All Outputs (3)

Disruption of the human papillomavirus type 16 E2 gene protects cervical carcinoma cells from E2F-induced apoptosis (1997)
Journal Article
Sanchez-Perez, A., Soriano, S., Clarke, A. R., & Gaston, K. (1997). Disruption of the human papillomavirus type 16 E2 gene protects cervical carcinoma cells from E2F-induced apoptosis. Journal of General Virology, 78(11), 3009-3018. https://doi.org/10.1099/0022-1317-78-11-3009

Human papillomavirus type 16 (HPV-16) is a DNA tumour virus that has been implicated in the development of cervical cancer. In non-transformed HPV-infected cells, the HPV E2 protein regulates transcription of the viral E6 and E7 oncogenes. Malignant... Read More about Disruption of the human papillomavirus type 16 E2 gene protects cervical carcinoma cells from E2F-induced apoptosis.

A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors (1997)
Journal Article
Cole, E. G., & Gaston, K. (1997). A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors. Nucleic Acids Research, 25(18), 3705-3711. https://doi.org/10.1093/nar/25.18.3705

The human Surf-1 and Surf-2 housekeeping genes are divergently transcribed and share a bi-directional, TATA-less promoter. Housekeeping promoters typically contain complex arrays of transcription factor binding sites and several studies have suggeste... Read More about A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors.

DNA binding and bending by the human papillomavirus type 16 E2 protein: recognition of an extended binding site (1997)
Journal Article
Thain, A., Webster, K., Emery, D., Clarke, A. R., & Gaston, K. (1997). DNA binding and bending by the human papillomavirus type 16 E2 protein: recognition of an extended binding site. Journal of Biological Chemistry, 272(13), 8236-8242. https://doi.org/10.1074/jbc.272.13.8236

The human papillomavirus (HPV) 16 E2 protein (hE2) binds to four sites present upstream of the P97 promoter and regulates transcription of the viral E6 and E7 oncogenes. We have determined the relative binding constants for the interaction of the ful... Read More about DNA binding and bending by the human papillomavirus type 16 E2 protein: recognition of an extended binding site.