All Outputs (30)

On the combined effects of normobaric hypoxia and bed rest upon bone and mineral metabolism: Results from the PlanHab study (2016)
Journal Article
Rittweger, J., Debevec, T., Frings-Meuthen, P., Lau, P., Mittag, U., Ganse, B., …Mekjavic, I. B. (2016). On the combined effects of normobaric hypoxia and bed rest upon bone and mineral metabolism: Results from the PlanHab study. BONE, 91, 130-138. https://doi.org/10.1016/j.bone.2016.07.013

Bone losses are common as a consequence of unloading and also in patients with chronic obstructive pulmonary disease (COPD). Although hypoxia has been implicated as an important factor to drive bone loss, its interaction with unloading remains unreso... Read More about On the combined effects of normobaric hypoxia and bed rest upon bone and mineral metabolism: Results from the PlanHab study.

Effects of prolonged hypoxia and bed rest on appetite and appetite-related hormones (2016)
Journal Article
Debevec, T., Simpson, E. J., Mekjavic, I. B., Eiken, O., & Macdonald, I. A. (2016). Effects of prolonged hypoxia and bed rest on appetite and appetite-related hormones. Appetite, 107, 28-37. https://doi.org/10.1016/j.appet.2016.07.005

Environmental hypoxia and inactivity have both been shown to modulate appetite. To elucidate the independent and combined effects of hypoxia and bed rest-induced inactivity on appetite-related hormones and subjective appetite, eleven healthy, non-obe... Read More about Effects of prolonged hypoxia and bed rest on appetite and appetite-related hormones.

The Effect of Normobaric Hypoxic Confinement on Metabolism, Gut Hormones, and Body Composition (2016)
Journal Article
Mekjavic, I. B., Amon, M., Kölegård, R., Kounalakis, S. N., Simpson, L., Eiken, O., …Macdonald, I. A. (2016). The Effect of Normobaric Hypoxic Confinement on Metabolism, Gut Hormones, and Body Composition. Frontiers in Physiology, 7, Article 202. https://doi.org/10.3389/fphys.2016.00202

To assess the effect of normobaric hypoxia on metabolism, gut hormones, and body composition, 11 normal weight, aerobically trained (O2peak: 60.6 ± 9.5 ml·kg-1·min-1) men (73.0 ± 7.7 kg; 23.7 ± 4.0 years, BMI 22.2 ± 2.4 kg·m-2) were confined to a nor... Read More about The Effect of Normobaric Hypoxic Confinement on Metabolism, Gut Hormones, and Body Composition.

Orange juice consumption and its effect on blood lipid profile and indices of the metabolic syndrome; a randomised, controlled trial in an at-risk population (2016)
Journal Article
Simpson, E. J., Mendis, B., & MacDonald, I. A. (in press). Orange juice consumption and its effect on blood lipid profile and indices of the metabolic syndrome; a randomised, controlled trial in an at-risk population. Food and Function, 7(4), https://doi.org/10.1039/C6FO00039H

Data from epidemiological and in vitro studies suggest that orange juice (OJ) may have a positive impact on lipid metabolism. However, there have been reports in the media claiming detrimental consequences of 100% juice consumption, including weight-... Read More about Orange juice consumption and its effect on blood lipid profile and indices of the metabolic syndrome; a randomised, controlled trial in an at-risk population.

PlanHab: the combined and separate effects of 16 days of bed rest and normobaric hypoxic confinement on circulating lipids and indices of insulin sensitivity in healthy men (2016)
Journal Article
Simpson, E. J., Debevec, T., Eiken, O., Mekjavic, I., & Macdonald, I. (2016). PlanHab: the combined and separate effects of 16 days of bed rest and normobaric hypoxic confinement on circulating lipids and indices of insulin sensitivity in healthy men. Journal of Applied Physiology, 120(8), 947-955. doi:10.1152/japplphysiol.00897.2015

Separate and combined effects of 21-day bed rest and hypoxic confinement on body composition (2014)
Journal Article
Debevec, T., Bali, T. C., Simpson, E. J., Macdonald, I. A., Eiken, O., & Mekjavic, I. B. (2014). Separate and combined effects of 21-day bed rest and hypoxic confinement on body composition. European Journal of Applied Physiology, 114(11), 2411-2425. https://doi.org/10.1007/s00421-014-2963-1

Purpose: This study tested the hypothesis that hypoxia exacerbates reductions in body mass observed during unloading. Methods: To discern the separate and combined effects of simulated microgravity and hypoxia, 11 healthy males underwent three 21-... Read More about Separate and combined effects of 21-day bed rest and hypoxic confinement on body composition.

Effect of fructose and sucralose on flow-mediated vasodilatation in healthy, white European males (2014)
Journal Article
Memon, M. Q., Simpson, E. J., & Macdonald, I. A. (2014). Effect of fructose and sucralose on flow-mediated vasodilatation in healthy, white European males. Journal- Pakistan Medical Association, 64(7), 743-747

Objective: To assess how acute consumption of fructose affects flow-mediated dilatation in brachial artery. Methods: The randomised cross-over study was conducted at the University of Nottingham's Medical School, Nottingham, United Kingdom in July 20... Read More about Effect of fructose and sucralose on flow-mediated vasodilatation in healthy, white European males.

Investigation of the haemodynamic effects of exenatide in healthy male subjects (2012)
Journal Article
Mendis, B., Simpson, E., Macdonald, I., & Mansell, P. (2012). Investigation of the haemodynamic effects of exenatide in healthy male subjects. British Journal of Clinical Pharmacology, 74(3), 437-444. https://doi.org/10.1111/j.1365-2125.2012.04214.x

AIMS In clinical studies of glucagon-like peptide-1 (GLP-1) agonists used in the management of patients with type 2 diabetes, there is often a small accompanying fall in blood pressure. The mechanism underlying this effect is not known, although exen... Read More about Investigation of the haemodynamic effects of exenatide in healthy male subjects.

Fat oxidation during exercise and satiety during recovery are increased following a low-glycemic index breakfast in sedentary women (2009)
Journal Article
Stevenson, E. J., Astbury, N. M., Simpson, E. J., Taylor, M. A., & Macdonald, I. A. (2009). Fat oxidation during exercise and satiety during recovery are increased following a low-glycemic index breakfast in sedentary women. Journal of Nutrition, 139(5), 890-897. https://doi.org/10.3945/jn.108.101956

Consuming low-glycemic index (LGI) carbohydrates (CHO) before endurance exercise results in increased fat oxidation during exercise in trained men and women. It is not known if this phenomenon occurs during low intensity exercise and in untrained par... Read More about Fat oxidation during exercise and satiety during recovery are increased following a low-glycemic index breakfast in sedentary women.

Interstitial glucose profile associated with symptoms attributed to hypoglycemia by otherwise healthy women (2008)
Journal Article
Simpson, E. J., Holdsworth, M., & Macdonald, I. A. (2008). Interstitial glucose profile associated with symptoms attributed to hypoglycemia by otherwise healthy women. American Journal of Clinical Nutrition, 87(2), 354-361. https://doi.org/10.1093/ajcn/87.2.354

Background: Reports of postprandial symptoms attributed to hypoglycemia by otherwise healthy individuals appear to be relatively common in UK women. Whether these symptoms are related to blood glucose is a contentious issue, which periodic ambulatory... Read More about Interstitial glucose profile associated with symptoms attributed to hypoglycemia by otherwise healthy women.