e1295. https://doi.org/10.1097/PR9.0000000000001295

Introduction:
The central nervous system (CNS) contributes to pain perception across musculoskeletal conditions. The central aspects of pain (CAP) questionnaire captures a single score associated with quantitative sensory testing (QST) evidence of... Read More about Validity and contributions to pain from the central aspects of pain questionnaire in rheumatoid arthritis.

Negotiating Critical Tensions: Creating an Online Resource on Vaccine Hesitancy for Healthcare Professionals (2025)
Journal Article
Emerson, T., & Hobson-West, P. (2025). Negotiating Critical Tensions: Creating an Online Resource on Vaccine Hesitancy for Healthcare Professionals. Sociological Research Online, https://doi.org/10.1177/1360780425135113

Vaccine hesitancy is regarded as a priority for public health and has a long history of social science research. As part of a qualitative project on childhood vaccine hesitancy, a team of social scientists translated their empirical findings into an... Read More about Negotiating Critical Tensions: Creating an Online Resource on Vaccine Hesitancy for Healthcare Professionals.

Piloting a Minimum Data Set (MDS) in English care homes: a qualitative study of professional perspectives on implementation and data use (2025)
Journal Article
Carroll, R. E., Smith, N., ER Palmer, S., Kirsty Burton, J., Lee Gordon, A., Towers, A.-M., Rand, S. E., Tracey, F., Killett, A., Webster, L., Hanratty, B., Spilsbury, K., Akdur, G., De Corte, K., Meyer, J. E., Jones, L., & Goodman, C. (2025). Piloting a Minimum Data Set (MDS) in English care homes: a qualitative study of professional perspectives on implementation and data use. BMC Geriatrics, 25, Article 604

Background
Digitalisation within English care homes offers potential to make more effective use of substantial data collected by staff during care planning and recording. A pilot minimum data set was co-designed with stakeholders based on two digita... Read More about Piloting a Minimum Data Set (MDS) in English care homes: a qualitative study of professional perspectives on implementation and data use.

Development of a digital, self-guided return-to-work toolkit for stroke survivors and employers using intervention mapping (2025)
Journal Article
Craven, K., Holmes, J., Kettlewell, J., & Radford, K. (2025). Development of a digital, self-guided return-to-work toolkit for stroke survivors and employers using intervention mapping. PLOS Digital Health, 4(8), Article e0000971. https://doi.org/10.1371/journal.pdig.0000971

Stroke incidence is rising among working-age adults in high-income countries. Employers often lack knowledge and skills to support return-to-work post-stroke. In the United Kingdom, nearly 40% of stroke survivors stop working. Vocational rehabilitati... Read More about Development of a digital, self-guided return-to-work toolkit for stroke survivors and employers using intervention mapping.

Surgery versus non-surgical splint treatment for proximal phalanx shaft finger fractures in adults: the POINT Randomised Controlled Trial (2025)
Journal Article
Karantana, A., White, J., Bradshaw, L., Davis, T., Godfrey, M., James, M., Jarrett, H., Jerosch-Herold, C., Ogollah, R., Roadevin, C., Rodrigues, J., Sprange, K., Trickett, R., Costa, M., & Montgomery, A. (in press). Surgery versus non-surgical splint treatment for proximal phalanx shaft finger fractures in adults: the POINT Randomised Controlled Trial. Health Technology Assessment, https://doi.org/10.3310/GJAK6715

Exploring the impact of short-term adherence to physical activity guidelines to improve the intrinsic capacity of older adults (2025)
Journal Article
Carrick, L., Doleman, B., Gates, A., Pabla, P., Lund, J. N., Williams, J. P., & Phillips, B. E. (2025). Exploring the impact of short-term adherence to physical activity guidelines to improve the intrinsic capacity of older adults. Translational Exercise Biomedicine, https://doi.org/10.1515/teb-2025-0019

Objectives
Cardiorespiratory fitness (CRF) and skeletal muscle mass (SMM) are both key parameters of intrinsic capacity. To date, the impact of adherence to physical activity guidelines by older adults on these facets is poorly understood. Therefore... Read More about Exploring the impact of short-term adherence to physical activity guidelines to improve the intrinsic capacity of older adults.

Development of theory-based text message prompts to promote engagement with a workplace digital intervention (pain-at-work toolkit) using the com-b model (2025)
Presentation / Conference Contribution
Chaplin, W. J., Porter, L., Kouraki, A., Salimian, M., Dellow, V., Abbott-Fleming, V., Wainwright, E., Taylor, G., McNamee, P., McWilliams, D., Walsh, D., Walker-Bone, K., & Blake, H. (2025, June). Development of theory-based text message prompts to promote engagement with a workplace digital intervention (pain-at-work toolkit) using the com-b model. Presented at 17th International Conference on Education and New Learning Technologies, Palma, Spain

Chronic pain, affecting over a quarter of the UK workforce, places a high economic burden on individuals, employers, and healthcare services. The Pain-at-Work (PAW) Toolkit is a digital intervention which aims to provide education and self-management... Read More about Development of theory-based text message prompts to promote engagement with a workplace digital intervention (pain-at-work toolkit) using the com-b model.

Discontinuation of menopausal hormone therapy and risk of fracture: nested case-control studies using routinely collected primary care data (2025)
Journal Article
Vinogradova, Y., Iyen, B., Masud, T., Taylor, L., & Kai, J. (2025). Discontinuation of menopausal hormone therapy and risk of fracture: nested case-control studies using routinely collected primary care data. The Lancet Healthy Longevity, 6(7), Article 100729

Background
Women benefit from reduced fracture risk while using menopausal hormone therapy. However, information on risks after stopping menopausal hormone therapy is scarce and inconsistent, with no information on longer-term fracture risk as women... Read More about Discontinuation of menopausal hormone therapy and risk of fracture: nested case-control studies using routinely collected primary care data.

Common inflammatory proteins linking frailty and area-level deprivation as key drivers of cardiovascular risk in women (2025)
Journal Article
Lin, Y., Louca, P., Bowyer, R. C., Kouraki, A., Rossi, N., Ni Lochlainn, M., Kelly, A., Georgopoulos, V., Williams, F. M., J. Steves, C., Falchi, M., Valdes, A. M., & Menni, C. (2025). Common inflammatory proteins linking frailty and area-level deprivation as key drivers of cardiovascular risk in women. Communications Medicine, 5, Article 301. https://doi.org/10.1038/s43856-025-01012-4

Background

Chronic inflammation is linked to frailty and deprivation, both of which are comorbid with cardiovascular diseases (CVD). This study aims to identify inflammatory proteins associated with both socioeconomic deprivation and frailty, and... Read More about Common inflammatory proteins linking frailty and area-level deprivation as key drivers of cardiovascular risk in women.

Development and description of Early Stroke Specialist Vocational Rehabilitation (ESSVR) delivered in the Return to work after stroke (RETAKE) Trial (2025)
Journal Article
Radford, K. A., Grant, M. I., Holmes, J. A., Phillips, J., Powers, K., Chambers, R. L., Craven, K., Bell, B., Mckevitt, C., Clarke, D. J., Farrin, A. J., Trusson, D., Watkins, C. L., Bowen, A., Thompson, E., & Wright-Hughes, A. (in press). Development and description of Early Stroke Specialist Vocational Rehabilitation (ESSVR) delivered in the Return to work after stroke (RETAKE) Trial. Health Technology Assessment,

Neural Mechanisms and Alterations of Sweet Sensing: Insights from Functional Magnetic Resonance Imaging Studies (2025)
Journal Article
Long, T., Milbourn, C. C., Smith, A., Linn Su Khin, K., Page, A. J., Idris, I., Yang, Q., Young, R. L., & Eldeghaidy, S. (2025). Neural Mechanisms and Alterations of Sweet Sensing: Insights from Functional Magnetic Resonance Imaging Studies. Life, 15(7), Article 1075. https://doi.org/10.3390/life15071075

Sweet sensing is a fundamental sensory experience that plays a critical role not only in food preference, reward and dietary behaviour but also in glucose metabolism. Sweet taste receptors (STRs), composed of a heterodimer of taste receptor type 1 me... Read More about Neural Mechanisms and Alterations of Sweet Sensing: Insights from Functional Magnetic Resonance Imaging Studies.

Exploring stroke survivor and employer experiences of disruption within the RETurn to work After stroKE (RETAKE) trial during the COVID-19 pandemic (2025)
Journal Article
Trusson, D., Powers, K., Radford, K., Bowen, A., Craven, K., Farrin, A., McKevitt, C., Murray, J., Phillips, J., Stevens, J., & Clarke, D. (2025). Exploring stroke survivor and employer experiences of disruption within the RETurn to work After stroKE (RETAKE) trial during the COVID-19 pandemic. Frontiers in Sociology, 10, Article 1434353. https://doi.org/10.3389/fsoc.2025.1434353

Introduction: Returning to work is a goal for many stroke survivors, with benefits for individuals and society. The ReTurn to work After stroKE (RETAKE) trial, which aimed to improve stroke survivors’ work outcomes through early stroke-specific vocat... Read More about Exploring stroke survivor and employer experiences of disruption within the RETurn to work After stroKE (RETAKE) trial during the COVID-19 pandemic.

ESTABLISHING PROOF-OF-CONCEPT FOR THE PAIN-AT-WORK TOOLKIT: A DIGITAL INTERVENTION TO SUPPORT PEOPLE AT WORK WITH CHRONIC PAIN (2025)
Presentation / Conference Contribution
Blake, H., Abbott-Fleming, V., Chaplin, W. J., Wainwright, E., Taylor, G., McNamee, P., McWilliams, D., Walsh, D., & Walker-Bone, K. (2025, June). ESTABLISHING PROOF-OF-CONCEPT FOR THE PAIN-AT-WORK TOOLKIT: A DIGITAL INTERVENTION TO SUPPORT PEOPLE AT WORK WITH CHRONIC PAIN. Presented at 17th International Conference on Education and New Learning Technologies, Palma, Spain

Chronic pain affects over a quarter of the workforce with high economic burden for individuals, employers and healthcare services. Providing education and advice to people with chronic pain about self-management strategies is recommended within clini... Read More about ESTABLISHING PROOF-OF-CONCEPT FOR THE PAIN-AT-WORK TOOLKIT: A DIGITAL INTERVENTION TO SUPPORT PEOPLE AT WORK WITH CHRONIC PAIN.

Assessing the fidelity of adjunct opt-in support calls for participants in the Pain-at-Work feasibility trial (2025)
Presentation / Conference Contribution
Chaplin, W. J., Porter, L., Holmes, J., Abbott-Fleming, V., Wainwright, E., Taylor, G., McNamee, P., McWilliams, D., Walsh, D., Walker-Bone, K., & Blake, H. (2025, June). Assessing the fidelity of adjunct opt-in support calls for participants in the Pain-at-Work feasibility trial. Presented at 17th International Conference on Education and New Learning Technologies, Palma, Spain

Chronic pain affects over a quarter of the UK workforce with a high economic burden for individuals, employers and healthcare services. The Pain-at-Work (PAW) feasibility trial is a cluster randomised controlled trial (cRCT) to assess the feasibility... Read More about Assessing the fidelity of adjunct opt-in support calls for participants in the Pain-at-Work feasibility trial.

Optimising access to vocational rehabilitation through multiple sclerosis charities: Protocol for a feasibility randomised controlled trial (2025)
Journal Article
De Dios Perez, B., Kendrick, D., das Nair, R., Evangelou, N., Newsome, I., & Radford, K. (2025). Optimising access to vocational rehabilitation through multiple sclerosis charities: Protocol for a feasibility randomised controlled trial. PLoS ONE, 20(6), Article e0325570. https://doi.org/10.1371/journal.pone.0325570

Background

People with multiple sclerosis (MS) often leave the workforce prematurely due to MS symptoms and difficulties managing workplace relationships and performance. Vocational rehabilitation (VR) can improve job retention outcomes for people... Read More about Optimising access to vocational rehabilitation through multiple sclerosis charities: Protocol for a feasibility randomised controlled trial.

Co-designing and testing a management programme with peer support for post-stroke fatigue: Nottingham fatigue after stroke study (NotFAST3) (2025)
Journal Article
Ablewhite, J., Thomas, S., das Nair, R., Jones, F., Sprigg, N., Wharrad, H., & Drummond, A. (2025). Co-designing and testing a management programme with peer support for post-stroke fatigue: Nottingham fatigue after stroke study (NotFAST3). Clinical Rehabilitation, 39(8), 1080-1091. https://doi.org/10.1177/02692155251350084

Objective: To develop and test a novel programme to support post-stroke fatigue management for testing in a future clinical trial. Design: Staged approach to development and preliminary testing. Phases 1 and 2: co-design groups held to agree programm... Read More about Co-designing and testing a management programme with peer support for post-stroke fatigue: Nottingham fatigue after stroke study (NotFAST3).

The legacy effect of early HbA1c control on microvascular complications and hospital admissions in type 2 diabetes: findings from a large UK study (2025)
Journal Article
Aldafas, R., Vinogradova, Y., Crabtree, T. S. J., Gordon, J., & Idris, I. (2025). The legacy effect of early HbA1c control on microvascular complications and hospital admissions in type 2 diabetes: findings from a large UK study. Therapeutic Advances in Endocrinology and Metabolism, 16, 1-14. https://doi.org/10.1177/20420188251350897

Introduction
There is conflicting evidence regarding optimal glycaemic targets to reflect the legacy effect of hyperglycaemia in people with type 2 diabetes (T2D). We examined the risks of microvascular complications and hospital admission with HbA... Read More about The legacy effect of early HbA1c control on microvascular complications and hospital admissions in type 2 diabetes: findings from a large UK study.

Validity and contributions to pain from the central aspects of pain questionnaire in rheumatoid arthritis (2025)
Journal Article
Smith, S., Georgopoulos, V., Ifesemen, O., James, R., Ferguson, E., Wakefield, R., Wilson, D., Buckley, P., Platts, D., Ledbury, S., Choy, E., Pickles, T., Rutter-Locher, Z., Kirkham, B., Walsh, D., & McWilliams, D. (2025). Validity and contributions to pain from the central aspects of pain questionnaire in rheumatoid arthritis. PAIN Reports, 10(4), Article e1295. https://doi.org/10.1097/PR9.0000000000001295

Introduction:

The central nervous system (CNS) contributes to pain perception across musculoskeletal conditions. The central aspects of pain (CAP) questionnaire captures a single score associated with quantitative sensory testing (QST) evidence o... Read More about Validity and contributions to pain from the central aspects of pain questionnaire in rheumatoid arthritis.