Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator

Marlow, Maria; Al-Ameedee, Mohammed; Smith, Thomas; Wheeler, Simon; Stocks, Michael J.

Abstract

In this study we demonstrate that linifanib, a multi-targeted receptor tyrosine kinase inhibitor, with a key urea containing pharmacophore, self-assembles into a hydrogel in the presence of low amounts of solvent. We demonstrate the role of the urea functional group and that of fluorine substitution on the adjacent aromatic ring in promoting self-assembly. We have also shown that linifanib has superior mechanical strength to two structurally related analogues and hence increased potential for localisation at an injection site for drug delivery applications.

Citation

Marlow, M., Al-Ameedee, M., Smith, T., Wheeler, S., & Stocks, M. J. (in press). Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator. Chemical Communications, 51, https://doi.org/10.1039/c5cc00454c

• Journal Article Type: Article
• Acceptance Date: Feb 26, 2015
• Online Publication Date: Feb 27, 2015
• Deposit Date: Nov 21, 2017
• Publicly Available Date: Nov 21, 2017
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 51
• DOI: https://doi.org/10.1039/c5cc00454c
• Public URL: https://nottingham-repository.worktribe.com/output/744321
• Publisher URL: http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC00454C#!divAbstract
• Contract Date: Nov 21, 2017