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The C terminus of p73 is essential for hippocampal development (2020)
Journal Article
Morone, N., Amelio, I., Panatta, E., Niklison-Chirou, M. V., Steinert, J. R., Agostini, M., …Knight, R. A. (2020). The C terminus of p73 is essential for hippocampal development. Proceedings of the National Academy of Sciences, 117(27), 15694-15701. https://doi.org/10.1073/pnas.2000917117

The p53 family member p73 has a complex gene structure, including alternative promoters and alternative splicing of the 3′ UTR. This results in a complex range of isoforms whose biological relevance largely remains to be determined. By deleting exon... Read More about The C terminus of p73 is essential for hippocampal development.

Context is everything: extrinsic signalling and gain-of-function p53 mutants (2020)
Journal Article
Amelio, I., & Melino, G. (2020). Context is everything: extrinsic signalling and gain-of-function p53 mutants. Cell Death Discovery, 6, Article 16. https://doi.org/10.1038/s41420-020-0251-x

The TP53 genomic locus is a target of mutational events in at least half of cancers. Despite several decades of study, a full consensus on the relevance of the acquisition of p53 gain-of-function missense mutants has not been reached. Depending on ca... Read More about Context is everything: extrinsic signalling and gain-of-function p53 mutants.

Glutathione–Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair (2020)
Journal Article
Di Giovanni, E., Buonvino, S., Amelio, I., & Melino, S. (2020). Glutathione–Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair. International Journal of Molecular Sciences, 21(5), Article 1638. https://doi.org/10.3390/ijms21051638

The endogenous gasotransmitter H2S plays an important role in the central nervous, respiratory and cardiovascular systems. Accordingly, slow-releasing H2S donors are powerful tools for basic studies and innovative pharmaco-therapeutic agents for card... Read More about Glutathione–Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair.

p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms (2019)
Journal Article
Pitolli, C., Wang, Y., Candi, E., Shi, Y., Melino, G., & Amelio, I. (2019). p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms. Cancers, 11(12), https://doi.org/10.3390/cancers11121983

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. The tumor suppressor p53 regulates different cellular pathways involved in cell survival, DNA repair, apoptosis, and senescence. However, according to an increasing number of studies, the p53-... Read More about p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms.

Cell death pathologies: targeting death pathways and the immune system for cancer therapy (2018)
Journal Article
Pentimalli, F., Grelli, S., Di Daniele, N., Melino, G., & Amelio, I. (2019). Cell death pathologies: targeting death pathways and the immune system for cancer therapy. Genes and Immunity, 20(7), 539-554. https://doi.org/10.1038/s41435-018-0052-x

Alterations in the molecular mechanisms of cell death are a common feature of cancer. These alterations enable malignant cells to survive intrinsic death signalling leading to accumulation of genetic aberrations and helping them to cope with adverse... Read More about Cell death pathologies: targeting death pathways and the immune system for cancer therapy.

TAp73 regulates ATP7A: possible implications for ageing-related diseases (2018)
Journal Article
Lopriore, P., Capitanio, N., Panatta, E., Di Daniele, N., Gambacurta, A., Melino, G., & Amelio, I. (2018). TAp73 regulates ATP7A: possible implications for ageing-related diseases. Aging, 10(12), 3745-3760. https://doi.org/10.18632/aging.101669

The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system. Despite the extensive effort directed to define the molecul... Read More about TAp73 regulates ATP7A: possible implications for ageing-related diseases.

Sustained protein synthesis and reduced eEF2K levels in TAp73-\- mice brain: a possible compensatory mechanism (2018)
Journal Article
Willis, A. E., Rotblat, B., Agostini, M., Amelio, I., Niklison-Chirou, M. V., & Melino, G. (2018). Sustained protein synthesis and reduced eEF2K levels in TAp73-\- mice brain: a possible compensatory mechanism. Cell Cycle, 17(23), 2637-2643. https://doi.org/10.1080/15384101.2018.1553341

The transcription factor p73 is a member of the p53 family, of which the transactivation domain containing isoform (TAp73) plays key roles in brain development and neuronal stem cells. TAp73 also facilitates homoeostasis and prevents oxidative damage... Read More about Sustained protein synthesis and reduced eEF2K levels in TAp73-\- mice brain: a possible compensatory mechanism.

p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression (2018)
Journal Article
Amelio, I., Antonov, A. A., Mancini, M., Petrova, V., Cairns, R. A., Vikhreva, P., …Melino, G. (2018). p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression. Proceedings of the National Academy of Sciences, 115(46), E10869-E10878. https://doi.org/10.1073/pnas.1808314115

Mutations in the TP53 gene and microenvironmentally driven activation of hypoxia-inducible factor-1 (HIF-1) typically occur in later stages of tumorigenesis. An ongoing challenge is the identification of molecular determinants of advanced cancer path... Read More about p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression.

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine (2018)
Journal Article
Carbone, M., Amelio, I., Affar, E. B., Brugarolas, J., Cannon-Albright, L. A., Cantley, L. C., …Melino, G. (2018). Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine. Cell Death and Differentiation, 25(11), 1885-1904. https://doi.org/10.1038/s41418-018-0213-5

The relative contribution of intrinsic genetic factors and extrinsic environmental ones to cancer aetiology and natural history is a lengthy and debated issue. Gene–environment interactions (G x E) arise when the combined presence of both a germline... Read More about Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine.

Similar Domains for Different Regulations of p53 Family (2018)
Journal Article
Amelio, I., & Melino, G. (2018). Similar Domains for Different Regulations of p53 Family. Structure, 26(8), 1047-1049. https://doi.org/10.1016/j.str.2018.07.003

Despite the sequence similarity, the p53 family members are involved in different biological processes due to distinct expression patterns and transcriptional programs. In this issue of Structure, Krauskopf et al. (2018) reveal a different structural... Read More about Similar Domains for Different Regulations of p53 Family.

TAp73 contributes to the oxidative stress response by regulating protein synthesis (2018)
Journal Article
Marini, A., Rotblat, B., Sbarrato, T., Niklison-Chirou, M. V., Knight, J. R. P., Dudek, K., …Melino, G. (2018). TAp73 contributes to the oxidative stress response by regulating protein synthesis. Proceedings of the National Academy of Sciences, 115(24), 6219-6224. https://doi.org/10.1073/pnas.1718531115

TAp73 is a transcription factor that plays key roles in brain development, aging, and cancer. At the cellular level, TAp73 is a critical homeostasis-maintaining factor, particularly following oxidative stress. Although major studies focused on TAp73... Read More about TAp73 contributes to the oxidative stress response by regulating protein synthesis.

p73 Alternative Splicing: Exploring a Biological Role for the C-Terminal Isoforms (2018)
Journal Article
Vikhreva, P., Melino, G., & Amelio, I. (2018). p73 Alternative Splicing: Exploring a Biological Role for the C-Terminal Isoforms. Journal of Molecular Biology, 430(13), 1829-1838. https://doi.org/10.1016/j.jmb.2018.04.034

p73 (encoded by TP73 gene) is a p53 related protein that functions as a transcriptional factor. Similarly to p53, following DNA damage, p73 is stabilized and activated and controls expression of target genes that are involved in the regulation of cyc... Read More about p73 Alternative Splicing: Exploring a Biological Role for the C-Terminal Isoforms.

Integrin-?4 is a novel transcriptional target of TAp73 (2018)
Journal Article
Xie, N., Vikhreva, P., Annicchiarico-Petruzzelli, M., Amelio, I., Barlev, N., Knight, R. A., & Melino, G. (2018). Integrin-?4 is a novel transcriptional target of TAp73. Cell Cycle, 17(5), 589-594. https://doi.org/10.1080/15384101.2017.1403684

As a member of p53 family, p73 has attracted intense investigations due to its structural and functional similarities to p53. Among more than ten p73 variants, the transactivation (TA) domain-containing isoform TAp73 is the one that imitates the p53'... Read More about Integrin-?4 is a novel transcriptional target of TAp73.

The hypoxic tumour microenvironment (2018)
Journal Article
Petrova, V., Annicchiarico-Petruzzelli, M., Melino, G., & Amelio, I. (2018). The hypoxic tumour microenvironment. Oncogenesis, 7, Article 10. https://doi.org/10.1038/s41389-017-0011-9

Cancer progression often benefits from the selective conditions present in the tumour microenvironment, such as the presence of cancer-associated fibroblasts (CAFs), deregulated ECM deposition, expanded vascularisation and repression of the immune re... Read More about The hypoxic tumour microenvironment.

Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism (2017)
Journal Article
Nemajerova, A., Amelio, I., Gebel, J., Dötsch, V., Melino, G., & Moll, U. M. (2018). Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism. Cell Death and Differentiation, 25(1), 144-153. https://doi.org/10.1038/cdd.2017.178

The p53 family of transcription factors (p53, p63 and p73) covers a wide range of functions critical for development, homeostasis and health of mammals across their lifespan. Beside the well-established tumor suppressor role, recent evidence has high... Read More about Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism.