Mitochondria donation by mesenchymal stem cells: current understanding and mitochondria transplantation strategies

Gomzikova, Marina; James, Victoria; Rizvanov, Albert

doi:10.3389/fcell.2021.653322

Mitochondria donation by mesenchymal stem cells: current understanding and mitochondria transplantation strategies

Gomzikova, Marina; James, Victoria; Rizvanov, Albert

Authors

Marina Gomzikova

Professor VICTORIA JAMES VICTORIA.JAMES@NOTTINGHAM.AC.UK
PROFESSOR OF MOLECULAR BIOLOGY

Albert Rizvanov

Abstract

The phenomenon of mitochondria donation is found in various tissues of humans and animals and is attracting increasing attention. To date, numerous studies have described the transfer of mitochondria from stem cells to injured cells, leading to increased ATP production, restoration of mitochondria function and rescue of recipient cells from apoptosis. Mitochondria transplantation is considered as a novel therapeutic approach for the treatment of mitochondrial diseases and mitochondrial function deficiency. Mitochondrial dysfunction affects cells with high energy needs such as neural, skeletal muscles, heart and liver cells, and plays a crucial role in type 2 diabetes, as well as Parkinson's, Alzheimer's diseases, ischemia, stroke, cancer and age-related disorders. In this review, we summarize recent findings in the field of mitochondria donation and mechanism of mitochondria transfer between cells. We review the existing clinical trials and discuss advantages and disadvantages of mitochondrial transplantation strategies based on the injection of stem cells, isolated functional mitochondria or EVs containing mitochondria.

Citation

Gomzikova, M., James, V., & Rizvanov, A. (2021). Mitochondria donation by mesenchymal stem cells: current understanding and mitochondria transplantation strategies. Frontiers in Cell and Developmental Biology, 9, Article 653322. https://doi.org/10.3389/fcell.2021.653322

Journal Article Type	Article
Acceptance Date	Mar 9, 2021
Online Publication Date	Apr 7, 2021
Publication Date	Apr 7, 2021
Deposit Date	Mar 12, 2021
Publicly Available Date	Apr 7, 2021
Journal	Frontiers in Cell and Developmental Biology
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	9
Article Number	653322
DOI	https://doi.org/10.3389/fcell.2021.653322
Keywords	Mitochondria donation, Mitochondria transplantation, Tunneling nanotubes, Extracellular vesicles, Cell fusion, Isolated mitochondria.
Public URL	https://nottingham-repository.worktribe.com/output/5388206
Publisher URL	https://www.frontiersin.org/articles/10.3389/fcell.2021.653322/abstract
Additional Information	First publication by Frontiers Media