NMR hyperpolarization techniques of gases

Barskiy, Danila A.; Coffey, Aaron M.; Nikolaou, Panayiotis; Mikhaylov, Dmitry M.; Goodson, Boyd M.; Branca, Rosa T.; Lu, George J.; Shapiro, Mikhail G.; Telkki, Ville-Veikko; Zhivonitko, Vladimir V.; Koptyug, Igor V.; Salnikov, Oleg G.; Kovtunov, Kirill V.; Bukhtiyarov, Valerii I.; Rosen, Matthew S.; Barlow, Michael J.; Safavi, Shahideh; Hall, Ian P.; Schr�der, Leif; Chekmenev, Eduard Y.

Abstract

Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4–8 orders of magnitude. Hyperpolarized gases, unlike liquids and solids, can often be readily separated and purified from the compounds used to mediate the hyperpolarization processes. These pure hyperpolarized gases enabled many novel MRI applications including the visualization of void spaces, imaging of lung function, and remote detection. Additionally, hyperpolarized gases can be dissolved in liquids and can be used as sensitive molecular probes and reporters. This Minireview covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.

Citation

Barskiy, D. A., Coffey, A. M., Nikolaou, P., Mikhaylov, D. M., Goodson, B. M., Branca, R. T., Lu, G. J., Shapiro, M. G., Telkki, V.-V., Zhivonitko, V. V., Koptyug, I. V., Salnikov, O. G., Kovtunov, K. V., Bukhtiyarov, V. I., Rosen, M. S., Barlow, M. J., Safavi, S., Hall, I. P., Schröder, L., & Chekmenev, E. Y. (2017). NMR hyperpolarization techniques of gases. Chemistry - A European Journal, 23(4), 725-751. https://doi.org/10.1002/chem.201603884

• Journal Article Type: Article
• Acceptance Date: Oct 6, 2016
• Online Publication Date: Dec 5, 2016
• Publication Date: Jan 20, 2017
• Deposit Date: Jul 21, 2017
• Publicly Available Date: Jul 21, 2017
• Journal: Chemistry - A European Journal
• Print ISSN: 0947-6539
• Electronic ISSN: 1521-3765
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 23
• Issue: 4
• Pages: 725-751
• DOI: https://doi.org/10.1002/chem.201603884
• Public URL: https://nottingham-repository.worktribe.com/output/839559
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1002/chem.201603884/abstract
• Additional Information: This is the peer reviewed version of the following article: D. A. Barskiy, A. M. Coffey, P. Nikolaou, D. M. Mikhaylov, B. M. Goodson, R. T. Branca, G. J. Lu, M. G. Shapiro, V.-V. Telkki, V. V. Zhivonitko, I. V. Koptyug, O. G. Salnikov, K. V. Kovtunov, V. I. Bukhtiyarov, M. S. Rosen, M. J. Barlow, S. Safavi, I. P. Hall, L. Schröder, E. Y. Chekmenev, Chem. Eur. J. 2017, 23, 725., which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/chem.201603884/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
• Contract Date: Jul 21, 2017