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Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept

Vedhara, Kavita; Ayling, Kieran; Jia, Ru; Fairclough, Lucy; Morling, Joanne R.; Ball, Jonathan K.; Knight, Holly; Blake, Holly; Corner, Jessica; Denning, Chris; Bolton, Kirsty; Jackson, Hannah; Coupland, Carol; Tighe, Patrick

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Authors

Kavita Vedhara

Ru Jia

JOANNE MORLING JOANNE.MORLING@NOTTINGHAM.AC.UK
Professor of Public Health and Epidemiology

Jonathan K. Ball

HOLLY KNIGHT HOLLY.KNIGHT@NOTTINGHAM.AC.UK
Senior Research Fellow

Profile image of HOLLY BLAKE

HOLLY BLAKE holly.blake@nottingham.ac.uk
Professor of Behavioural Medicine

Jessica Corner

CHRIS DENNING chris.denning@nottingham.ac.uk
Professor of Stem Cell Biology

Hannah Jackson

CAROL COUPLAND carol.coupland@nottingham.ac.uk
Professor of Medical Statistics

PATRICK TIGHE paddy.tighe@nottingham.ac.uk
Professor of Molecular Immunology



Abstract

Background: Psychological factors can influence susceptibility to viral infections. We examined whether such influences are evident in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Participants (n=102) completed measures of anxiety, depression, positive mood, and loneliness and provided a blood sample for the measurement of antibodies to the SARS-CoV-2 spike and nucleocapsid proteins. Results: SARS-CoV-2 was significantly negatively associated with anxiety and depression. The model remained significant after adjustment for age and gender, although anxiety and depression were no longer significant independent predictors. Conclusions: These findings offer early support for the hypothesis that psychological factors may influence susceptibility to SARS-CoV-2 infection.

Citation

Vedhara, K., Ayling, K., Jia, R., Fairclough, L., Morling, J. R., Ball, J. K., …Tighe, P. (2022). Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept. Journal of Infectious Diseases, 225(12), 2137-2141. https://doi.org/10.1093/infdis/jiac006

Journal Article Type Article
Acceptance Date Jan 7, 2022
Online Publication Date Jan 12, 2022
Publication Date Jun 15, 2022
Deposit Date Mar 1, 2022
Publicly Available Date Jan 13, 2023
Journal The Journal of Infectious Diseases
Print ISSN 0022-1899
Electronic ISSN 1537-6613
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 225
Issue 12
Pages 2137-2141
DOI https://doi.org/10.1093/infdis/jiac006
Keywords Infectious Diseases; Immunology and Allergy
Public URL https://nottingham-repository.worktribe.com/output/7351030
Publisher URL https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiac006/6504010

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