Cas1-Cas2 physically and functionally interacts with DnaK to modulate CRISPR Adaptation

Killelea, Tom; Dimude, Juachi U; He, Liu; Stewart, Alison L; Kemm, Fiona E; Radovčí, Marin; Ivančić-Baće, Ivana; Rudolph, Christian J; Bolt, Edward L

doi:10.1093/nar/gkad473

All Outputs (2)

The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution (2025)
Journal Article
Pan, J. M., Betts, H., Cubbon, A., Bolt, E. L., Soultanas, P., & He, L. (2025). The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution. Open Biology, 15(2), https://doi.org/10.1098/rsob.240112

The human HELQ helicase is a superfamily 2, 3’-5’ helicase homologous to POLQ and RNA helicases of the Ski2-like subfamily. It is involved in diverse aspects of DNA repair and is an emerging prognosis biomarker and novel drug-target for cancer therap... Read More about The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution.

Cas1-Cas2 physically and functionally interacts with DnaK to modulate CRISPR Adaptation (2023)
Journal Article
Killelea, T., Dimude, J. U., He, L., Stewart, A. L., Kemm, F. E., Radovčí, M., Ivančić-Baće, I., Rudolph, C. J., & Bolt, E. L. (2023). Cas1-Cas2 physically and functionally interacts with DnaK to modulate CRISPR Adaptation. Nucleic Acids Research, 51(13), 6914-6926. https://doi.org/10.1093/nar/gkad473

Prokaryotic Cas1-Cas2 protein complexes generate adaptive immunity to mobile genetic elements (MGEs), by capture and integration of MGE DNA in to CRISPR sites. De novo immunity relies on naive adaptation-Cas1-Cas2 targeting of MGE DNA without the aid... Read More about Cas1-Cas2 physically and functionally interacts with DnaK to modulate CRISPR Adaptation.