Development of human electrophysiological brain networks

Briley, Paul M.; Liddle, Elizabeth B.; Groom, Madeleine J.; Smith, Helen J. F.; Morris, Peter G.; Colclough, Giles L.; Brookes, Matthew J.; Liddle, Peter F.

Abstract

Functional activity in the human brain is intrinsically organized into independently active, connected brain regions. These networks include sensorimotor systems, as well as higher-order cognitive networks such as the default mode network (DMN), which dominates activity when the brain is at rest, and the frontoparietal (FPN) and salience (SN) networks, which are often engaged during demanding tasks. Evidence from functional magnetic resonance imaging (fMRI) suggests that although sensory systems are mature by the end of childhood, the integrity of the FPN and SN develops throughout adolescence. There has been little work to corroborate these findings with electrophysiology. Using magnetoencephalography (MEG) recordings of 48 participants (aged 9–25 yr) at rest, we find that beta-band functional connectivity within the FPN, SN, and DMN continues to increase through adolescence, whereas connectivity in the visual system is mature by late childhood. In contrast to fMRI results, but replicating the MEG findings of Schäfer et al. (Schäfer CB, Morgan BR, Ye AX, Taylor MJ, Doesburg SM. Hum Brain Mapp 35: 5249–5261, 2014), we also see that connectivity between networks increases rather than decreases with age. This suggests that the development of coordinated beta-band oscillations within and between higher-order cognitive networks through adolescence might contribute to the developing abilities of adolescents to focus their attention and coordinate diverse aspects of mental activity.

Citation

Briley, P. M., Liddle, E. B., Groom, M. J., Smith, H. J. F., Morris, P. G., Colclough, G. L., …Liddle, P. F. (2018). Development of human electrophysiological brain networks. Journal of Neurophysiology, 120(6), 3122-3130. https://doi.org/10.1152/jn.00293.2018

• Journal Article Type: Article
• Acceptance Date: Oct 19, 2018
• Online Publication Date: Dec 7, 2018
• Publication Date: Dec 1, 2018
• Deposit Date: Apr 4, 2019
• Publicly Available Date: Apr 5, 2019
• Journal: Journal of Neurophysiology
• Print ISSN: 0022-3077
• Electronic ISSN: 1522-1598
• Publisher: American Physiological Society
• Peer Reviewed: Peer Reviewed
• Volume: 120
• Issue: 6
• Pages: 3122-3130
• DOI: https://doi.org/10.1152/jn.00293.2018
• Public URL: https://nottingham-repository.worktribe.com/output/1739134
• Publisher URL: https://www.physiology.org/doi/full/10.1152/jn.00293.2018
• Contract Date: Apr 4, 2019