A Model of Zymogen Factor XII: Insights into Protease Activation
(2025)
Journal Article
Shamanaev, A., Ma, Y., Ponczek, M. B., Sun, M.-F., Cheng, Q., Dickeson, S. K., McCarty, O. J., Emsley, J., Mohammed, B. M., & Gailani, D. (2025). A Model of Zymogen Factor XII: Insights into Protease Activation. Blood Advances, https://doi.org/10.1182/bloodadvances.2025015842
In plasma, the zymogens factor XII (FXII) and prekallikrein reciprocally convert each other to the proteases FXIIa and plasma kallikrein (PKa). PKa cleaves high-molecular-weight kininogen (HK) to release bradykinin, which contributes to regulation of... Read More about A Model of Zymogen Factor XII: Insights into Protease Activation.