All Outputs (27)

Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents (2021)
Journal Article
Ottino-González, J., Albaugh, M. D., Cao, Z., Cupertino, R. B., Schwab, N., Spechler, P. A., …Garavan, H. (2022). Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents. Addiction, 117(5), 1312-1325. https://doi.org/10.1111/add.15772

BACKGROUND AND AIMS: Graph theoretic analysis of structural covariance networks (SCN) provides an assessment of brain organization that has not yet been applied to alcohol dependence (AD). We estimated whether SCN differences are present in adults wi... Read More about Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents.

Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study (2021)
Journal Article
Alyami, A., Hoad, C. L., Tench, C., Bannur, U., Clarke, C., Latief, K., …Moran, G. W. (2021). Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study. Diagnostics, 11(11), Article 2135. https://doi.org/10.3390/diagnostics11112135

Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potentia... Read More about Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study.

Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies (2021)
Journal Article
Dellschaft, N., Hoad, C., Marciani, L., Gowland, P., & Spiller, R. (2022). Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies. Alimentary Pharmacology and Therapeutics, 55(3), 327-338. https://doi.org/10.1111/apt.16673

Background: New developments in MRI have allowed the non-invasive, accurate measurement of the small bowel water content (SBWC). Aims: To collate studies measuring SBWC following ingestion of a range of foods in both health and disease to provide dat... Read More about Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies.

Global urbanicity is associated with brain and behaviour in young people (2021)
Journal Article
Xu, J., Liu, X., Li, Q., Goldblatt, R., Qin, W., Liu, F., …Schumann, G. (2022). Global urbanicity is associated with brain and behaviour in young people. Nature Human Behaviour, 6(2), 279-293. https://doi.org/10.1038/s41562-021-01204-7

Urbanicity is a growing environmental challenge for mental health. Here, we investigate correlations of urbanicity with brain structure and function, neuropsychology and mental illness symptoms in young people from China and Europe (total n = 3,867).... Read More about Global urbanicity is associated with brain and behaviour in young people.

Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation (2021)
Journal Article
Al-Awadi, A., Grove, J., Taylor, M., Valdes, A., Vijay, A., Bawden, S., …Aithal, G. (2021). Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation. BMJ Open, 11(10), Article e045802. https://doi.org/10.1136/bmjopen-2020-045802

Introduction A Low Glycaemic Index (LGI) diet is a proposed lifestyle intervention in non-alcoholic fatty liver diseases (NAFLD) which is designed to reduce circulating blood glucose levels, hepatic glucose influx, insulin resistance and de novo lipo... Read More about Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation.

Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model (2021)
Journal Article
Penninck, L., Ibrahim, E. C., Artiges, E., Gorgievski, V., Desrivières, S., Farley, S., …Martinot, J. (2021). Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model. Frontiers in Systems Neuroscience, 15, 1-14. https://doi.org/10.3389/fnsys.2021.725413

Adolescence is a period of vulnerability for the maturation of gray matter (GM) and also for the onset of psychiatric disorders such as major depressive disorder (MDD), bipolar disorder and schizophrenia. Chronic neuroinflammation is considered to pl... Read More about Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model.

Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation (2021)
Journal Article
Elkrief, L., Lin, B., Marchi, M., Afzali, M. H., Banaschewski, T., Bokde, A. L. W., …Consortium, I. (2023). Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation. Psychological Medicine, 53(5), 1759-1769. https://doi.org/10.1017/s0033291721003378

Background It has not yet been determined if the commonly reported cannabis–psychosis association is limited to individuals with pre-existing genetic risk for psychotic disorders. Methods We examined whether the relationship between polygenic ri... Read More about Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation.

Similarity and stability of face network across populations and throughout adolescence and adulthood (2021)
Journal Article
Liao, Z., Banaschewski, T., Bokde, A. L. W., Desrivières, S., Flor, H., Grigis, A., …Paus, T. (2021). Similarity and stability of face network across populations and throughout adolescence and adulthood. NeuroImage, 244, Article 118587. https://doi.org/10.1016/j.neuroimage.2021.118587

The ability to extract cues from faces is fundamental for social animals, including humans. An individual's profile of functional connectivity across a face network can be shaped by common organizing principles, stable individual traits, and time-var... Read More about Similarity and stability of face network across populations and throughout adolescence and adulthood.

Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients (2021)
Journal Article
Jewell, A., Williams, H., Hoad, C. L., Gellert, P. R., Ashford, M. B., Butler, J., …Gershkovich, P. (2021). Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients. Pharmaceutics, 13(9), Article 1343. https://doi.org/10.3390/pharmaceutics13091343

Dietary lipids and some pharmaceutical lipid excipients can facilitate the targeted delivery of drugs to the intestinal lymphatics. Here, the feasibility of magnetic resonance imaging (MRI) for imaging lipid uptake into the intestinal lymphatics was... Read More about Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients.

Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies (2021)
Journal Article
Gunn, D., Abbas, Z., Harris, H., Major, G., Hoad, C., Gowland, P., …Spiller, R. (2022). Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies. Gut, 71(5), 919-927. https://doi.org/10.1136/gutjnl-2021-324784

Objective: Health promoting dietary fibre including inulin often triggers gastrointestinal symptoms in patients with irritable bowel syndrome (IBS), limiting their intake. Our aim was to test if co-administering psyllium with inulin would reduce gas... Read More about Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies.

Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging (2021)
Journal Article
Ng, C., Dellschaft, N. S., Hoad, C. L., Marciani, L., Ban, L., Prayle, A. P., …Smyth, A. R. (2021). Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging. Journal of Cystic Fibrosis, 20(4), 591-597. https://doi.org/10.1016/j.jcf.2020.06.004

Background: Cystic fibrosis (CF) is a multi-system genetic disorder affecting >72,000 people worldwide. Most CF patients experience gastrointestinal symptoms and can develop complications. However, the mechanisms of CF gut disease are not well unders... Read More about Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging.

Association of Cannabis Use During Adolescence With Neurodevelopment (2021)
Journal Article
Albaugh, M. D., Ottino-Gonzalez, J., Sidwell, A., Lepage, C., Juliano, A., Owens, M. M., …Garavan, H. (2021). Association of Cannabis Use During Adolescence With Neurodevelopment. JAMA Psychiatry, 78(9), 1031-1040. https://doi.org/10.1001/jamapsychiatry.2021.1258

IMPORTANCE Animal studies have shown that the adolescent brain is sensitive to disruptions in endocannabinoid signaling, resulting in altered neurodevelopment and lasting behavioral effects. However, few studies have investigated ties between cannabi... Read More about Association of Cannabis Use During Adolescence With Neurodevelopment.

Residual effects of cannabis-use on neuropsychological functioning (2021)
Journal Article
Wendel, L. K., Daedelow, L., Kaminski, J., Banaschewski, T., Millenet, S., Bokde, A. L., …Walter, H. (2021). Residual effects of cannabis-use on neuropsychological functioning. Cognitive Development, 59, Article 101072. https://doi.org/10.1016/j.cogdev.2021.101072

Non-acute effects of cannabis on neurocognition in adolescents remain unclear with most studies being cross-sectional. Therefore, the aim of this longitudinal, multi-center study was to examine the effects of cannabis use on cognitive abilities in pa... Read More about Residual effects of cannabis-use on neuropsychological functioning.

Test–retest assessment of non-contrast MRI sequences to characterise and quantify the small bowel wall in healthy participants (2021)
Journal Article
Alyami, A. S., Williams, H. G., Argyriou, K., Gunn, D., Wilkinson-Smith, V., White, J. R., …Hoad, C. L. (2021). Test–retest assessment of non-contrast MRI sequences to characterise and quantify the small bowel wall in healthy participants. Magnetic Resonance Materials in Physics, Biology and Medicine, 34, 791-804. https://doi.org/10.1007/s10334-021-00931-2

Objective: Quantitative Magnetic Resonance Imaging sequences have been investigated as objective imaging biomarkers of fibrosis and inflammation in Crohn’s disease. Aim: To determine the repeatability and inter- and intra-observer agreement of these... Read More about Test–retest assessment of non-contrast MRI sequences to characterise and quantify the small bowel wall in healthy participants.

Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI (2021)
Journal Article
Sharif, H., Hoad, C. L., Abrehart, N., Gowland, P. A., Spiller, R. C., Kirkham, S., …Marciani, L. (2021). Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI. Diagnostics, 11(6), Article 974. https://doi.org/10.3390/diagnostics11060974

Background: Functional constipation in children is common. Management of this condition can be challenging and is often based on symptom reports. Increased, objective knowledge of colonic volume changes in constipation compared to health could provid... Read More about Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI.

Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect (2021)
Journal Article
Böttinger, B. W., Baumeister, S., Millenet, S., Barker, G. J., Bokde, A. L. W., Büchel, C., …IMAGEN Consortium. (2021). Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect. European Child and Adolescent Psychiatry, https://doi.org/10.1007/s00787-021-01770-1

Conduct problems (CP) in patients with disruptive behavior disorders have been linked to impaired prefrontal processing of negative facial affect compared to controls. However, it is unknown whether associations with prefrontal activity during affect... Read More about Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect.

Endocannabinoid Gene x Gene Interaction Association to Alcohol Use Disorder in two Adolescent Cohorts (2021)
Journal Article
Elkrief, L., Spinney, S., Vosberg, D. E., Banaschewski, T., Bokde, A., Quinlan, E. B., …Conrod, P. (2021). Endocannabinoid Gene x Gene Interaction Association to Alcohol Use Disorder in two Adolescent Cohorts. Frontiers in Psychiatry, 12, Article 645746. https://doi.org/10.3389/fpsyt.2021.645746

Genetic markers of endocannabinoid system have been linked to a variety of addiction-related behaviours that extend beyond cannabis use. In the current study we investigate the relationship between eCB genetic markers and AUDs in European adolescents... Read More about Endocannabinoid Gene x Gene Interaction Association to Alcohol Use Disorder in two Adolescent Cohorts.

Sex differences in neural correlates of common psychopathological symptoms in early adolescence (2021)
Journal Article
Biondo, F., Thunell, C. N., Xu, B., Chu, C., Jia, T., Ing, A., …IMAGEN Consortium. (2022). Sex differences in neural correlates of common psychopathological symptoms in early adolescence. Psychological Medicine, 52(14), 3086-3096. https://doi.org/10.1017/S0033291720005140

Background Sex-related differences in psychopathology are known phenomena, with externalizing and internalizing symptoms typically more common in boys and girls, respectively. However, the neural correlates of these sex-by-psychopathology interaction... Read More about Sex differences in neural correlates of common psychopathological symptoms in early adolescence.

Calibration-free regional RF shims for MRS (2021)
Journal Article
Berrington, A., Považan, M., Mirfin, C., Bawden, S., Park, Y. W., Marsh, D. C., …Gowland, P. A. (2021). Calibration-free regional RF shims for MRS. Magnetic Resonance in Medicine, 86(2), 611-624. https://doi.org/10.1002/mrm.28749

Purpose: Achieving a desired RF transmit field (B1+) in small regions-of-interest (ROIs) is critical for single-voxel MR spectroscopy at ultra-high field. RF shimming, using parallel transmission, requires B1+ mapping and optimisation, which limits i... Read More about Calibration-free regional RF shims for MRS.

Predicting Depression Onset in Young People Based on Clinical, Cognitive, Environmental, and Neurobiological Data (2021)
Journal Article
Toenders, Y. J., Kottaram, A., Dinga, R., Davey, C. G., Banaschewski, T., Bokde, A. L., …Schmaal, L. (2022). Predicting Depression Onset in Young People Based on Clinical, Cognitive, Environmental, and Neurobiological Data. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7(4), 376-384. https://doi.org/10.1016/j.bpsc.2021.03.005

Background Adolescent onset of depression is associated with long-lasting negative consequences. Identifying adolescents at risk for developing depression would enable the monitoring of risk-factors and the development of early intervention strategi... Read More about Predicting Depression Onset in Young People Based on Clinical, Cognitive, Environmental, and Neurobiological Data.