Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes

Johnson, Benjamin B; Cosson, Marie-Victoire; Tsansizi, Lorenza I; Holmes, Terri L; Gilmore, Tegan; Hampton, Katherine; Song, Ok-Ryul; Vo, Nguyen T N; Nasir, Aishah; Chabronova, Alzbeta; Denning, Chris; Peffers, Mandy J; Merry, Catherine L R; Whitelock, John; Troeberg, Linda; Rushworth, Stuart A; Bernardo, Andreia S; Smith, James G W

doi:10.1016/j.celrep.2023.113668

All Outputs (1)

Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes (2024)
Journal Article
Johnson, B. B., Cosson, M., Tsansizi, L. I., Holmes, T. L., Gilmore, T., Hampton, K., …Smith, J. G. W. (2024). Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes. Cell Reports, 43(1), Article 113668. https://doi.org/10.1016/j.celrep.2023.113668

Perlecan (HSPG2), a heparan sulfate proteoglycan similar to agrin, is key for extracellular matrix (ECM) maturation and stabilization. Although crucial for cardiac development, its role remains elusive. We show that perlecan expression increases as c... Read More about Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes.