All Outputs (8)

Effects of implementation of a care bundle on rates of necrotising enterocolitis and own mother’s milk feeding in the East Midlands: protocol for a mixed methods impact and process evaluation study (2024)
Journal Article
Abramson, J., Szatkowski, L., Bains, M., Orton, E., Budge, H., Spruce, M., & Ojha, S. (2024). Effects of implementation of a care bundle on rates of necrotising enterocolitis and own mother’s milk feeding in the East Midlands: protocol for a mixed methods impact and process evaluation study. BMJ Open, 14(5), Article e078633. https://doi.org/10.1136/bmjopen-2023-078633

Introduction: Prevention of necrotising enterocolitis (NEC) is vital for improving neonatal outcomes. Feeding own mother’s milk helps prevent NEC. Rates of own mother’s milk feeding in the East Midlands are lower than the national average and the inc... Read More about Effects of implementation of a care bundle on rates of necrotising enterocolitis and own mother’s milk feeding in the East Midlands: protocol for a mixed methods impact and process evaluation study.

Association between opioid use during mechanical ventilation in preterm infants and evidence of brain injury: a propensity score-matched cohort study (2023)
Journal Article
Szatkowski, L., Sharkey, D., Budge, H., & Ojha, S. (2023). Association between opioid use during mechanical ventilation in preterm infants and evidence of brain injury: a propensity score-matched cohort study. eClinicalMedicine, 65, Article 102296. https://doi.org/10.1016/j.eclinm.2023.102296

Background: Preterm infants often require mechanical ventilation (MV), which can be a painful experience. Opioids (such as morphine) are used to provide analgesia, despite conflicting evidence about their impact on the developing brain. We aimed to q... Read More about Association between opioid use during mechanical ventilation in preterm infants and evidence of brain injury: a propensity score-matched cohort study.

Observational cohort study of use of caffeine in preterm infants and association between early caffeine use and neonatal outcomes (2023)
Journal Article
Szatkowski, L., Fateh, S., Abramson, J., Kwok, T. C., Sharkey, D., Budge, H., & Ojha, S. (2023). Observational cohort study of use of caffeine in preterm infants and association between early caffeine use and neonatal outcomes. Archives of Disease in Childhood. Fetal and Neonatal Edition, 108(5), 505-510. https://doi.org/10.1136/archdischild-2022-324919

Objective: To quantify trends in caffeine use in infants born at <32 weeks' gestational age (GA), and to investigate the effects of early vs late caffeine on neonatal outcomes. Study design: Retrospective propensity score matched cohort study using r...

Maternal nutrient restriction during early fetal kidney development attenuates the renal innate inflammatory response in obese young adult offspring (2009)
Journal Article
Sharkey, D., Gardner, D. S., Symonds, M. E., & Budge, H. (2009). Maternal nutrient restriction during early fetal kidney development attenuates the renal innate inflammatory response in obese young adult offspring. AJP - Renal Physiology, 297(5), F1199-F1207. https://doi.org/10.1152/ajprenal.00303.2009

Obesity is an independent risk factor for developing chronic kidney disease. Toll-like receptor 4 (TLR4), interleukin (IL)-18, and uncoupling protein 2 (UCP2) are important components of the innate immune system mediating inflammatory renal damage. E... Read More about Maternal nutrient restriction during early fetal kidney development attenuates the renal innate inflammatory response in obese young adult offspring.

Impact of early onset obesity and hypertension on the unfolded protein response in renal tissues of juvenile sheep (2009)
Journal Article
Sharkey, D., Fainberg, H. P., Wilson, V., Harvey, E., Gardner, D. S., Symonds, M. E., & Budge, H. (2009). Impact of early onset obesity and hypertension on the unfolded protein response in renal tissues of juvenile sheep. Hypertension, 53(6), 925-931. https://doi.org/10.1161/HYPERTENSIONAHA.108.122812

Childhood obesity has reached epidemic proportions. Obesity is an independent risk factor for the development of end-stage renal disease. Endoplasmic reticulum stress and subsequent activation of the unfolded protein response (UPR) are implicated in... Read More about Impact of early onset obesity and hypertension on the unfolded protein response in renal tissues of juvenile sheep.

Maternal nutrient restriction during pregnancy differentially alters the unfolded protein response in adipose and renal tissue of obese juvenile offspring (2008)
Journal Article
Sharkey, D., Gardner, D. S., Fainberg, H. P., Sébert, S., Bos, P., Wilson, V., Bell, R., Symonds, M. E., & Budge, H. (2009). Maternal nutrient restriction during pregnancy differentially alters the unfolded protein response in adipose and renal tissue of obese juvenile offspring. FASEB Journal, 23(5), 1314-1324. https://doi.org/10.1096/fj.08-114330

Maternal diet during pregnancy can program an offspring's risk of disease in later life. Obesity adversely alters renal and adipose tissue function, resulting in chronic kidney disease and insulin resistance, respectively, the latter associated with... Read More about Maternal nutrient restriction during pregnancy differentially alters the unfolded protein response in adipose and renal tissue of obese juvenile offspring.

Nutritional programming of foetal development: Endocrine mediators and long-term outcomes for cardiovascular health (2006)
Journal Article
Symonds, M. E., Budge, H., Mostyn, A., Stephenson, T., & Gardner, D. S. (2006). Nutritional programming of foetal development: Endocrine mediators and long-term outcomes for cardiovascular health. Current Nutrition and Food Science, 2(4), 389-398. https://doi.org/10.2174/157340106778699430

Epidemiological studies on historical and contemporary populations indicate that the uterine environment is a major factor contributing to later health and disease in the resulting offspring. These findings are supported by experimental studies which... Read More about Nutritional programming of foetal development: Endocrine mediators and long-term outcomes for cardiovascular health.

Maternal nutritional programming of fetal adipose tissue development: Long-term consequences for later obesity (2005)
Journal Article
Budge, H., Gnanalingham, M. G., Gardner, D. S., Mostyn, A., Stephenson, T., & Symonds, M. E. (2005). Maternal nutritional programming of fetal adipose tissue development: Long-term consequences for later obesity. Birth Defects Research Part C: Embryo Today: Reviews, 75(3), 193-199. https://doi.org/10.1002/bdrc.20044

As obesity reaches epidemic levels in the United States there is an urgent need to understand the developmental pathways leading to this condition. Obesity increases the risk of hypertension and diabetes, symptoms of which are being seen with increas... Read More about Maternal nutritional programming of fetal adipose tissue development: Long-term consequences for later obesity.