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Tripartite Motif Containing 2, a glutamine metabolism-associated protein, predicts poor patient outcome in triple negative breast cancer treated with chemotherapy (2024)
Journal Article
Masisi, B. K., Ansari, R. E., Alfarsi, L., Fakroun, A., Erkan, B., Ibrahim, A., …Green, A. R. (in press). Tripartite Motif Containing 2, a glutamine metabolism-associated protein, predicts poor patient outcome in triple negative breast cancer treated with chemotherapy. Cancers,

Background Breast cancer (BC) remains heterogeneous in terms of prognosis and response to treatment. Metabolic reprogramming is a critical part of oncogenesis and a potential therapeutic target. Glutaminase (GLS), which generates glutamate from glu... Read More about Tripartite Motif Containing 2, a glutamine metabolism-associated protein, predicts poor patient outcome in triple negative breast cancer treated with chemotherapy.

Expression of Cathepsin D in early-stage breast cancer and its prognostic and predictive value (2024)
Journal Article
Alhudiri, I., Nolan, C., Ellis, I., Elzagheid, A., Green, A., & Chapman, C. (2024). Expression of Cathepsin D in early-stage breast cancer and its prognostic and predictive value. Breast Cancer Research and Treatment, https://doi.org/10.1007/s10549-024-07293-y

Purpose Cathepsin D is a proteolytic enzyme that is normally localized in the lysosomes and is involved in the malignant progression of breast cancer. There are conflicting results regarding Cathepsin D significance as prognostic and predictor marke... Read More about Expression of Cathepsin D in early-stage breast cancer and its prognostic and predictive value.