All Outputs (85)

Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers (2017)
Journal Article
Deloose, E., Janssen, P., Corsetti, M., Biesiekierski, J., Masuy, I., Rotondo, A., Van Oudenhove, L., Depoortere, I., & Tack, J. (2017). Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers. American Journal of Clinical Nutrition, 105(3), 580-588. https://doi.org/10.3945/ajcn.116.138297

Background: Denatonium benzoate (DB) has been shown to influence ongoing ingestive behavior and gut peptide secretion.
Objective: We studied how the intragastric administration of DB affects interdigestive motility, motilin and ghrelin plasma concen... Read More about Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers.

Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities (2016)
Journal Article
Hens, B., Corsetti, M., Spiller, R. C., Marciani, L., Vanuytsel, T., Tack, J., Talattof, A., Amidon, G. L., Koziolek, M., Weitschies, W., Wilson, C. G., Bennink, R. J., Brouwers, J., & Augustijns, P. (2017). Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities. International Journal of Pharmaceutics, 519(1-2), https://doi.org/10.1016/j.ijpharm.2016.11.063

Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables i... Read More about Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities.

Manometric evaluation of anorectal function in patients treated with neoadjuvant chemoradiotherapy and total mesorectal excision for rectal cancer (2016)
Journal Article
De Nardi, P., Testoni, S. G. G., Corsetti, M., Andreoletti, H., Giollo, P., Passarett, S., & Testoni, P. A. (2017). Manometric evaluation of anorectal function in patients treated with neoadjuvant chemoradiotherapy and total mesorectal excision for rectal cancer. Digestive Diseases and Sciences, 49(1), https://doi.org/10.1016/j.dld.2016.09.005

BACKGROUND: An altered anorectal function is reported after chemoradiotherapy (CRT) and surgery for rectal cancer.
AIM: The aim of this study was to clarify the relative contribution of neoadjuvant chemoradiation and surgical resection on the impair... Read More about Manometric evaluation of anorectal function in patients treated with neoadjuvant chemoradiotherapy and total mesorectal excision for rectal cancer.

Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry (2016)
Journal Article
Corsetti, M., Pagliaro, G., Demedts, I., Deloose, E., Gevers, A., Scheerens, C., Rommel, N., & Tack, J. (2017). Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry. American Journal of Gastroenterology, 112(3), https://doi.org/10.1038/ajg.2016.341

Background: Only few studies have applied high-resolution manometry (HRM) to the study of colonic motility in adults and none of them have concurrently evaluated colonic and anal motor activity. Aims: To evaluate colonic and anal motor activity by me... Read More about Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry.

Gastrointestinal and systemic monitoring of posaconazole in humans after fasted and fed state administration of a solid dispersion (2016)
Journal Article
Hens, B., Corsetti, M., Brouwers, J., & Augustijns, P. (2016). Gastrointestinal and systemic monitoring of posaconazole in humans after fasted and fed state administration of a solid dispersion. Journal of Pharmaceutical Sciences, 105(9), 2904-2912. https://doi.org/10.1016/j.xphs.2016.03.027

The purpose of this study was to explore the intraluminal behavior and systemic exposure of posaconazole in humans after oral intake of a novel delayed-release tablet (Noxafil®), containing posaconazole dispersed in a matrix of hydroxypropyl methylce... Read More about Gastrointestinal and systemic monitoring of posaconazole in humans after fasted and fed state administration of a solid dispersion.