All Outputs (63)

Design, synthesis and biological evaluation of novel nitric oxidedonating protoberberine derivatives as antitumor agents (2017)
Journal Article
Chen, J., Wang, T., Xu, S., Lin, A., Yao, H., Xie, W., …Xu, J. (2017). Design, synthesis and biological evaluation of novel nitric oxidedonating protoberberine derivatives as antitumor agents. European Journal of Medicinal Chemistry, 132, https://doi.org/10.1016/j.ejmech.2017.03.027

A novel class of NO-donating protoberberine derivatives were synthesized and initially evaluated for their anti-hepatocellular carcinoma activities. Most of the compounds exhibited more potent activity against HepG2 cells than parent compounds berber... Read More about Design, synthesis and biological evaluation of novel nitric oxidedonating protoberberine derivatives as antitumor agents.

Antioxidant properties of novel dimers derived from natural ??elemene through inhibiting H2O2?induced apoptosis (2017)
Journal Article
Chen, J., Wang, R., Wang, T., Ding, Q., Khalil, A., Xu, S., …Xu, J. (in press). Antioxidant properties of novel dimers derived from natural β‑elemene through inhibiting H2O2‑induced apoptosis. ACS Medicinal Chemistry Letters, 8(4), https://doi.org/10.1021/acsmedchemlett.7b00035

A series of novel ?-elemene dimer derivatives were synthesized and evaluated for their antioxidant activities. The results indicated that most of the target compounds showed more potent cytoprotective effects than positive control vitamin E. In parti... Read More about Antioxidant properties of novel dimers derived from natural ??elemene through inhibiting H2O2?induced apoptosis.

The structural modification of natural products for novel drug discovery (2016)
Journal Article
Yao, H., Liu, J., Xu, S., Zhu, Z., & Xu, J. (in press). The structural modification of natural products for novel drug discovery. Expert Opinion on Drug Discovery, 12(2), https://doi.org/10.1080/17460441.2016.1272757

Introduction: Throughout history, natural products (NPs) have provided a rich source of compounds that have wide applications in the fields of medicine, health sciences, pharmacy and biology. Although naturally active substances are good lead compoun... Read More about The structural modification of natural products for novel drug discovery.