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Hidden dangers of antibiotic use: increased gut permeability mediated by increased pancreatic proteases reaching the colon

Spiller, Robin C.

Authors

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ROBIN SPILLER ROBIN.SPILLER@NOTTINGHAM.AC.UK
Professor of Gastroenterology



Abstract

As we learn more about the importance of our microbiome in inflammatory, metabolic, and functional disorders, we are coming to appreciate the risks of disturbing this with broad-spectrum antibiotics. We have known for many years that as antibiotics have dramatically reduced the risk of infectious diseases, the incidence of other diseases such as inflammatory bowel disease, obesity, and type 2 diabetes mellitus have increased. Although the causes undoubtedly are multifactorial, meta-analysis showed that for Crohn’s disease (CD), antibiotic exposure nearly doubles the risk.

Citation

Spiller, R. C. (2018). Hidden dangers of antibiotic use: increased gut permeability mediated by increased pancreatic proteases reaching the colon. Cellular and Molecular Gastroenterology and Hepatology, 6(3), 347–348.e1. https://doi.org/10.1016/j.jcmgh.2018.06.005

Journal Article Type Article
Acceptance Date May 15, 2018
Online Publication Date Jul 11, 2018
Publication Date Aug 15, 2018
Deposit Date Jul 17, 2018
Publicly Available Date Jul 17, 2018
Journal Cellular and Molecular Gastroenterology and Hepatology
Electronic ISSN 2352-345X
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 6
Issue 3
Pages 347–348.e1
DOI https://doi.org/10.1016/j.jcmgh.2018.06.005
Public URL https://nottingham-repository.worktribe.com/output/946684
Publisher URL https://www.sciencedirect.com/science/article/pii/S2352345X18300912

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