All Outputs (2)

Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates features of early gliomagenesis (2016)
Journal Article
Bardella, C., Al-Dalahmah, O., Krell, D., Brazauskas, P., Al-Qahtani, K., Tomkova, M., Adam, J., Serres, S., Lockstone, H., Freeman-Mills, L., Pfeffer, I., Sibson, N., Goldin, R., Schuster-Böeckler, B., Pollard, P. J., Soga, T., McCullagh, J. S., Schofield, C. J., Mulholland, P., Ansorge, O., …Tomlinson, I. (2016). Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates features of early gliomagenesis. Cancer Cell, 30(4), 578-594. https://doi.org/10.1016/j.ccell.2016.08.017

Isocitrate dehydrogenase 1 mutations drive human gliomagenesis, probably through neomorphic enzyme activity that produces D-2-hydroxyglutarate. To model this disease, we conditionally expressed Idh1R132H in the subventricular zone (SVZ) of the adult... Read More about Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates features of early gliomagenesis.

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development (2016)
Journal Article
Raducu, M., Fung, E., Serres, S., Infante, P., Barberis, A., Fischer, R., Bristow, C., Thézénas, M., Finta, C., Christianson, J. C., Buffa, F. M., Kessler, B. M., Sibson, N. R., Di Marcotullio, L., Toftgård, R., & D'Angiolella, V. (2016). SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. EMBO Journal, 35(13), 1400-1416. https://doi.org/10.15252/embj.201593374

Skp1‐Cul1‐F‐box protein (SCF) ubiquitin ligases direct cell survival decisions by controlling protein ubiquitylation and degradation. Sufu (Suppressor of fused) is a central regulator of Hh (Hedgehog) signaling and acts as a tumor suppressor by maint... Read More about SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.