Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity
(2015)
Journal Article
Mussai, F., Egan, S. A., Hunter, S., Webber, H., Fisher, J., Wheat, R., …De Santo, C. (2015). Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity. Cancer Research, 75(15), https://doi.org/10.1158/0008-5472.CAN-14-3443
Neuroblastoma is the most common extra cranial solid tumour of childhood, and survival remains poor for patients with advanced disease. Novel immune therapies are currently in development, but clinical outcomes have not matched preclinical results. H... Read More about Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity.