Genetic variants in glutamate-, A??, and tau-related pathways determine polygenic risk for Alzheimer's disease
(2020)
Journal Article
Lawingco, T., Chaudhury, S., Brookes, K. J., Guetta-Baranes, T., Guerreiro, R., Bras, J., …Morgan, K. (2021). Genetic variants in glutamate-, Aβ−, and tau-related pathways determine polygenic risk for Alzheimer's disease. Neurobiology of Aging, 101, 299.e13-299.e21. https://doi.org/10.1016/j.neurobiolaging.2020.11.009
© 2020 Elsevier Inc. Synapse loss is an early event in late-onset Alzheimer's disease (LOAD). In this study, we have assessed the capacity of a polygenic risk score (PRS) restricted to synapse-encoding loci to predict LOAD. We used summary statistics... Read More about Genetic variants in glutamate-, A??, and tau-related pathways determine polygenic risk for Alzheimer's disease.