All Outputs (6)

Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men (2022)
Journal Article
Abdulla, H., Phillips, B., Wilkinson, D., Gates, A., Limb, M., Jandova, T., …Atherton, P. (2023). Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men. Journal of Clinical Endocrinology and Metabolism, 108(4), 971-978. https://doi.org/10.1210/clinem/dgac613

Introduction Ageing skeletal muscles become both insulin resistant and atrophic. The hormone glucagon-like peptide 1 (GLP-1) facilitates postprandial glucose uptake as well as augmenting muscle perfusion, independent of insulin action. We thus hypot... Read More about Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men.

Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men (2022)
Journal Article
Sayda, M. H., Abdul-Aziz, M. H., Gharahdaghi, N., Wilkinson, D. J., Greenhaff, P. L., Philips, B. E., …Atherton, P. J. (2022). Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men. Scientific Reports, 12, Article 19273. https://doi.org/10.1038/s41598-022-21814-z

Higher plasma leucine, isoleucine and valine (BCAA) concentrations are associated with diabetes, obesity and insulin resistance (IR). Here, we evaluated the effects of 6-weeks very-low calorie diet (VLCD) upon fasting BCAA in overweight (OW) non-diab... Read More about Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men.

Motor unit dysregulation following 15 days of unilateral lower limb immobilisation (2022)
Journal Article
Inns, T. B., Bass, J. J., Hardy, E. J., Wilkinson, D. J., Stashuk, D. W., Atherton, P. J., …Piasecki, M. (2022). Motor unit dysregulation following 15 days of unilateral lower limb immobilisation. Journal of Physiology, 600(21), 4753-4769. https://doi.org/10.1113/jp283425

Abstract: Disuse atrophy, caused by situations of unloading such as limb immobilisation, causes a rapid yet diverging reduction in skeletal muscle function when compared to muscle mass. While mechanistic insight into the loss of mass is well studied,... Read More about Motor unit dysregulation following 15 days of unilateral lower limb immobilisation.

The Association between Circulating Branched Chain Amino Acids and the Temporal Risk of Developing Type 2 Diabetes Mellitus: A Systematic Review & Meta-Analysis (2022)
Journal Article
Ramzan, I., Ardavani, A., Vanweert, F., Mellett, A., Atherton, P. J., & Idris, I. (2022). The Association between Circulating Branched Chain Amino Acids and the Temporal Risk of Developing Type 2 Diabetes Mellitus: A Systematic Review & Meta-Analysis. Nutrients, 14(20), Article 4411. https://doi.org/10.3390/nu14204411

Introduction: Recent studies have concluded that elevated circulating branched chain amino acids (BCAA) are associated with the pathogenesis of type 2 diabetes mellitus (T2DM) and obesity. However, the development of this association over time and th... Read More about The Association between Circulating Branched Chain Amino Acids and the Temporal Risk of Developing Type 2 Diabetes Mellitus: A Systematic Review & Meta-Analysis.

The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism (2022)
Journal Article
Jaconelli, M., Greenhaff, P. L., Atherton, P. J., Lobo, D. N., & Brook, M. S. (2022). The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism. Clinical Nutrition, 41(3), 709-722. https://doi.org/10.1016/j.clnu.2022.01.023

Background & aims Elective surgery induces skeletal muscle wasting driven by an imbalance between muscle protein synthesis and breakdown. From examination of diverse stable isotope tracer techniques, the dynamic processes driving this imbalance ar... Read More about The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism.

Neuromuscular recruitment strategies of the vastus lateralis according to sex (2022)
Journal Article
Guo, Y., Jones, E. J., Inns, T. B., Ely, I. A., Stashuk, D. W., Wilkinson, D. J., …Piasecki, M. (2022). Neuromuscular recruitment strategies of the vastus lateralis according to sex. Acta Physiologica, 235(2), Article e13803. https://doi.org/10.1111/apha.13803

Aim: Despite males typically exhibiting greater muscle strength and fatigability than females, it remains unclear if there are sex-based differences in neuromuscular recruitment strategies e.g. recruitment and modulation of motor unit firing rate (MU... Read More about Neuromuscular recruitment strategies of the vastus lateralis according to sex.