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NMR hyperpolarization techniques of gases

Barskiy, Danila A.; Coffey, Aaron M.; Nikolaou, Panayiotis; Mikhaylov, Dmitry M.; Goodson, Boyd M.; Branca, Rosa T.; Lu, George J.; Shapiro, Mikhail G.; Telkki, Ville-Veikko; Zhivonitko, Vladimir V.; Koptyug, Igor V.; Salnikov, Oleg G.; Kovtunov, Kirill V.; Bukhtiyarov, Valerii I.; Rosen, Matthew S.; Barlow, Michael J.; Safavi, Shahideh; Hall, Ian P.; Schröder, Leif; Chekmenev, Eduard Y.


Danila A. Barskiy

Aaron M. Coffey

Panayiotis Nikolaou

Dmitry M. Mikhaylov

Boyd M. Goodson

Rosa T. Branca

George J. Lu

Mikhail G. Shapiro

Ville-Veikko Telkki

Vladimir V. Zhivonitko

Igor V. Koptyug

Oleg G. Salnikov

Kirill V. Kovtunov

Valerii I. Bukhtiyarov

Matthew S. Rosen

Michael J. Barlow

Shahideh Safavi

Professor of Molecular Medicine

Leif Schröder

Eduard Y. Chekmenev


Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4–8 orders of magnitude. Hyperpolarized gases, unlike liquids and solids, can often be readily separated and purified from the compounds used to mediate the hyperpolarization processes. These pure hyperpolarized gases enabled many novel MRI applications including the visualization of void spaces, imaging of lung function, and remote detection. Additionally, hyperpolarized gases can be dissolved in liquids and can be used as sensitive molecular probes and reporters. This Minireview covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.


Barskiy, D. A., Coffey, A. M., Nikolaou, P., Mikhaylov, D. M., Goodson, B. M., Branca, R. T., …Chekmenev, E. Y. (2017). NMR hyperpolarization techniques of gases. Chemistry - A European Journal, 23(4), 725-751.

Journal Article Type Article
Acceptance Date Oct 6, 2016
Online Publication Date Dec 5, 2016
Publication Date Jan 20, 2017
Deposit Date Jul 21, 2017
Publicly Available Date Jul 21, 2017
Journal Chemistry - a European Journal
Print ISSN 0947-6539
Electronic ISSN 0947-6539
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 23
Issue 4
Pages 725-751
Public URL
Publisher URL
Copyright Statement Copyright information regarding this work can be found at the following address:
Additional Information This is the peer reviewed version of the following article: D. A. Barskiy, A. M. Coffey, P. Nikolaou, D. M. Mikhaylov, B. M. Goodson, R. T. Branca, G. J. Lu, M. G. Shapiro, V.-V. Telkki, V. V. Zhivonitko, I. V. Koptyug, O. G. Salnikov, K. V. Kovtunov, V. I. Bukhtiyarov, M. S. Rosen, M. J. Barlow, S. Safavi, I. P. Hall, L. Schröder, E. Y. Chekmenev, Chem. Eur. J. 2017, 23, 725., which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.


chem201603884.pdf (3.3 Mb)

Copyright Statement
Copyright information regarding this work can be found at the following address:

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