Chronic effects of high-intensity interval training on postprandial lipemia in healthy men

Wilhelmsen, Andrew John; Tsintzas, Kostas; Mallinson, Joanne; Jones, Robert; Cooper, Scott; Taylor, Tariq

Abstract

The aim of this study was to determine thechronic (≥72h post-exercise) effects of high intensity interval training (HIIT) on postprandial lipaemia and metabolic markers in healthy volunteers. Eight physically active young males (Mean ± SD: age 22 ± 3years, height 1.77 ± 0.07m, body mass 67.7 ± 6.2kg) underwent two 6h mixed-meal tolerance tests and resting vastus lateralis muscle biopsies, before the first- and ≥72h after the final-session of four weeks of HIIT (16 sessions in total; 10x60s bouts of cycling at 90% maximal oxygen uptake [V̇O2max], interspersed by 60s intervals at 45% V̇O2max). Arterialised and deep venous blood samples across the forearm, brachial artery blood flow measurements, and whole-body indirect calorimetry data were obtained before, and at regular intervals for 6h after, consumption of a standardised mixed-meal. The main findings revealed that, when assessed ≥72h post-exercise, postprandial free fatty acid (FFA) uptake across the forearm was increased in response to exercise training (P= 0.025). However, four weeks of HIIT did not alter fasting or postprandial circulating triglyceride (TAG) concentrations, or their tissue uptake, despite a 10.2 ± 7.7% improvement in V̇O2max(P= 0.004). Protein content of adipose triglyceride lipase (ATGL) in the vastus lateralis at rest was reduced by 25 ± 21% (P= 0.01). Collectively, these findings suggest that 4 weeks of HITT enhances postprandial clearance of FFA, when assessed ≥72h post-exercise, but does not confer persisting (training) adaptations in postprandial triglyceridaemia.

Citation

Wilhelmsen, A. J., Tsintzas, K., Mallinson, J., Jones, R., Cooper, S., & Taylor, T. (2019). Chronic effects of high-intensity interval training on postprandial lipemia in healthy men. Journal of Applied Physiology, 127(6), 1763-1771. https://doi.org/10.1152/japplphysiol.00131.2019

• Journal Article Type: Article
• Acceptance Date: Oct 12, 2019
• Online Publication Date: Oct 17, 2019
• Publication Date: Dec 1, 2019
• Deposit Date: Nov 19, 2019
• Publicly Available Date: Oct 18, 2020
• Journal: Journal of Applied Physiology
• Print ISSN: 8750-7587
• Electronic ISSN: 1522-1601
• Publisher: American Physiological Society
• Peer Reviewed: Peer Reviewed
• Volume: 127
• Issue: 6
• Pages: 1763-1771
• DOI: https://doi.org/10.1152/japplphysiol.00131.2019
• Keywords: Physiology (medical); Physiology
• Public URL: https://nottingham-repository.worktribe.com/output/3331566
• Publisher URL: https://www.physiology.org/doi/abs/10.1152/japplphysiol.00131.2019
• Contract Date: Nov 19, 2019