Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models
(2009)
Journal Article
Orihuela, C. J., Mahdavi, J., Thornton, J., Mann, B., Wooldridge, K. G., Abouseada, N., Oldfield, N. J., Self, T., Ala'Aldeen, D. A., & Tuomanen, E. I. (2009). Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models. Journal of Clinical Investigation, 119(6), 1638-1646. https://doi.org/10.1172/JCI36759
A diverse array of infectious agents, including prions and certain neurotropic viruses, bind to the laminin receptor (LR), and this determines tropism to the CNS. Bacterial meningitis in childhood is almost exclusively caused by the respiratory tract... Read More about Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models.