Hidden dangers of antibiotic use: increased gut permeability mediated by increased pancreatic proteases reaching the colon

Spiller, Robin C.

Abstract

As we learn more about the importance of our microbiome in inflammatory, metabolic, and functional disorders, we are coming to appreciate the risks of disturbing this with broad-spectrum antibiotics. We have known for many years that as antibiotics have dramatically reduced the risk of infectious diseases, the incidence of other diseases such as inflammatory bowel disease, obesity, and type 2 diabetes mellitus have increased. Although the causes undoubtedly are multifactorial, meta-analysis showed that for Crohn’s disease (CD), antibiotic exposure nearly doubles the risk.

Citation

Spiller, R. C. (2018). Hidden dangers of antibiotic use: increased gut permeability mediated by increased pancreatic proteases reaching the colon. Cellular and Molecular Gastroenterology and Hepatology, 6(3), 347–348.e1. https://doi.org/10.1016/j.jcmgh.2018.06.005

• Journal Article Type: Article
• Acceptance Date: May 15, 2018
• Online Publication Date: Jul 11, 2018
• Publication Date: Aug 15, 2018
• Deposit Date: Jul 17, 2018
• Publicly Available Date: Jul 17, 2018
• Journal: Cellular and Molecular Gastroenterology and Hepatology
• Electronic ISSN: 2352-345X
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Issue: 3
• Pages: 347–348.e1
• DOI: https://doi.org/10.1016/j.jcmgh.2018.06.005
• Public URL: https://nottingham-repository.worktribe.com/output/946684
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S2352345X18300912
• Contract Date: Jul 17, 2018