Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young rats

Mallinson, Joanne E.; Sculley, Dean V.; Craigon, Jim; Plant, Richard; Langley-Evans, Simon C.; Brameld, John M.

Abstract

This study assessed the impact of reduced dietary protein during specific periods of fetal life upon muscle fibre development in young rats. Pregnant rats were fed a control or low-protein (LP) diet at early (days 0-7 gestation, LPEarly), mid (days 8-14, LPMid), late (days 15-22, LPLate) or throughout gestation (days 0-22, LPAll). The muscle fibre number and composition in soleus and gastrocnemius muscles of the offspring were studied at 4 weeks of age. In the soleus muscle, both the total number and density of fast fibres were reduced in LPMid females (P=004 for both, Diet × Sex × Fibre type interactions), while both the total number and density of glycolytic (non-oxidative) fibres were reduced in LPEarly, LPMid and LPLate (but not LPAll) offspring compared with controls (P

Citation

Mallinson, J. E., Sculley, D. V., Craigon, J., Plant, R., Langley-Evans, S. C., & Brameld, J. M. (2007). Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young rats. British Journal of Nutrition, 98(2), 292-299. https://doi.org/10.1017/S0007114507701678

• Journal Article Type: Article
• Acceptance Date: Jan 29, 2006
• Publication Date: Aug 1, 2007
• Deposit Date: Feb 9, 2021
• Journal: British Journal of Nutrition
• Print ISSN: 0007-1145
• Electronic ISSN: 1475-2662
• Publisher: Cambridge University Press
• Peer Reviewed: Peer Reviewed
• Volume: 98
• Issue: 2
• Pages: 292-299
• DOI: https://doi.org/10.1017/S0007114507701678
• Public URL: https://nottingham-repository.worktribe.com/output/3185883
• Publisher URL: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/fetal-exposure-to-a-maternal-lowprotein-diet-during-midgestation-results-in-musclespecific-effects-on-fibre-type-composition-in-young-rats/2C0284EB58E89D2BFC481A3E59F9EF10