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How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery) (2019)
Journal Article
Pauwels, A., Boecxstaens, V., Andrews, C., Attwood, S. E., Berrisford, R., Bisschops, R., Boeckxstaens, G., Bor, S., Bredenoord, A. J., Cicala, M., Corsetti, M., Fornari, F., Gyawali, C. P., Hatlebakk, J. G., Johnson, S. B., Lerut, T., Lundell, L., Mattioli, S., Miwa, H., Nafteux, P., …Tack, J. F. (2019). How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery). Gut, 68(11), 1928-1941. https://doi.org/10.1136/gutjnl-2019-318260

Objective: Anti-reflux surgery can be proposed in patients with gastro-esophageal reflux disease, especially when proton pump inhibitor use leads to incomplete symptom improvement. However, to date, international consensus guidelines on the clinical... Read More about How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery).

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques (2019)
Journal Article
Corsetti, M., Costa, M., Bassotti, G., Bharucha, A. E., Borrelli, O., Dinning, P., Lorenzo, C. D., Huizinga, J. D., Jimenez, M., Rao, S., Spiller, R., Spencer, N. J., Lentle, R., Pannemans, J., Thys, A., Benninga, M., & Tack, J. (2019). First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nature Reviews Gastroenterology and Hepatology, 16(9), 559-579. https://doi.org/10.1038/s41575-019-0167-1

Alterations in colonic motility are implicated in the pathophysiology of bowel disorders, but high-resolution manometry of human colonic motor function has revealed that our knowledge of normal motor patterns is limited. Furthermore, various terminol... Read More about First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.

“Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy (2019)
Journal Article
Hens, B., Corsetti, M., Bermejo, M., Löbenberg, R., González, P. M., Mitra, A., Desai, D., Chilukuri, D. M., & Aceituno, A. (2019). “Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy. AAPS Journal, 21(4), 1-16. https://doi.org/10.1208/s12248-019-0346-6

The gastrointestinal (GI) tract is one of the most popular and used routes of drug product administration due to the convenience for better patient compliance and reduced costs to the patient compared to other routes. However, its complex nature pose... Read More about “Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy.

Defecatory urge increases cognitive control and intertemporal patience in healthy volunteers (2019)
Journal Article
Zhao, D., Corsetti, M., Moeini-Jazani, M., Weltens, N., Tuk, M., Tack, J., Warlop, L., & Van Oudenhove, L. (2019). Defecatory urge increases cognitive control and intertemporal patience in healthy volunteers. Neurogastroenterology and Motility, 31(7), Article e13600. https://doi.org/10.1111/nmo.13600

Background: Past research has demonstrated that moderate urge to urinate improves inhibitory control, specifically among participants with higher behavioral inhibition sensitivity (BIS). The effect was absent when the urge exceeded intolerable level.... Read More about Defecatory urge increases cognitive control and intertemporal patience in healthy volunteers.

The mechanisms of pharmacokinetic food-drug interactions: A perspective from the UNGAP group (2019)
Journal Article
Koziolek, M., Alcaro, S., Augustijns, P., Basit, A. W., Grimm, M., Hens, B., Hoad, C. L., Jedamzik, P., Madla, C. M., Maliepaard, M., Marciani, L., Maruca, A., Parrott, N., Pávek, P., Porter, C. J., Reppas, C., van Riet-Nales, D., Rubbens, J., Statelova, M., Trevaskis, N. L., …Corsetti, M. (2019). The mechanisms of pharmacokinetic food-drug interactions: A perspective from the UNGAP group. European Journal of Pharmaceutical Sciences, 134, 31-59. https://doi.org/10.1016/j.ejps.2019.04.003

The simultaneous intake of food and drugs can have a strong impact on drug release, absorption, distribution, metabolism and/or elimination and consequently, on the efficacy and safety of pharmacotherapy. As such, food-drug interactions are one of th... Read More about The mechanisms of pharmacokinetic food-drug interactions: A perspective from the UNGAP group.

Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders? (2019)
Journal Article
Corsetti, M., Pannemans, J., & Whorwell, P. (2019). Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?. F1000Research, 8, Article 257. https://doi.org/10.12688/f1000research.15974.1

Opioids have recently received much attention because of the epidemic in their use in some countries such as the USA and the UK. Concerns have been raised about the possibility that they can increase mortality in patients when used on a long-term bas... Read More about Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?.

Prevalence and impact of self-reported irritable bowel symptoms in the general population (2018)
Journal Article
Van den Houte, K., Carbone, F., Pannemans, J., Corsetti, M., Fischler, B., Piessevaux, H., & Tack, J. (2019). Prevalence and impact of self-reported irritable bowel symptoms in the general population. United European Gastroenterology Journal, 7(2), 307-315. https://doi.org/10.1177/2050640618821804

Background and aims
The symptom-based diagnostic criteria for irritable bowel syndrome (IBS) have recently been revised in the Rome IV consensus. On the other hand, with rising public awareness of IBS, self-diagnosis and self-management is also incr... Read More about Prevalence and impact of self-reported irritable bowel symptoms in the general population.

Will MRI of gastrointestinal function parallel the clinical success of cine cardiac MRI? (2018)
Journal Article
Hoad, C., Clarke, C., Marciani, L., Graves, M. J., & Corsetti, M. (2018). Will MRI of gastrointestinal function parallel the clinical success of cine cardiac MRI?. British Journal of Radiology, 92(1093), https://doi.org/10.1259/bjr.20180433

Cine cardiac MRI is generally accepted as the “gold-standard” for functional myocardial assessment. It only took a few years after the development of commercial MRI systems for functional cardiac imaging to be developed, with electrocardiogram (ECG)-... Read More about Will MRI of gastrointestinal function parallel the clinical success of cine cardiac MRI?.

Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders? (2018)
Journal Article
Pannemans, J., & Corsetti, M. (2018). Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?. Current Opinion in Pharmacology, 43, 53-58. https://doi.org/10.1016/j.coph.2018.08.008

Opioids have been used for centuries, mostly as a sedative and to treat pain. Currently, they are used on a global scale for the treatment of acute and chronic pain in diseases as osteoarthritis, fibromyalgia, and low back pain. Binding of opioids on... Read More about Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?.

Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome (2018)
Journal Article
Barbara, G., Grover, M., Bercik, P., Corsetti, M., Ghoshal, U. C., Ohman, L., & Rajilić-Stojanović, M. (2019). Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome. Gastroenterology, 156(1), 46-58.e7. https://doi.org/10.1053/j.gastro.2018.07.011

Background & Aims: The existence of postinfection irritable bowel syndrome (PI-IBS) has been substantiated by epidemiology studies conducted in diverse geographic and clinical settings. However, the available evidence has not been well summarized, an... Read More about Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome.

When all seems lost: management of refractory constipation—Surgery, rectal irrigation, percutaneous endoscopic colostomy, and more (2018)
Journal Article
Wilkinson-Smith, V., Bharucha, A. E., Emmanuel, A., Knowles, C., Yiannakou, Y., & Corsetti, M. (2018). When all seems lost: management of refractory constipation—Surgery, rectal irrigation, percutaneous endoscopic colostomy, and more. Neurogastroenterology and Motility, 30(5), Article e13352. https://doi.org/10.1111/nmo.13352

© 2018 John Wiley & Sons Ltd While the pharmacological armamentarium for chronic constipation has expanded over the past few years, a substantial proportion of constipated patients do not respond to these medications. This review summarizes the pha... Read More about When all seems lost: management of refractory constipation—Surgery, rectal irrigation, percutaneous endoscopic colostomy, and more.

Development, content validity and cross-cultural adaptation of a Patient-Reported Outcome Measure for Real-time Symptom Assessment in Irritable Bowel Syndrome (2017)
Journal Article
Vork, L., Keszthely, D., Mujagic, Z., Kruimel, J., Leue, C., Pontén, I., Törnblom, H., Simren, M., Albu-Soda, A., Aziz, Q., Corsetti, M., Holvoet, L., Tack, J., Rao, S., van Os, J., Quetglas, E., Drossman, D., & Masclee, A. (in press). Development, content validity and cross-cultural adaptation of a Patient-Reported Outcome Measure for Real-time Symptom Assessment in Irritable Bowel Syndrome. Neurogastroenterology and Motility, 30(3), Article e13244. https://doi.org/10.1111/nmo.13244

BACKGROUND: End-of-day questionnaires, which are considered the gold standard for assessing abdominal pain and other gastrointestinal (GI) symptoms in irritable bowel syndrome (IBS), are influenced by recall and ecological bias. The Experience Sampli... Read More about Development, content validity and cross-cultural adaptation of a Patient-Reported Outcome Measure for Real-time Symptom Assessment in Irritable Bowel Syndrome.

The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature? (2017)
Journal Article
Corsetti, M., & Fox, M. (2017). The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature?. F1000Research, 6, Article 1778. https://doi.org/10.12688/f1000research.12089.1

© 2017 Corsetti M and Fox M. Functional dyspepsia is a prevalent functional gastrointestinal disorder that can significantly erode the quality of life of sufferers and places a major cost burden on healthcare services. In this article, we review the... Read More about The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature?.

Irritable bowel syndrome diagnosis and management: A simplified algorithm for clinical practice (2017)
Journal Article
Moayyedi, P., Mearin, F., Azpiroz, F., Andresen, V., Barbara, G., Corsetti, M., Emmanuel, A., Hungin, A. P. S., Layer, P., Stanghellini, V., Whorwell, P., Zerbib, F., & Tack, J. (2017). Irritable bowel syndrome diagnosis and management: A simplified algorithm for clinical practice. United European Gastroenterology Journal, 5(6), 773-788. https://doi.org/10.1177/2050640617731968

Plausibility criteria for putative pathophysiological mechanisms in functional gastrointestinal disorders: a consensus of experts (2017)
Journal Article
Tack, J., Corsetti, M., Camilleri, M., Quigley, A., Simren, M., Suzuki, H., Talley, N. J., Tornbloom, H., & Van Oudenhove, L. (in press). Plausibility criteria for putative pathophysiological mechanisms in functional gastrointestinal disorders: a consensus of experts. Gut, https://doi.org/10.1136/gutjnl-2016-312230

The functional gastrointestinal disorders (FGIDs), are extremely common conditions associated with a considerable personal, social and health economic burden. Managing FGIDs in clinical practice is challenging because of the uncertainty of symptom-ba... Read More about Plausibility criteria for putative pathophysiological mechanisms in functional gastrointestinal disorders: a consensus of experts.

Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in health female volunteers (2017)
Journal Article
Deloose, E., Corsetti, M., Van Oudenhove, L., Depoortere, I., & Tack, J. (2017). Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in health female volunteers. Neurogastroenterology and Motility, 30(1), Article e13171. https://doi.org/10.1111/nmo.13171

Intragastric administration of the bitter tastant denatonium benzoate inhibits the increase of motilin plasma levels and antral contractility. While these findings suggest that gastrointestinal bitter taste receptors could be new targets to modulate... Read More about Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in health female volunteers.

The global impact of IBS: time to think about IBS-specific models of care? (2017)
Journal Article
Corsetti, M., & Whorwell, P. (2017). The global impact of IBS: time to think about IBS-specific models of care?. Therapeutic Advances in Gastroenterology, 10(9), 727-736. https://doi.org/10.1177/1756283x17718677

Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal (GI) disorder that can significantly erode the quality of life (QoL) of sufferers and places a major cost burden on healthcare services. This paper reviews the literature on th... Read More about The global impact of IBS: time to think about IBS-specific models of care?.

New therapeutic options for IBS: the role of the first in class mixed µ- opioid receptor agonist and δ-opioid receptor antagonist (mudelta) eluxadoline (2017)
Journal Article
Corsetti, M., & Whorwell, P. (2017). New therapeutic options for IBS: the role of the first in class mixed µ- opioid receptor agonist and δ-opioid receptor antagonist (mudelta) eluxadoline. Expert Review of Gastroenterology and Hepatology, 11(4), 285-292. https://doi.org/10.1080/17474124.2017.1298442

Introduction: Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder which represents a major cost to healthcare services. IBS-D patients represent about one-third of the IBS population and are currently treated with antis... Read More about New therapeutic options for IBS: the role of the first in class mixed µ- opioid receptor agonist and δ-opioid receptor antagonist (mudelta) eluxadoline.