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Pneumococcal pneumonia trends in adults hospitalised with community-acquired pneumonia over 10 years (2013-2023) and the role of serotype 3 (2024)
Journal Article
Lansbury, L., McKeever, T. M., Lawrence, H., Pick, H., Baskaran, V., Edwards-Pritchard, R. C., Matthews, L., Bailey, H., Ashton, D., Bendall, L., Rodrigo, C., Daniel, P., Litt, D., Eletu, S., Parmar, H., Sheppard, C. L., Ladhani, S., Trotter, C., & Lim, W. S. (2025). Pneumococcal pneumonia trends in adults hospitalised with community-acquired pneumonia over 10 years (2013-2023) and the role of serotype 3. Thorax, 80(2), 63-64. https://doi.org/10.1136/thorax-2024-221976

Background With higher valency pneumococcal vaccines on the horizon and new adult immunisation strategies under discussion, we aimed to evaluate the contribution of individual pneumococcal serotypes to the burden of pneumococcal community-acquired pn... Read More about Pneumococcal pneumonia trends in adults hospitalised with community-acquired pneumonia over 10 years (2013-2023) and the role of serotype 3.

Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia (2024)
Journal Article
Lansbury, L., McKeever, T. M., Lawrence, H., Pick, H., Baskaran, V., Edwards-Pritchard, R. C., Ashton, D., Rodrigo, C., Daniel, P., Litt, D., Eletu, S., Parmar, H., Sheppard, C. L., Ladhani, S., Trotter, C., & Lim, W. S. (2024). Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia. Journal of Infection, 89(5), Article 106277. https://doi.org/10.1016/j.jinf.2024.106277

Objectives

We aimed to determine the prevalence of and risk factors for nasopharyngeal and oral pneumococcal carriage in adults with community-acquired pneumonia (CAP), and the relationship between carried and disease-causing serotypes.

Methods... Read More about Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia.

Pneumococcal serotypes and risk factors in adult community-acquired pneumonia 2018–20; a multicentre UK cohort study (2023)
Journal Article
Lansbury, L., Lawrence, H., McKeever, T. M., French, N., Aston, S., Hill, A. T., Pick, H., Baskaran, V., Edwards-Pritchard, R. C., Bendall, L., Ashton, D., Butler, J., Daniel, P., Bewick, T., Rodrigo, C., Litt, D., Eletu, S., Sheppard, C. L., Fry, N. K., Ladhani, S., …Lim, W. S. (2024). Pneumococcal serotypes and risk factors in adult community-acquired pneumonia 2018–20; a multicentre UK cohort study. Lancet Regional Health – Europe, 37, Article 100812. https://doi.org/10.1016/j.lanepe.2023.100812

Background: Higher-valency pneumococcal vaccines are anticipated. We aimed to describe serotype distribution and risk factors for vaccine-serotype community-acquired pneumonia (CAP) in the two years pre-SARS-CoV-2 pandemic. Methods: We conducted a pr... Read More about Pneumococcal serotypes and risk factors in adult community-acquired pneumonia 2018–20; a multicentre UK cohort study.

Predicting outcome in acute respiratory admissions using patterns of National Early Warning Scores (2022)
Journal Article
Forster, S., McKeever, T. M., Churpek, M., Gonem, S., & Shaw, D. (2022). Predicting outcome in acute respiratory admissions using patterns of National Early Warning Scores. Clinical Medicine, 22(5), 409-415. https://doi.org/10.7861/clinmed.2022-0074

Aims Accurately predicting risk of patient deterioration is vital. Altered physiology in chronic disease affects the prognostic ability of vital signs based early warning score systems. We aimed to assess the potential of early warning score patterns... Read More about Predicting outcome in acute respiratory admissions using patterns of National Early Warning Scores.

Impact of Coexisting Dementia on Inpatient Outcomes for Patients Admitted with a COPD Exacerbation (2022)
Journal Article
Gupta, A., McKeever, T. M., Hutchinson, J. P., & Bolton, C. E. (2022). Impact of Coexisting Dementia on Inpatient Outcomes for Patients Admitted with a COPD Exacerbation. International Journal of Chronic Obstructive Pulmonary Disease, 2022(17), 535-544. https://doi.org/10.2147/copd.s345751

Purpose: People with COPD are at a higher risk of cognitive dysfunction than the general population. However, the additional impact of dementia amongst such patients is not well understood, particularly in those admitted with a COPD exacerbation. We... Read More about Impact of Coexisting Dementia on Inpatient Outcomes for Patients Admitted with a COPD Exacerbation.

Risk of subtrochanteric and femoral shaft fractures due to bisphosphonate therapy in asthma: a population-based nested case–control study (2021)
Journal Article
Chalitsios, C. V., Shaw, D. E., & McKeever, T. M. (2021). Risk of subtrochanteric and femoral shaft fractures due to bisphosphonate therapy in asthma: a population-based nested case–control study. Osteoporosis International, https://doi.org/10.1007/s00198-021-06197-7

Summary: Concerns have been raised over the association between bisphosphonates and atypical fractures in subtrochanteric and femoral shaft regions, but the potential risk of these fractures due to bisphosphonate use in asthma has not been examined.... Read More about Risk of subtrochanteric and femoral shaft fractures due to bisphosphonate therapy in asthma: a population-based nested case–control study.

Co-infection in critically ill patients with COVID-19: an observational cohort study from England (2021)
Journal Article
Baskaran, V., Lawrence, H., Lansbury, L., Webb, K., Safavi, S., Zainuddin, I., Huq, T., Eggleston, C., Ellis, J., Thakker, C., Charles, B., Boyd, S., Williams, T., Phillips, C., Redmore, E., Platt, S., Hamilton, E., Barr, A., Venyo, L., Wilson, P., …Shen Lim, W. (2021). Co-infection in critically ill patients with COVID-19: an observational cohort study from England. Journal of Medical Microbiology, 70(4), Article 001350. https://doi.org/10.1099/jmm.0.001350

Introduction: During previous viral pandemics, reported co-infection rates and implicated pathogens have varied. In the 1918 influenza pandemic, a large proportion of severe illness and death was complicated by bacterial co-infection, predominantly S... Read More about Co-infection in critically ill patients with COVID-19: an observational cohort study from England.

The feasibility and tolerability of using Inspiratory Muscle Training (IMT) with adults discharged from the hospital with community-acquired pneumonia (CAP) (2021)
Journal Article
Pick, H., Faghy, M., Cresswell, G., Ashton, D., Bolton, C., McKeever, T., Lim, W., & Bewick, T. (2021). The feasibility and tolerability of using Inspiratory Muscle Training (IMT) with adults discharged from the hospital with community-acquired pneumonia (CAP). Advances in Respiratory Medicine, 89, 216-220. https://doi.org/10.5603/ARM.a2021.0002

Background: Patients experience substantial morbidity following discharge from hospital and during recovery from community-acquired pneumonia (CAP). Inspiratory muscle training (IMT) has demonstrated improved functional capacity and reduced patient-r... Read More about The feasibility and tolerability of using Inspiratory Muscle Training (IMT) with adults discharged from the hospital with community-acquired pneumonia (CAP).

Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study (2020)
Journal Article
Siraj, R., McKeever, T., Gibson, J., Gordon, A., & Bolton, C. (2021). Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study. Respiratory Medicine, 177, Article 106288. https://doi.org/10.1016/j.rmed.2020.106288

Background: Although cognitive impairment and dementia are common comorbidities in patients with chronic obstructive pulmonary disease (COPD), estimates of incidence following a diagnosis of COPD are inconclusive. Objective: To determine the incidenc... Read More about Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study.

Incidence of osteoporosis and fragility fractures in asthma: a UK population-based matched cohort study (2020)
Journal Article
Chalitsios, C. V., McKeever, T. M., & Shaw, D. E. (2020). Incidence of osteoporosis and fragility fractures in asthma: a UK population-based matched cohort study. European Respiratory Journal, 56(Suppl. 64), Article 1427. https://doi.org/10.1183/13993003.congress-2020.1427

Background: Osteoporosis and fragility fractures (FF) are associated with corticosteroids which are the mainstay treatment for asthma; however, these bone comorbidities within asthma need to be better described.

Methods: A matched cohort study was... Read More about Incidence of osteoporosis and fragility fractures in asthma: a UK population-based matched cohort study.

Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against vaccine serotype pneumococcal pneumonia in adults: a case-control test-negative design study (2020)
Journal Article
Lawrence, H., Pick, H., Baskaran, V., Daniel, P., Rodrigo, C., Ashton, D., Edwards-Pritchard, R. C., Sheppard, C., Eletu, S. D., Litt, D., Fry, N. K., Rose, S., Trotter, C., McKeever, T. M., & Lim, W. S. (2020). Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against vaccine serotype pneumococcal pneumonia in adults: a case-control test-negative design study. PLoS Medicine, 17(10), Article e1003326. https://doi.org/10.1371/journal.pmed.1003326

Background: Vaccination with the 23-valent pneumococcal polysaccharide vaccine (PPV23) is available in the UK to adults aged 65 years or over and those in defined clinical risk groups. We evaluated the vaccine effectiveness (VE) of PPV23 against vac... Read More about Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against vaccine serotype pneumococcal pneumonia in adults: a case-control test-negative design study.

Risk of osteoporosis and fragility fractures in asthma due to oral and inhaled corticosteroids: two population-based nested case-control studies (2020)
Journal Article
Chalitsios, C. V., Shaw, D. E., & McKeever, T. M. (2020). Risk of osteoporosis and fragility fractures in asthma due to oral and inhaled corticosteroids: two population-based nested case-control studies. Thorax, 76(1), 21-28. https://doi.org/10.1136/thoraxjnl-2020-215664

© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. Background Inhaled (ICS) and oral (OCS) corticosteroids are used widely in asthma; however, the risk of osteoporosis and fragility fracture (... Read More about Risk of osteoporosis and fragility fractures in asthma due to oral and inhaled corticosteroids: two population-based nested case-control studies.

Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement (2020)
Journal Article
Gupta, A., Jayes, L. R., Holmes, S., Sahota, O., Canavan, M., Elkin, S. L., Lim, K., Murphy, A. C., Singh, S., Towlson, E. A., Ward, H., Scullion, J., McKeever, T. M., & Bolton, C. E. (2020). Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement. International Journal of Chronic Obstructive Pulmonary Disease, 15, 1377-1390. https://doi.org/10.2147/copd.s233398

Introduction: Osteoporosis and bone fractures are common in chronic obstructive pulmonary disease (COPD) and contribute significantly to morbidity and mortality. Current national guidance on COPD management recommends addressing bone health in patien... Read More about Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement.

Phenotypic and functional translation of IL33 genetics in asthma (2020)
Journal Article
Ketelaar, M. E., Portelli, M. A., Dijk, F. N., Shrine, N., Faiz, A., Vermeulen, C. J., Xu, C. J., Hankinson, J., Bhaker, S., Henry, A. P., Billington, C. K., Shaw, D. E., Johnson, S. R., Benest, A., Pang, V., Bates, D. O., Pogson, Z. E., Fogarty, A., McKeever, T. M., Singapuri, A., …Nawijn, M. C. (2021). Phenotypic and functional translation of IL33 genetics in asthma. Journal of Allergy and Clinical Immunology, 147(1), 144-157. https://doi.org/10.1016/j.jaci.2020.04.051

© 2020 Background: Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have been reproducibly associated with asthma. IL33 levels are elevate... Read More about Phenotypic and functional translation of IL33 genetics in asthma.

Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium (2020)
Journal Article
Portelli, M. A., Dijk, F. N., Ketelaar, M. E., Shrine, N., Hankinson, J., Bhaker, S., Grotenboer, N. S., Obeidat, M., Henry, A. P., Billington, C. K., Shaw, D., Johnson, S. R., Pogson, Z. E., Fogarty, A., McKeever, T. M., Nickle, D. C., Bossé, Y., van den Berge, M., Faiz, A., Brouwer, S., …Sayers, I. (2020). Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI insight, 5(8), Article 132446. https://doi.org/10.1172/jci.insight.132446

The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying these associations remain to be def... Read More about Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.

A retrospective database study of oral corticosteroid and bisphosphonate prescribing patterns in England (2020)
Journal Article
Chalitsios, C. V., Shaw, D. E., & McKeever, T. M. (2020). A retrospective database study of oral corticosteroid and bisphosphonate prescribing patterns in England. npj Primary Care Respiratory Medicine, 30(1), Article 5. https://doi.org/10.1038/s41533-020-0162-6

© 2020, The Author(s). Exposure to oral corticosteroids (OCS) is associated with an increased risk of osteoporosis and fragility fractures. Guidelines suggest bisphosphonate (BP) therapy as the first-line treatment of glucocorticoid-induced osteoporo... Read More about A retrospective database study of oral corticosteroid and bisphosphonate prescribing patterns in England.

The Its Not JUST Idiopathic pulmonary fibrosis Study (INJUSTIS): Description of the protocol for a multicentre prospective observational cohort study identifying biomarkers of progressive fibrotic lung disease (2019)
Journal Article
Khan, F., Stewart, I., Howard, L., McKeever, T., Jones, S., Hearson, G., Braybrooke, R., Edwards, C., Jenkins, G., & Saini, G. (2019). The Its Not JUST Idiopathic pulmonary fibrosis Study (INJUSTIS): Description of the protocol for a multicentre prospective observational cohort study identifying biomarkers of progressive fibrotic lung disease. BMJ Open Respiratory Research, 6(1), 1-7. https://doi.org/10.1136/bmjresp-2019-000439

Introduction: The Its Not JUST Idiopathic pulmonary fibrosis Study (INJUSTIS) is a multicentre, prospective, observational cohort study. The aims of this study are to identify genetic, serum and other biomarkers that may identify specific molecular m... Read More about The Its Not JUST Idiopathic pulmonary fibrosis Study (INJUSTIS): Description of the protocol for a multicentre prospective observational cohort study identifying biomarkers of progressive fibrotic lung disease.

Patient reported distress can aid clinical decision making in idiopathic pulmonary fibrosis: analysis of the PROFILE cohort (2019)
Journal Article
Stewart, I., McKeever, T., Braybrooke, R., Oballa, E., Simpson, J. K., Maher, T. M., Marshall, R. P., Lukey, P. T., Fahy, W. A., Jenkins, G., & Saini, G. (2019). Patient reported distress can aid clinical decision making in idiopathic pulmonary fibrosis: analysis of the PROFILE cohort. European Respiratory Journal, 53(5), Article 1801925. https://doi.org/10.1183/13993003.01925-2018

Idiopathic pulmonary fibrosis is a progressive and fatal interstitial lung disease. We aimed to determine if patient response to a palliative assessment survey could predict disease progression or death.

We undertook a cross-sectional study in a U... Read More about Patient reported distress can aid clinical decision making in idiopathic pulmonary fibrosis: analysis of the PROFILE cohort.

Patient reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review (2019)
Journal Article
Pick, H. J., Bolton, C. E., Lim, W. S., & McKeever, T. M. (2019). Patient reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review. European Respiratory Journal, 53(3), Article 1802165. https://doi.org/10.1183/13993003.02165-2018

Symptomatic and functional recovery are important patient-reported outcome measures (PROMs) in community-acquired pneumonia (CAP) that are increasingly used as trial endpoints. This systematic review summarises the literature on PROMs in CAP.

Comp... Read More about Patient reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review.