Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts

Sharpe, Benjamin P.; Hayden, Annette; Manousopoulou, Antigoni; Cowie, Andrew; Walker, Robert C.; Harrington, Jack; Izadi, Fereshteh; Breininger, Stella P.; Gibson, Jane; Pickering, Oliver; Jaynes, Eleanor; Kyle, Ewan; Saunders, John H.; Parsons, Simon L.; Ritchie, Alison A.; Clarke, Philip A.; Collier, Pamela; Mongan, Nigel P.; Bates, David O.; Yacqub-Usman, Kiren; Garbis, Spiros D.; Walters, Zoë; Rose-Zerilli, Matthew; Grabowska, Anna M.; Underwood, Timothy J.

doi:10.1016/j.xcrm.2022.100541

All Outputs (3)

Looking Under the Lamppost: The Search for New Cancer Targets in the Human Kinome (2022)
Journal Article
Sueca-Comes, M., Rusu, E. C., Grabowska, A. M., & Bates, D. O. (2022). Looking Under the Lamppost: The Search for New Cancer Targets in the Human Kinome. Pharmacological Reviews, 74(4), 1136-1145. https://doi.org/10.1124/pharmrev.121.000410

The number of cancer drugs is increasing as new chemical entities are developed to target molecules, often protein kinases, driving cancer progression. In 2009, Fedorov et al. identified that of the protein kinases in the human kinome, most of the fo... Read More about Looking Under the Lamppost: The Search for New Cancer Targets in the Human Kinome.

Electronic prescribing systems in hospitals to improve medication safety: a multimethods research programme (2022)
Journal Article
Sheikh, A., Coleman, J., Chuter, A., Williams, R., Lilford, R., Slee, A., Morrison, Z., Cresswell, K., Robertson, A., Slight, S., Mozaffar, H., Lee, L., Shah, S., Pontefract, S., King, A., Wiegel, V., Watson, S., Salema, N.-E., Bates, D., Avery, A., …Watson, N. (2022). Electronic prescribing systems in hospitals to improve medication safety: a multimethods research programme. Programme Grants for Applied Research, 10(7), 1-164. https://doi.org/10.3310/KSRS2009

Background:
There is a need to identify approaches to reduce medication errors. Interest has converged on ePrescribing systems that incorporate computerised provider order entry and clinical decision support functionality.

Objectives:
We soug... Read More about Electronic prescribing systems in hospitals to improve medication safety: a multimethods research programme.

Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts (2022)
Journal Article
Sharpe, B. P., Hayden, A., Manousopoulou, A., Cowie, A., Walker, R. C., Harrington, J., Izadi, F., Breininger, S. P., Gibson, J., Pickering, O., Jaynes, E., Kyle, E., Saunders, J. H., Parsons, S. L., Ritchie, A. A., Clarke, P. A., Collier, P., Mongan, N. P., Bates, D. O., Yacqub-Usman, K., …Underwood, T. J. (2022). Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts. Cell Reports Medicine, 3(6), Article 100541. https://doi.org/10.1016/j.xcrm.2022.100541

The chemotherapy resistance of esophageal adenocarcinomas (EACs) is underpinned by cancer cell extrinsic mechanisms of the tumor microenvironment (TME). We demonstrate that, by targeting the tumor-promoting functions of the predominant TME cell type,... Read More about Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts.