All Outputs (26)

Enabling the Scale-Up of a Key Asymmetric Hydrogenation Step in the Synthesis of an API Using Continuous Flow Solid-Supported Catalysis (2016)
Journal Article
Amara, Z., Poliakoff, M., Duque, R., Geier, D., Franciò, G., Gordon, C. M., Meadows, R. E., Woodward, R., & Leitner, W. (2016). Enabling the Scale-Up of a Key Asymmetric Hydrogenation Step in the Synthesis of an API Using Continuous Flow Solid-Supported Catalysis. Organic Process Research and Development, 20(7), 1321-1327. https://doi.org/10.1021/acs.oprd.6b00143

© 2016 American Chemical Society. The development of a continuous flow process for asymmetric hydrogenation with a heterogenized molecular catalyst in a real industrial context is reported. The key asymmetric step in the synthesis of an API (active p... Read More about Enabling the Scale-Up of a Key Asymmetric Hydrogenation Step in the Synthesis of an API Using Continuous Flow Solid-Supported Catalysis.

The twelve principles of CO2 Chemistry (2015)
Journal Article
Poliakoff, M., Leitner, W., & Streng, E. S. (2015). The twelve principles of CO2 Chemistry. Faraday Discussions, https://doi.org/10.1039/c5fd90078f

This paper introduces a set of 12 Principles, based on the acronym CO2 CHEMISTRY, which are intended to form a set of criteria for assessing the viability of different processes or reactions for using CO2 as a feedstock for making organic chemicals.... Read More about The twelve principles of CO2 Chemistry.

A synthetic-dynamic method for water solubility measurements in high pressure CO2 using ATR–FTIR spectroscopy (2015)
Journal Article
Comak, G., Foltran, S., Ke, J., Pérez, E., Sánchez-Vicente, Y., George, M. W., & Poliakoff, M. (2016). A synthetic-dynamic method for water solubility measurements in high pressure CO2 using ATR–FTIR spectroscopy. Journal of Chemical Thermodynamics, 93, https://doi.org/10.1016/j.jct.2015.09.024

A new synthetic method for studying phase behaviour is described using Attenuated Total Reflection (ATR) spectroscopy. The method has been developed to provide relevant information on the solubility of water in CO2. The dew point of water has been de... Read More about A synthetic-dynamic method for water solubility measurements in high pressure CO2 using ATR–FTIR spectroscopy.

Applying green chemistry to the photochemical route to artemisinin (2015)
Journal Article
Amara, Z., Bellamy, J. F. B., Horvath, R., Miller, S. J., Beeby, A., Burgard, A., Rossen, K., Poliakoff, M., & George, M. W. (2015). Applying green chemistry to the photochemical route to artemisinin. Nature Chemistry, 7(6), 489-495. https://doi.org/10.1038/nchem.2261

Artemisinin is an important antimalarial drug but, currently, the environmental and economic costs of its semi-synthetic production are relatively high. Most of these costs originate in the final chemical steps which follow a complex acid- and photo-... Read More about Applying green chemistry to the photochemical route to artemisinin.

Photocatalytic hydroxylation of arylboronic acids using continuous flow reactors (2014)
Journal Article
Penders, I. G. T. M., Amara, Z., Horvath, R., Rossen, K., Poliakoff, M., & George, M. W. (in press). Photocatalytic hydroxylation of arylboronic acids using continuous flow reactors. RSC Advances, 5(9), https://doi.org/10.1039/c4ra15588b

The photocatalytic oxidation of mono- and di-substituted arylboronic acids to phenols has been investigated using a continuous flow photoreactor fitted with white LEDs. An EtOH–H2O solvent system accelerated conversion at 2 MPa; whereas reactions at... Read More about Photocatalytic hydroxylation of arylboronic acids using continuous flow reactors.

Synthesis of metal-organic frameworks by continuous flow (2014)
Journal Article
Bayliss, P. A., Ibarra, I., Perez, E., Yang, S., Tang, C. C., Poliakoff, M., & Schröder, M. (2014). Synthesis of metal-organic frameworks by continuous flow. Green Chemistry, 16(8), https://doi.org/10.1039/C4GC00313F

A continuous flow process for the synthesis of a metal-organic framework using only water as the reaction medium and requiring only short residence times is described. This affords a new route to scale-up of materials incorporating many of the princi... Read More about Synthesis of metal-organic frameworks by continuous flow.